{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T20:56:30Z","timestamp":1789419390422,"version":"build-2803163510"},"reference-count":35,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2020,3,5]],"date-time":"2020-03-05T00:00:00Z","timestamp":1583366400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2020,3,5]],"date-time":"2020-03-05T00:00:00Z","timestamp":1583366400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Acute pancreatitis (AP) is a common adverse event (AE) of endoscopic papillectomy (EP). Prophylactic plastic pancreatic stent (PPS) placement appears to prevent AP. We evaluated factors associated with post-EP AP by a retrospective analysis of patients with tumors of the duodenal papilla who underwent EP from January 2008 to November 2016 at 2 tertiary care centers. Clinical, laboratory, endoscopic ultrasound parameters, and PPS placement were evaluated. Seventy-two patients underwent EP (37 men), with mean age of 60.3 (31\u201388) years. Mean main pancreatic duct (MPD) diameter was 0.44 (0.18\u20131.8) cm. Mean tumor size was 1.8 (0.5\u20139.6) cm. Tumors were staged as uT1N0, uT2N0, and uT1N1 in 87.5%, 11.1%, and 1.4%. Thirty-eight AEs occurred in 33 (45.8%) patients, with no mortality. Total bilirubin, tumor size, MPD diameter, and PPS placement had odds ratios (ORs) of 0.82, 0.14, 0.00, and 6.43 for AP. Multivariate analysis (PPS placement\u2009\u00d7\u2009MPD diameter) showed ORs of 4.62 (95%CI, 1.03\u201321.32; <jats:italic>p<\/jats:italic>\u2009=\u20090.049) and 0.000 (95%CI, 0.00\u20130.74; <jats:italic>p<\/jats:italic>\u2009=\u20090.042) for AP. In conclusion, patients with jaundice, large tumors, and dilated MPD seem less likely to have post-EP AP. PPS placement was associated with a higher risk of AP, which may question its use.<\/jats:p>","DOI":"10.1038\/s41598-020-60941-3","type":"journal-article","created":{"date-parts":[[2020,3,5]],"date-time":"2020-03-05T11:06:26Z","timestamp":1583406386000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Analysis of risk factors associated with acute pancreatitis after endoscopic papillectomy"],"prefix":"10.1038","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1039-793X","authenticated-orcid":false,"given":"Eloy","family":"Taglieri","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ot\u00e1vio","family":"Micelli-Neto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eduardo Aimor\u00e9","family":"Bonin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suzan Menasce","family":"Goldman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rafael","family":"Kemp","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 Sebasti\u00e3o","family":"dos Santos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 Celso","family":"Ardengh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2020,3,5]]},"reference":[{"key":"60941_CR1","first-page":"1534","volume":"142","author":"A Scarpa","year":"1993","unstructured":"Scarpa, A. et al. Pancreatic adenocarcinomas frequently show p53 gene mutations. Am. J. Pathol. 142, 1534\u20131543 (1993).","journal-title":"Am. J. Pathol."},{"key":"60941_CR2","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1016\/S0016-5107(93)70051-6","volume":"39","author":"KF Binmoeller","year":"1993","unstructured":"Binmoeller, K. F., Boaventura, S., Ramsperger, K. & Soehendra, N. Endoscopic snare excision of benign adenomas of the papilla of Vater. Gastrointest. Endosc. 39, 127\u2013131 (1993).","journal-title":"Gastrointest. Endosc."},{"key":"60941_CR3","doi-asserted-by":"publisher","first-page":"239","DOI":"10.1016\/S0016-5107(02)70184-3","volume":"56","author":"ID Norton","year":"2002","unstructured":"Norton, I. D. et al. Safety and outcome of endoscopic snare excision of the major duodenal papilla. Gastrointest. Endosc. 56, 239\u2013243 (2002).","journal-title":"Gastrointest. Endosc."},{"key":"60941_CR4","doi-asserted-by":"publisher","first-page":"460","DOI":"10.1097\/00001574-200409000-00008","volume":"20","author":"RF Wong","year":"2004","unstructured":"Wong, R. F. & DiSario, J. A. Approaches to endoscopic ampullectomy. Curr. Opin. Gastroenterol. 20, 460\u2013467 (2004).","journal-title":"Curr. Opin. Gastroenterol."},{"key":"60941_CR5","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1097\/MCG.0b013e318233a844","volume":"46","author":"R Patel","year":"2012","unstructured":"Patel, R., Varadarajulu, S. & Wilcox, C. M. Endoscopic ampullectomy: techniques and outcomes. J. Clin. Gastroenterol. 46, 8\u201315 (2012).","journal-title":"J. Clin. Gastroenterol."},{"key":"60941_CR6","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1007\/s00464-009-0538-8","volume":"24","author":"T Yamao","year":"2010","unstructured":"Yamao, T. et al. Endoscopic snare papillectomy with biliary and pancreatic stent placement for tumors of the major duodenal papilla. Surg. Endosc. 24, 119\u2013124 (2010).","journal-title":"Surg. Endosc."},{"key":"60941_CR7","doi-asserted-by":"publisher","first-page":"773","DOI":"10.1016\/j.gie.2015.06.027","volume":"82","author":"KV Chathadi","year":"2015","unstructured":"Chathadi, K. V. et al. The role of endoscopy in ampullary and duodenal adenomas. Gastrointest. Endosc. 82, 773\u2013781 (2015).","journal-title":"Gastrointest. Endosc."},{"key":"60941_CR8","doi-asserted-by":"publisher","first-page":"367","DOI":"10.1016\/j.gie.2005.04.020","volume":"62","author":"GC Harewood","year":"2005","unstructured":"Harewood, G. C., Pochron, N. L. & Gostout, C. J. Prospective, randomized, controlled trial of prophylactic pancreatic stent placement for endoscopic snare excision of the duodenal ampulla. Gastrointest. Endosc. 62, 367\u2013370 (2005).","journal-title":"Gastrointest. Endosc."},{"key":"60941_CR9","doi-asserted-by":"publisher","first-page":"987","DOI":"10.4253\/wjge.v7.i10.987","volume":"7","author":"JC Ardengh","year":"2015","unstructured":"Ardengh, J. C., Kemp, R., Lima-Filho, E. R. & Dos Santos, J. S. Endoscopic papillectomy: the limits of the indication, technique and results. World J. Gastrointest. Endosc. 7, 987\u2013994 (2015).","journal-title":"World J. Gastrointest. Endosc."},{"key":"60941_CR10","doi-asserted-by":"publisher","first-page":"180","DOI":"10.1016\/j.ijsu.2014.11.045","volume":"13","author":"GD De Palma","year":"2015","unstructured":"De Palma, G. D. et al. Endoscopic snare papillectomy: a single institutional experience of a standardized technique. A retrospective cohort study. Int. J. Surg. 13, 180\u2013183 (2015).","journal-title":"Int. J. Surg."},{"key":"60941_CR11","doi-asserted-by":"publisher","first-page":"306","DOI":"10.5009\/gnl.2014.8.3.306","volume":"8","author":"WI Chang","year":"2014","unstructured":"Chang, W. I. et al. Prophylactic pancreatic stent placement for endoscopic duodenal ampullectomy: a single-center retrospective study. Gut. Liver. 8, 306\u2013312 (2014).","journal-title":"Gut. Liver."},{"key":"60941_CR12","doi-asserted-by":"publisher","first-page":"1014","DOI":"10.3109\/00365521.2011.571711","volume":"46","author":"O Jeanniard-Malet","year":"2011","unstructured":"Jeanniard-Malet, O. et al. Short-term results of 42 endoscopic ampullectomies: a single-center experience. Scand. J. Gastroenterol. 46, 1014\u20131019 (2011).","journal-title":"Scand. J. Gastroenterol."},{"key":"60941_CR13","doi-asserted-by":"publisher","first-page":"617","DOI":"10.1111\/den.12234","volume":"26","author":"G Trikudanathan","year":"2014","unstructured":"Trikudanathan, G., Njei, B., Attam, R., Arain, M. & Shaukat, A. Staging accuracy of ampullary tumors by endoscopic ultrasound: meta-analysis and systematic review. Dig. Endosc. 26, 617\u2013626 (2014).","journal-title":"Dig. Endosc."},{"key":"60941_CR14","doi-asserted-by":"publisher","first-page":"380","DOI":"10.1016\/j.gie.2014.08.005","volume":"81","author":"W Ridtitid","year":"2015","unstructured":"Ridtitid, W. et al. Performance characteristics of EUS for locoregional evaluation of ampullary lesions. Gastrointest. Endosc. 81, 380\u2013388 (2015).","journal-title":"Gastrointest. Endosc."},{"key":"60941_CR15","doi-asserted-by":"publisher","first-page":"389","DOI":"10.1016\/j.gie.2014.11.029","volume":"81","author":"J Gaspar","year":"2015","unstructured":"Gaspar, J. & Shami, V. M. The role of EUS in ampullary lesions: is the answer black and white? Gastrointest. Endosc. 81, 389\u2013390 (2015).","journal-title":"Gastrointest. Endosc."},{"key":"60941_CR16","doi-asserted-by":"publisher","first-page":"198","DOI":"10.4103\/2303-9027.162997","volume":"4","author":"M Sharma","year":"2015","unstructured":"Sharma, M., Rai, P., Rameshbabu, C. S. & Arya, S. Imaging of the pancreatic duct by linear endoscopic ultrasound. Endosc. Ultrasound. 4, 198\u2013207 (2015).","journal-title":"Endosc. Ultrasound."},{"key":"60941_CR17","doi-asserted-by":"publisher","first-page":"243","DOI":"10.1111\/j.1440-1746.2003.03142.x","volume":"19","author":"TE Yusuf","year":"2004","unstructured":"Yusuf, T. E. & Bhutani, M. S. Role of endoscopic ultrasonography in diseases of the extrahepatic biliary system. J. Gastroenterol. Hepatol. 19, 243\u2013250 (2004).","journal-title":"J. Gastroenterol. Hepatol."},{"key":"60941_CR18","doi-asserted-by":"publisher","first-page":"514","DOI":"10.1016\/S0016-5107(94)70228-4","volume":"40","author":"PB Cotton","year":"1994","unstructured":"Cotton, P. B. Outcomes of endoscopy procedures: struggling towards definitions. Gastrointest. Endosc. 40, 514\u2013518 (1994).","journal-title":"Gastrointest. Endosc."},{"key":"60941_CR19","doi-asserted-by":"publisher","first-page":"102","DOI":"10.1136\/gutjnl-2012-302779","volume":"62","author":"PA Banks","year":"2013","unstructured":"Banks, P. A. et al. Classification of acute pancreatitis \u2013 2012: revision of the Atlanta classification and definitions by international consensus. Gut. 62, 102\u2013111 (2013).","journal-title":"Gut."},{"key":"60941_CR20","doi-asserted-by":"publisher","first-page":"551","DOI":"10.1016\/j.gie.2005.04.053","volume":"62","author":"S Bohnacker","year":"2005","unstructured":"Bohnacker, S. et al. Endoscopic resection of benign tumors of the duodenal papilla without and with intraductal growth. Gastrointest. Endosc. 62, 551\u2013560 (2005).","journal-title":"Gastrointest. Endosc."},{"key":"60941_CR21","doi-asserted-by":"publisher","first-page":"292","DOI":"10.1016\/j.gie.2005.07.022","volume":"63","author":"J Han","year":"2006","unstructured":"Han, J. & Kim, M. H. Endoscopic papillectomy for adenomas of the major duodenal papilla (with video). Gastrointest. Endosc. 63, 292\u2013301 (2006).","journal-title":"Gastrointest. Endosc."},{"key":"60941_CR22","doi-asserted-by":"publisher","first-page":"23","DOI":"10.4161\/jig.20131","volume":"2","author":"M Bassan","year":"2012","unstructured":"Bassan, M. & Bourke, M. Endoscopic ampullectomy: a practical guide. J. Interv. Gastroenterol. 2, 23\u201330 (2012).","journal-title":"J. Interv. Gastroenterol."},{"key":"60941_CR23","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1159\/000286607","volume":"27","author":"K Ito","year":"2010","unstructured":"Ito, K., Fujita, N., Noda, Y., Kobayashi, G. & Horaguchi, J. Diagnosis of ampullary cancer. Dig. Surg. 27, 115\u2013118 (2010).","journal-title":"Dig. Surg."},{"key":"60941_CR24","doi-asserted-by":"publisher","first-page":"521","DOI":"10.1055\/s-2006-925263","volume":"38","author":"S Bohnacker","year":"2006","unstructured":"Bohnacker, S., Soehendra, N., Maguchi, H., Chung, J. B. & Howell, D. A. Endoscopic resection of benign tumors of the papilla of Vater. Endoscopy. 38, 521\u2013525 (2006).","journal-title":"Endoscopy."},{"key":"60941_CR25","doi-asserted-by":"publisher","first-page":"347","DOI":"10.1016\/j.giec.2013.01.003","volume":"23","author":"HK Kim","year":"2013","unstructured":"Kim, H. K. & Lo, S. K. Endoscopic approach to the patient with benign or malignant ampullary lesions. Gastrointest. Endosc. Clin. N. Am. 23, 347\u2013383 (2013).","journal-title":"Gastrointest. Endosc. Clin. N. Am."},{"key":"60941_CR26","doi-asserted-by":"publisher","first-page":"3865","DOI":"10.1007\/s00464-013-2996-2","volume":"27","author":"W Laleman","year":"2013","unstructured":"Laleman, W. et al. Endoscopic resection of ampullary lesions: a single-center 8-year retrospective cohort study of 91 patients with long-term follow-up. Surg. Endosc. 27, 3865\u20133876 (2013).","journal-title":"Surg. Endosc."},{"key":"60941_CR27","doi-asserted-by":"publisher","first-page":"2349","DOI":"10.1007\/s00464-014-3467-0","volume":"28","author":"T Ma","year":"2014","unstructured":"Ma, T. et al. Recurrences are common after endoscopic ampullectomy for adenoma in the familial adenomatous polyposis (FAP) syndrome. Surg. Endosc. 28, 2349\u20132356 (2014).","journal-title":"Surg. Endosc."},{"key":"60941_CR28","doi-asserted-by":"crossref","unstructured":"Ardengh, J. C., Lemos de Bonotto, M., Surjan, R., Pereira Lima, J. & Machado, M.A. Unprecedented case of duodenal papillary disinsertion after endoscopic papillectomy for a neuroendocrine tumor. Endoscopy. 47, E127-128 (2015).","DOI":"10.1055\/s-0034-1391339"},{"key":"60941_CR29","doi-asserted-by":"publisher","first-page":"202","DOI":"10.1067\/mge.2001.116564","volume":"54","author":"DJ Desilets","year":"2001","unstructured":"Desilets, D. J. et al. Endoscopic management of tumors of the major duodenal papilla: Refined techniques to improve outcome and avoid complications. Gastrointest. Endosc. 54, 202\u2013208 (2001).","journal-title":"Gastrointest. Endosc."},{"key":"60941_CR30","doi-asserted-by":"publisher","first-page":"371","DOI":"10.1016\/j.gie.2005.04.021","volume":"62","author":"J Baillie","year":"2005","unstructured":"Baillie, J. Endoscopic ampullectomy: does pancreatic stent placement make it safer? Gastrointest. Endosc. 62, 371\u2013373 (2005).","journal-title":"Gastrointest. Endosc."},{"key":"60941_CR31","doi-asserted-by":"publisher","first-page":"897","DOI":"10.1111\/jgh.13205","volume":"31","author":"TY Lee","year":"2016","unstructured":"Lee, T. Y. et al. Endoscopic wire-guided papillectomy versus conventional papillectomy for ampullary tumors: a prospective comparative pilot study. J. Gastroenterol. Hepatol. 31, 897\u2013902 (2016).","journal-title":"J. Gastroenterol. Hepatol."},{"key":"60941_CR32","doi-asserted-by":"publisher","first-page":"461","DOI":"10.1016\/S0016-5107(04)02649-5","volume":"61","author":"JH Moon","year":"2005","unstructured":"Moon, J. H. et al. Wire-guided endoscopic snare papillectomy for tumors of the major duodenal papilla. Gastrointest. Endosc. 61, 461\u2013466 (2005).","journal-title":"Gastrointest. Endosc."},{"key":"60941_CR33","doi-asserted-by":"publisher","first-page":"838","DOI":"10.1055\/s-0033-1344392","volume":"45","author":"SH Kim","year":"2013","unstructured":"Kim, S. H. et al. Usefulness of pancreatic duct wire-guided endoscopic papillectomy for ampullary adenoma for preventing post-procedure pancreatitis. Endoscopy. 45, 838\u2013841 (2013).","journal-title":"Endoscopy."},{"key":"60941_CR34","first-page":"587","volume":"15","author":"W Attaallah","year":"2014","unstructured":"Attaallah, W., Gunal, O., Mokhtare, S., Ozmen, T. & Cingi, A. Endoscopic snare excision of adenoma of the papilla of Vater without prophylactic pancreatic-duct stent. JOP. 15, 587\u2013590 (2014).","journal-title":"JOP."},{"key":"60941_CR35","doi-asserted-by":"publisher","first-page":"799","DOI":"10.1055\/s-0034-1377875","volume":"46","author":"JM Dumonceau","year":"2014","unstructured":"Dumonceau, J. M. et al. Prophylaxis of post-ERCP pancreatitis: European Society of Gastrointestinal Endoscopy (ESGE) Guideline \u2013 Updated June 2014. Endoscopy. 46, 799\u2013815 (2014).","journal-title":"Endoscopy."}],"container-title":["Scientific Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41598-020-60941-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-020-60941-3","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-020-60941-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,12,6]],"date-time":"2022-12-06T07:34:13Z","timestamp":1670312053000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41598-020-60941-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,3,5]]},"references-count":35,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2020,12]]}},"alternative-id":["60941"],"URL":"https:\/\/doi.org\/10.1038\/s41598-020-60941-3","relation":{},"ISSN":["2045-2322"],"issn-type":[{"value":"2045-2322","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,3,5]]},"assertion":[{"value":"5 August 2019","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 February 2020","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"5 March 2020","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Drs. Eloy Taglieri, Ot\u00e1vio Micelli-Neto, Eduardo Bonin, Suzan Goldman, Rafael Kemp, Jos\u00e9 Sebasti\u00e3o dos Santos and Jos\u00e9 Celso Ardengh have no conflicts of interest or financial ties to disclose.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"4132"}}