{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T11:17:13Z","timestamp":1792840633235,"version":"4.5.0"},"reference-count":62,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2020,3,5]],"date-time":"2020-03-05T00:00:00Z","timestamp":1583366400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2020,3,5]],"date-time":"2020-03-05T00:00:00Z","timestamp":1583366400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Exposure to chloromethylisothiazolinone\/methylisothiazolinone (CMIT\/MIT) has been associated with allergic contact dermatitis and occupational asthma. Despite this association however, no study has investigated the effects of CMIT\/MIT exposure on the development of atopic dermatitis (AD). This study was conducted to investigate the influence of epicutaneous exposure to CMIT\/MIT on AD in a mouse model and the underlying biological mechanisms. BALB\/C mice were exposed to CMIT\/MIT for 3 weeks and AD was developed using ovalbumin (OVA) epidermal sensitization. CMIT\/MIT epicutaneous exposure in normal mice significantly enhanced AD-like phenotypes (e.g., transepidermal water loss, clinical score, total serum immunoglobulin E level and infiltration of inflammatory cells). In addition, CMIT\/MIT exposure significantly augmented the mRNA expression level of T helper (Th) 2-related cytokines (thymic stromal lymphopoietin, interleukin (IL)-6 and IL-13), Th2 chemokine (chemokine (C-C motif) ligand 17) and the population of CD4\n                    <jats:sup>+<\/jats:sup>\n                    IL-4\n                    <jats:sup>+<\/jats:sup>\n                    cells in the skin. Moreover, mice exposed to CMIT\/MIT in the OVA challenge had greater AD-like phenotypes, higher IL-4 and IL-17A skin mRNA expression levels, and a larger population of CD4\n                    <jats:sup>+<\/jats:sup>\n                    IL-4\n                    <jats:sup>+<\/jats:sup>\n                    - and IL-17A\n                    <jats:sup>+<\/jats:sup>\n                    -producing cells in the skin-draining lymph nodes. Our current findings in a mouse model thus suggest that CMIT\/MIT exposure may cause AD symptoms through the dysregulation of Th2\/Th17-related immune responses.\n                  <\/jats:p>","DOI":"10.1038\/s41598-020-60966-8","type":"journal-article","created":{"date-parts":[[2020,3,5]],"date-time":"2020-03-05T06:06:26Z","timestamp":1583388386000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":31,"title":["Effects of chloromethylisothiazolinone\/methylisothiazolinone (CMIT\/MIT) on Th2\/Th17-related immune modulation in an atopic dermatitis mouse model"],"prefix":"10.1038","volume":"10","author":[{"given":"Han-Na","family":"Go","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seung-Hwa","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyun-Ju","family":"Cho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jae-Rin","family":"Ahn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mi-Jin","family":"Kang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"So-Yeon","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soo-Jong","family":"Hong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2020,3,5]]},"reference":[{"key":"60966_CR1","doi-asserted-by":"publisher","first-page":"S128","DOI":"10.1016\/j.jaci.2003.09.032","volume":"112","author":"N Novak","year":"2003","unstructured":"Novak, N., Bieber, T. & Leung, D. 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