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Sharing data between hospitals is restricted by legal and ethical regulations. Distributed learning is a technique, enabling training models on multicenter data without data leaving the hospitals (\u201cprivacy-preserving\u201d distributed learning). This study tested feasibility of distributed learning of radiomics data for prediction of two year overall survival and HPV status in head and neck cancer (HNC) patients. Pretreatment CT images were collected from 1174 HNC patients in 6 different cohorts. 981 radiomic features were extracted using Z-Rad software implementation. Hierarchical clustering was performed to preselect features. Classification was done using logistic regression. In the validation dataset, the receiver operating characteristics (ROC) were compared between the models trained in the centralized and distributed manner. No difference in ROC was observed with respect to feature selection. The logistic regression coefficients were identical between the methods (absolute difference &lt;10<jats:sup>\u22127<\/jats:sup>). In comparison of the full workflow (feature selection and classification), no significant difference in ROC was found between centralized and distributed models for both studied endpoints (DeLong p\u2009&gt;\u20090.05). In conclusion, both feature selection and classification are feasible in a distributed manner using radiomics data, which opens new possibility for training more reliable radiomics models.<\/jats:p>","DOI":"10.1038\/s41598-020-61297-4","type":"journal-article","created":{"date-parts":[[2020,3,11]],"date-time":"2020-03-11T11:03:11Z","timestamp":1583924591000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":61,"title":["Privacy-preserving distributed learning of radiomics to predict overall survival and HPV status in head and neck cancer"],"prefix":"10.1038","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4747-5375","authenticated-orcid":false,"given":"Marta","family":"Bogowicz","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arthur","family":"Jochems","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timo M.","family":"Deist","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephanie","family":"Tanadini-Lang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8072-4388","authenticated-orcid":false,"given":"Shao Hui","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Biu","family":"Chan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John N.","family":"Waldron","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8610-4908","authenticated-orcid":false,"given":"Scott","family":"Bratman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian","family":"O\u2019Sullivan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oliver","family":"Riesterer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriela","family":"Studer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan","family":"Unkelbach","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samir","family":"Barakat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruud H.","family":"Brakenhoff","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irene","family":"Nauta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvia E.","family":"Gazzani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppina","family":"Calareso","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathrin","family":"Scheckenbach","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank","family":"Hoebers","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frederik W. 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Dr. Lambin is inventor of two patents on radiomics and one non patentable invention (softwares), licensed to Oncoradiomics SA and has (minority) shares in the company Oncoradiomics SA. Dr. Jochems has (minority) shares in the company Oncoradiomics SA. Dr. Barakat is an employee of ptTheragnostic and Oncoradiomics SA. Dr. Leijenaar has shares in, and is Chief Technology Officer of, the company Oncoradioomics SA. He is co-inventor of an issued patent with royalties related to radiomics (PTC\/NL2014\/050728) licensed to Oncoradiomics. Dr. Bogowicz, Dr. Deist, Dr. Tanadini-Lang, Dr. Huang, Dr. Chan, Dr. Waldron, Dr. Bratman, Dr. O\u2019Sullivan, Dr. Riesterer, Dr. Studer, Dr. Unkelbach, Dr. Brakenhoff, Dr. Nauta, Dr. Gazzani, Dr. Calareso, Dr. Scheckenbach, Dr. Hoebers, Dr. Wesseling, Dr. Keek, Dr. Sanduleanu, Dr. Vergeer, Dr. Leemans, Dr. Terhaard, Dr. van den Brekel, Dr. Hamming-Vrieze, and Dr. van der Heijden, Dr. Elhalawani, Dr. Fuller and Dr. Guckenberger declare no potential conflict of interest.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"4542"}}