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The aim of this study was to evaluate retinal changes indicating neurodegenerative processes in patients with end-stage renal disease (ESRD) compared to healthy controls. This was a cross-sectional, single-center study comprising 32 ESRD patients and 38 controls. Sectoral retinal nerve fiber layer (RNFL) thickness and retinal layer volumes were obtained by SD-OCT. Age- and gender-adjusted retinal layer volumes such as total retinal volume (p\u2009=\u20090.037), ganglion cell layer volume (GCL, p\u2009=\u20090.003), ganglion cell layer \u2013 inner plexiform layer volume (GCL-IPL, p\u2009=\u20090.005) and inner retinal layer volume (IRL, p\u2009=\u20090.042) of the right eye were lower in ESRD patients. Inner plexiform layer volume of both eyes (IPL, right eye: p\u2009=\u20090.017; left eye: 0.044) was reduced, as was RNFL thickness in the temporal superior sector (right eye: p\u2009=\u20090.016). A subgroup analysis excluding patients with diabetes revealed that GCL (p\u2009=\u20090.014) and GCL-IPL volume of the right eye (p\u2009=\u20090.024) and temporal superior sector of the RNFL scan (p\u2009=\u20090.021) in ESRD patients were still significantly thinner. We observed a decrease in several retinal layer volumes and temporal RNFL thickness indicative of retinal neurodegenerative processes in patients with ESRD.<\/jats:p>","DOI":"10.1038\/s41598-020-61308-4","type":"journal-article","created":{"date-parts":[[2020,3,24]],"date-time":"2020-03-24T11:06:27Z","timestamp":1585047987000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Retinal neurodegeneration in patients with end-stage renal disease assessed by spectral-domain optical coherence tomography"],"prefix":"10.1038","volume":"10","author":[{"given":"Susanne","family":"Jung","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Agnes","family":"Bosch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Ott","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dennis","family":"Kannenkeril","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Dienemann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0124-0543","authenticated-orcid":false,"given":"Joanna M.","family":"Harazny","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Georg","family":"Michelson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roland E.","family":"Schmieder","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2020,3,24]]},"reference":[{"key":"61308_CR1","doi-asserted-by":"publisher","first-page":"2278","DOI":"10.1016\/S0161-6420(00)00341-9","volume":"107","author":"EZ Blumenthal","year":"2000","unstructured":"Blumenthal, E. 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