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Whereas appropriate and inappropriate ICD shocks lead to myocardial microdamage, this is not known for antitachycardia pacing (ATP). In total, 150 ICD recipients (66\u2009\u00b1\u200912 years, 81.3% male, 93.3% primary prevention, 30.0% resynchronization therapy) were randomly assigned to an ICD implantation with or without intraoperative ATP. In the group with ATP, the pacing maneuver was performed twice, each time applying 8 impulses \u00e0 6 Volt x 1.0 milliseconds to the myocardium. High sensitive Troponin T (hsTnT) levels were determined prior to the implantation and thereafter. There was no significant difference in the release of hsTnT between the two randomization groups (delta TnT without ATP in median 0.010\u2009ng\/ml [min. \u22120.016\u2009ng\/ml\u2013max. 0.075\u2009ng\/ml] vs. with ATP in median 0.013\u2009ng\/ml [min. \u22120.005\u20130.287\u2009ng\/ml], p\u2009=\u20090.323). Setting a hsTnT cutoff of 0.059\u2009ng\/dl as a regularly augmented postoperative hsTnT level, no relevant difference between the two groups regarding the postoperative hsTnT levels above this cutoff could be identified (without ATP n\u2009=\u200910 [14.7%] vs. with ATP n\u2009=\u200916 [21.9%], p\u2009=\u20090.287). There was no significant difference in the release of high sensitive Troponin between patients without intraoperative ATP compared to those with intraoperative ATP. Hence, antitachycardia pacing does not seem to cause significant myocardial microdamage. This may further support its use as a painless and efficient method to terminate ventricular tachycardia in high-risk patients.<\/jats:p>","DOI":"10.1038\/s41598-020-61625-8","type":"journal-article","created":{"date-parts":[[2020,3,16]],"date-time":"2020-03-16T11:05:42Z","timestamp":1584356742000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Myocardial Minimal Damage After Rapid Ventricular Pacing \u2013 the prospective randomized multicentre MyDate-Trial"],"prefix":"10.1038","volume":"10","author":[{"given":"Verena","family":"Semmler","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Clara","family":"Deutschmann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bernhard","family":"Haller","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1693-6474","authenticated-orcid":false,"given":"Carsten","family":"Lennerz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amir","family":"Brkic","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christian","family":"Grebmer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3335-8645","authenticated-orcid":false,"given":"Patrick","family":"Blazek","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Severin","family":"Weigand","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martin","family":"Karch","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sonia","family":"Busch","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christof","family":"Kolb","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2020,3,16]]},"reference":[{"key":"61625_CR1","doi-asserted-by":"publisher","first-page":"796","DOI":"10.1161\/hc3101.093906","volume":"104","author":"MS Wathen","year":"2001","unstructured":"Wathen, M. 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Rep."}],"container-title":["Scientific Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41598-020-61625-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-020-61625-8","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-020-61625-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,12,6]],"date-time":"2022-12-06T08:11:46Z","timestamp":1670314306000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41598-020-61625-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,3,16]]},"references-count":25,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2020,12]]}},"alternative-id":["61625"],"URL":"https:\/\/doi.org\/10.1038\/s41598-020-61625-8","relation":{},"ISSN":["2045-2322"],"issn-type":[{"type":"electronic","value":"2045-2322"}],"subject":[],"published":{"date-parts":[[2020,3,16]]},"assertion":[{"value":"15 August 2019","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"1 March 2020","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 March 2020","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"V.S. received travel support from Sorin Group and Abbott Medical. She received educational grants and training from Abbott Medical (St. Jude Medical) and Boston Scientific. P.B. received travel support from Abbott Medical and lecture honoraria from Biotronik. S.W. reports lecture honoraria from German Cardiac Society (DGK); he has received educational grants and training from Abbott Medical (St. Jude Medical) and Biotronik. M.K. reports lecture honoraria from Bristol-Myers Squibb and Bayer. C.K. reports speaker fees\/travel support from Abbott Medical, Biotronik, Boston Scientific, Bristol-Myers-Squibb, Microport, Novartis, Philips; he has participated in clinical studies supported by Abbott Medical, Biotronik, Boston Scientific, Microport and is\/has been an advisor to Biotronik and Microport. C.D., B.H., C.L., A.B., C.G. and S.B. declare no conflicts of interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"4753"}}