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While especially intraarterial administration of contrast media represents a cause of hospital-acquired acute kidney injury (AKI), targeted preventive strategies are not available. This trial investigated the feasibility and effectiveness of pre-interventional DR for preventing AKI in patients undergoing percutaneous coronary intervention (PCI). Patients were randomized to receive a formula diet containing 60% of daily energy requirement (DR group) or ad-libitum food during the 4-day-interval before PCI. Primary endpoint was change of serum creatinine 48\u2009h after PCI (\u0394creatinine). Further analyses included incidence of AKI and safety evaluation. \u0394creatinine post PCI in the DR group vs. the control group did not show any difference (DR: 0.03(\u22120.15,0.14)mg\/dL vs. control: 0.09(\u22120.03,0.22)mg\/dL;p\u2009=\u20090.797). Subgroup analyses revealed a significant beneficial impact of DR in patients that received \u2264100\u2009ml of contrast agent (DR n\u2009=\u200926: \u0394creatinine \u22120.03(\u22120.20,0.08)mg\/dL vs. control n\u2009=\u200924: \u0394creatinine 0.10(\u22120.08,0.24)mg\/dL; p\u2009=\u20090.041) and in patients with \u22642 risk factors for AKI (DR: n\u2009=\u200927; \u0394creatinine \u22120.01(\u22120.18,0.07)mg\/dL vs. control n\u2009=\u200931: \u0394creatinine 0.09(\u22120.03,0.16)mg\/dl; p\u2009=\u20090.030). Although the primary endpoint was not met, the results of this trial suggest a beneficial impact of DR in low-to-moderate risk patients.<\/jats:p>","DOI":"10.1038\/s41598-020-61895-2","type":"journal-article","created":{"date-parts":[[2020,3,23]],"date-time":"2020-03-23T11:03:40Z","timestamp":1584961420000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Dietary restriction for prevention of contrast-induced acute kidney injury in patients undergoing percutaneous coronary angiography: a randomized controlled trial"],"prefix":"10.1038","volume":"10","author":[{"given":"Franziska","family":"Grundmann","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6910-0745","authenticated-orcid":false,"given":"Roman-Ulrich","family":"M\u00fcller","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karla Johanna Ruth","family":"Hoyer-Allo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martin Richard","family":"Sp\u00e4th","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eva","family":"Passmann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ingrid","family":"Becker","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roman","family":"Pfister","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephan","family":"Baldus","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"Benzing","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Volker","family":"Burst","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2020,3,23]]},"reference":[{"key":"61895_CR1","doi-asserted-by":"publisher","first-page":"695","DOI":"10.1002\/lt.22243","volume":"17","author":"M Verweij","year":"2011","unstructured":"Verweij, M. et al. 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