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In this study, seven <jats:italic>NEIL1<\/jats:italic> SNPs and three <jats:italic>NEIL2<\/jats:italic> SNPs were selected. 400 CSCCs, 400 CIN III, and 1200 normal healthy controls were genotyped by mismatch amplification PCR. mRNA and protein expression of <jats:italic>NEIL<\/jats:italic>2 was measured in 92 freshly-obtained CSCC tumor tissues. The association between homozygote CC genotype of <jats:italic>NEIL2<\/jats:italic> rs804270 with susceptible risk was gradually increased in CIN III (OR\u2009=\u20091.44) and CSCC (OR\u2009=\u20092.22). Carriers of C-allele (GC\u2009+\u2009CC) at rs804270 had a high risk of CSCC (OR\u2009=\u20091.46). The heterozygote GT genotype of rs8191664 was also closely related to the higher risk of CINIII (OR\u2009=\u20091.59) and CSCC (OR\u2009=\u20092.54). Carriers of T-allele (GT\u2009+\u2009TT) at rs8191664 had a high risk for CIN III (OR\u2009=\u20091.55) and CSCC (OR\u2009=\u20092.34). The genotypes of <jats:italic>NEIL2<\/jats:italic> rs804270 (G\/C) and rs8191664 (G\/T) that were related to the higher risk for CIN III were CC-GG (OR\u2009=\u20091.42) and CC-GT (OR\u2009=\u20092.07). More notably, there was a greater risk for CSCC with the GC-GT (OR\u2009=\u20091.91), CC-GG (OR\u2009=\u20091.67), and CC-GT (OR\u2009=\u20096.18) genotypes. <jats:italic>NEIL2<\/jats:italic> mRNA expression in CSCCs with the rs804270-CC genotype was lower expression than those in CSCCs with the rs804270-GG and rs804270-GC genotypes. Similarly, <jats:italic>NEIL<\/jats:italic>2 protein expression was significantly decreased in CSCCs with the rs804270-CC genotype. In summary, the two genetic polymorphisms (rs804270 and rs8191664) of <jats:italic>NEIL<\/jats:italic>2 gene were significantly associated to the increased susceptibility of CIN III or CSCC. This increased susceptibility maybe due to altered <jats:italic>NEIL<\/jats:italic>2 repair activity through altered protein expression, or changed structure of the functional domain. The genotypes of GC-GT, CC-GG, and CC-GT of rs804270 and rs8191664 of <jats:italic>NEIL2<\/jats:italic> gene could act as a genetic predictive biomarker of susceptibility to CIN III and CSCC.<\/jats:p>","DOI":"10.1038\/s41598-020-62040-9","type":"journal-article","created":{"date-parts":[[2020,3,20]],"date-time":"2020-03-20T11:03:20Z","timestamp":1584702200000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Cervical carcinoma risk associate with genetic polymorphisms of NEIL2 gene in Chinese population and its significance as predictive biomarker"],"prefix":"10.1038","volume":"10","author":[{"given":"Feng","family":"Ye","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanzhi","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaojing","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qi","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huaizeng","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2020,3,20]]},"reference":[{"key":"62040_CR1","doi-asserted-by":"publisher","first-page":"7","DOI":"10.3322\/caac.21332","volume":"66","author":"RL Siegel","year":"2016","unstructured":"Siegel, R. 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