{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T20:16:23Z","timestamp":1790712983714,"version":"4.1.0"},"reference-count":16,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2020,3,27]],"date-time":"2020-03-27T00:00:00Z","timestamp":1585267200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2020,3,27]],"date-time":"2020-03-27T00:00:00Z","timestamp":1585267200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Anaesthetics used during cancer surgery may influence tumour cells and immunological response. The aim of this study was to evaluate a potential influence of the anaesthetic method (inhaled anaesthetics versus total-intravenous anaesthesia using propofol) on recurrence-free and overall survival in glioblastoma patients. We retrospectively identified patients undergoing resection of contrast enhancing glioblastoma under general anaesthesia followed by standard adjuvant treatment between January 2010 and February 2017 at two University Hospitals. Matched pairs of patients receiving either balanced with volatile anaesthetics or total intravenous anaesthesia were generated according to the known prognostic factors (extent of resection, methyl-guanine-methyl-transferase (MGMT) promoter methylation, age, Karnofsky performance score). Groups were compared using chi-square and Whitney-Man-U test. Time to recurrence was calculated using Kaplan Meier estimates. Log Rank test was used to assess the influence of the anaesthetic method. One hundred and fifty-eight (79:79) patients were included. Groups showed no significant difference in recurrence-free (volatiles: 8.0 (95% CI 6.5\u20139.8) vs. propofol: 8.4 (95% CI 7.9\u201310.1) months; p\u2009=\u20090.54) or overall survival (propofol: 17.4 (95% CI 14.0\u201320.7) vs. volatiles: 16.9 (95% CI 13.9\u201320.1) months; p\u2009=\u20090.85). In contrast to potential beneficial effects in some other solid tumours, the choice of anaesthetic method had no impact on survival in patients with glioblastoma in a well-defined cohort.<\/jats:p>","DOI":"10.1038\/s41598-020-62087-8","type":"journal-article","created":{"date-parts":[[2020,3,27]],"date-time":"2020-03-27T07:03:11Z","timestamp":1585292591000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["The choice of anaesthesia for glioblastoma surgery does not impact the time to recurrence"],"prefix":"10.1038","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9742-527X","authenticated-orcid":false,"given":"Stefan J.","family":"Grau","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mario","family":"L\u00f6hr","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valeria","family":"Taurisano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Herbert","family":"Trautner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Timmer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephanie G.","family":"Schwab","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00fcrgen","family":"Hampl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2496-4432","authenticated-orcid":false,"given":"Thorsten","family":"Annecke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2020,3,27]]},"reference":[{"issue":"3","key":"62087_CR1","doi-asserted-by":"publisher","first-page":"262","DOI":"10.1016\/j.jclinane.2015.02.007","volume":"27","author":"F Cassinello","year":"2015","unstructured":"Cassinello, F., Prieto, I., del Olmo, M., Rivas, S. & Strichartz, G. R. Cancer surgery: how may anesthesia influence outcome? J Clin Anesth. 27(3), 262\u2013272, https:\/\/doi.org\/10.1016\/j.jclinane.2015.02.007 (2015).","journal-title":"J Clin Anesth."},{"issue":"7","key":"62087_CR2","doi-asserted-by":"publisher","first-page":"517","DOI":"10.1016\/j.jclinane.2004.12.017","volume":"17","author":"CE Schneemilch","year":"2005","unstructured":"Schneemilch, C. E., Ittenson, A., Ansorge, S., Hachenberg, T. & Bank, U. Effect of 2 anesthetic techniques on the postoperative proinflammatory and anti-inflammatory cytokine response and cellular immune function to minor surgery. J Clin Anesth. 17(7), 517\u2013527, https:\/\/doi.org\/10.1016\/j.jclinane.2004.12.017 (2005).","journal-title":"J Clin Anesth."},{"issue":"5","key":"62087_CR3","doi-asserted-by":"publisher","first-page":"1383","DOI":"10.1213\/ANE.0000000000001779","volume":"124","author":"JP Cata","year":"2017","unstructured":"Cata, J. P. 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Best Pract Res Clin Anaesthesiol. 27(4), 441\u2013456, https:\/\/doi.org\/10.1016\/j.bpa.2013.10.005 (2013).","journal-title":"Best Pract Res Clin Anaesthesiol."},{"issue":"9","key":"62087_CR14","doi-asserted-by":"publisher","first-page":"733","DOI":"10.1017\/S0265021507000531","volume":"24","author":"G Minguet","year":"2007","unstructured":"Minguet, G., Joris, J. & Lamy, M. Preconditioning and protection against ischaemia-reperfusion in non-cardiac organs: a place for volatile anaesthetics? Eur J Anaesthesiol. 24(9), 733\u2013745, https:\/\/doi.org\/10.1017\/S0265021507000531 (2007).","journal-title":"Eur J Anaesthesiol."},{"key":"62087_CR15","doi-asserted-by":"publisher","first-page":"82","DOI":"10.1016\/j.jocn.2016.10.006","volume":"35","author":"JP Cata","year":"2017","unstructured":"Cata, J. P. et al. The use of isoflurane and desflurane as inhalational agents for glioblastoma surgery. A survival analysis. 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