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However, difficulties in obtaining a reliable measure of sympathetic activity from HRV spectra limits the exploitation of sympatho-vagal metrics. On the other hand, measures of electrodermal activity (EDA) have been demonstrated to provide a reliable quantifier of sympathetic dynamics. In this study we propose novel indices of phasic autonomic regulation mechanisms by combining HRV and EDA correlates and thoroughly investigating their time-varying dynamics. HRV and EDA series were gathered from 26 healthy subjects during a cold-pressor test and emotional stimuli. Instantaneous linear and nonlinear (bispectral) estimates of vagal dynamics were obtained from HRV through inhomogeneous point-process models, and combined with a sensitive maker of sympathetic tone from EDA spectral power. A wavelet decomposition analysis was applied to estimate phasic components of the proposed sympatho-vagal indices. Results show significant statistical differences for the proposed indices between the cold-pressor elicitation and previous resting state. Furthermore, an accuracy of 73.08% was achieved for the automatic emotional valence recognition. The proposed nonlinear processing of phasic ANS markers brings novel insights on autonomic functioning that can be exploited in the field of affective computing and psychophysiology.<\/jats:p>","DOI":"10.1038\/s41598-020-62225-2","type":"journal-article","created":{"date-parts":[[2020,3,25]],"date-time":"2020-03-25T11:03:32Z","timestamp":1585134212000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":122,"title":["Assessing Autonomic Function from Electrodermal Activity and Heart Rate Variability During Cold-Pressor Test and Emotional Challenge"],"prefix":"10.1038","volume":"10","author":[{"given":"Shadi","family":"Ghiasi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4822-5562","authenticated-orcid":false,"given":"Alberto","family":"Greco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9381-3833","authenticated-orcid":false,"given":"Riccardo","family":"Barbieri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2588-4917","authenticated-orcid":false,"given":"Enzo Pasquale","family":"Scilingo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gaetano","family":"Valenza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2020,3,25]]},"reference":[{"key":"62225_CR1","doi-asserted-by":"publisher","first-page":"513","DOI":"10.1152\/physrev.00007.2009","volume":"90","author":"SC Malpas","year":"2010","unstructured":"Malpas, S. 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