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The aim of this research was to investigate the effects of unicornuate uterine anomaly on twin pregnancies after <jats:italic>in vitro<\/jats:italic> fertilization-embryo transfer (IVF-ET). A total of 206 women with unicornuate uteri (A singleton, B selective reduction (SR) of twins to a singleton, C twins) and 314 women with normal uteri (D SR of twins to a singleton, E twins) who delivered at \u226522 weeks were included. C was associated with a significantly lower live birth rate (adjusted odds ratio (aOR) 0.08, 95% confidence interval (CI), 0.01\u20130.69) and higher risks of preterm delivery (aOR 11.63, 95% CI, 4.85\u201327.92), perinatal mortality (aOR 11.43, 95% CI, 1.44\u201390.57) and low birth weight (aOR 5.92, 95% CI 1.94\u201318.06) than A, a 15-fold greater risk of preterm delivery (aOR 15.54, 95% CI 3.09\u201378.28) than B and a greater risk of preterm delivery (aOR 2.76, 95% CI 1.33\u20135.73) than E. After SR to a singleton, the perinatal outcomes were statistically similar between B and D. These results showed that the risk of twin pregnancies should be minimized in patients with unicornuate uterine anomaly undergoing IVF-ET.<\/jats:p>","DOI":"10.1038\/s41598-020-62311-5","type":"journal-article","created":{"date-parts":[[2020,3,27]],"date-time":"2020-03-27T11:03:11Z","timestamp":1585306991000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["The risk of twin pregnancies should be minimized in patients with a unicornuate uterus undergoing IVF-ET"],"prefix":"10.1038","volume":"10","author":[{"given":"Yan","family":"Ouyang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pei","family":"Cai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fei","family":"Gong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ge","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiabi","family":"Qin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xihong","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2020,3,27]]},"reference":[{"key":"62311_CR1","doi-asserted-by":"publisher","first-page":"761","DOI":"10.1093\/humupd\/dmr028","volume":"17","author":"YY Chan","year":"2011","unstructured":"Chan, Y. 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