{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,8]],"date-time":"2026-04-08T04:57:41Z","timestamp":1775624261942,"version":"3.50.1"},"reference-count":47,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2020,3,30]],"date-time":"2020-03-30T00:00:00Z","timestamp":1585526400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2020,3,30]],"date-time":"2020-03-30T00:00:00Z","timestamp":1585526400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Interleukin (IL)-17A is a well-described mediator of bone resorption in inflammatory diseases, and postmenopausal osteoporosis is associated with increased serum levels of IL-17A. Ovariectomy (OVX) can be used as a model to study bone loss induced by estrogen deficiency and the role of IL-17A in osteoporosis development has previously been investigated using various methods to inhibit IL-17A signaling in this model. However, the studies show opposing results. While some publications reported IL-17A as a mediator of OVX-induced osteoporosis, others found a bone-protective role for IL-17 receptor signaling. In this study, we provide an explanation for the discrepancies in previous literature and show for the first time that loss of IL-17A has differential effects on OVX-induced osteoporosis; with IL-17A being important for cortical but not trabecular bone loss. Interestingly, the decrease in trabecular bone after OVX in IL-17A knock-out mice, was accompanied by increased adipogenesis depicted by elevated leptin levels. Additionally, the bone marrow adipose tissue expanded, and the bone-turnover decreased in ovariectomized mice lacking IL-17A compared to ovariectomized WT mice. Our results increase the understanding of how IL-17A signaling influences bone remodeling in the different bone compartments, which is\u00a0of importance for the development of new treatments of post-menopausal osteoporosis.<\/jats:p>","DOI":"10.1038\/s41598-020-62562-2","type":"journal-article","created":{"date-parts":[[2020,3,30]],"date-time":"2020-03-30T10:04:00Z","timestamp":1585562640000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Interleukin 17A: a Janus-faced regulator of osteoporosis"],"prefix":"10.1038","volume":"10","author":[{"given":"J. M.","family":"Scheffler","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.","family":"Grahnemo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Engdahl","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Drevinge","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K. L.","family":"Gustafsson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Corciulo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.","family":"Lawenius","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y.","family":"Iwakura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.","family":"Sj\u00f6gren","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. K.","family":"Lagerquist","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.","family":"Carlsten","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Ohlsson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"U.","family":"Islander","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2020,3,30]]},"reference":[{"key":"62562_CR1","doi-asserted-by":"publisher","first-page":"1501","DOI":"10.1126\/science.289.5484.1501","volume":"289","author":"P Ducy","year":"2000","unstructured":"Ducy, P., Schinke, T. & Karsenty, G. The osteoblast: a sophisticated fibroblast under central surveillance. Science 289, 1501\u20131504, https:\/\/doi.org\/10.1126\/science.289.5484.1501 (2000).","journal-title":"Science"},{"key":"62562_CR2","doi-asserted-by":"publisher","first-page":"1504","DOI":"10.1126\/science.289.5484.1504","volume":"289","author":"SL Teitelbaum","year":"2000","unstructured":"Teitelbaum, S. L. Bone Resorption by Osteoclasts. Science 289, 1504\u20131508, https:\/\/doi.org\/10.1126\/science.289.5484.1504 (2000).","journal-title":"Science"},{"key":"62562_CR3","doi-asserted-by":"publisher","first-page":"2465","DOI":"10.1001\/jama.1941.02820220007002","volume":"116","author":"F Albright","year":"1941","unstructured":"Albright, F., Smith, P. H. & Richardson, A. M. Postmenopausal osteoporosis: its clinical features. JAMA 116, 2465\u20132474, https:\/\/doi.org\/10.1001\/jama.1941.02820220007002 (1941).","journal-title":"JAMA"},{"key":"62562_CR4","doi-asserted-by":"crossref","unstructured":"Effects of hormone therapy on bone mineral density: results from the postmenopausal estrogen\/progestin interventions (PEPI) trial. The Writing Group for the PEPI. Jama 276, 1389\u20131396 (1996).","DOI":"10.1001\/jama.276.17.1389"},{"key":"62562_CR5","doi-asserted-by":"publisher","first-page":"2265","DOI":"10.1001\/jama.2017.18440","volume":"318","author":"J Jin","year":"2017","unstructured":"Jin, J. Hormone Therapy for Primary Prevention of Chronic Conditions in Postmenopausal WomenHormone Therapy for Prevention of Chronic Conditions in Postmenopausal WomenHormone Therapy for Prevention of Chronic Conditions in Postmenopausal Women. JAMA 318, 2265\u20132265, https:\/\/doi.org\/10.1001\/jama.2017.18440 (2017).","journal-title":"JAMA"},{"key":"62562_CR6","doi-asserted-by":"publisher","first-page":"4367","DOI":"10.1210\/endo.140.9.7131","volume":"140","author":"LC Hofbauer","year":"1999","unstructured":"Hofbauer, L. C. et al. Estrogen stimulates gene expression and protein production of osteoprotegerin in human osteoblastic cells. Endocrinology 140, 4367\u20134370, https:\/\/doi.org\/10.1210\/endo.140.9.7131 (1999).","journal-title":"Endocrinology"},{"issue":"Suppl 1","key":"62562_CR7","doi-asserted-by":"publisher","first-page":"E31","DOI":"10.1111\/j.1749-6632.2009.04954.x","volume":"1173","author":"Y Imai","year":"2009","unstructured":"Imai, Y. et al. Estrogens maintain bone mass by regulating expression of genes controlling function and life span in mature osteoclasts. Ann. N. Y. Acad. Sci. 1173(Suppl 1), E31\u201339, https:\/\/doi.org\/10.1111\/j.1749-6632.2009.04954.x (2009).","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"62562_CR8","doi-asserted-by":"publisher","unstructured":"Fujiwara, Y. et al. RANKL produced by osteocytes is required for the increase in B cells and bone loss caused by estrogen deficiency in mice. Journal of Biological Chemistry, https:\/\/doi.org\/10.1074\/jbc.M116.742452 (2016).","DOI":"10.1074\/jbc.M116.742452"},{"key":"62562_CR9","doi-asserted-by":"publisher","first-page":"756","DOI":"10.1056\/NEJMoa0809493","volume":"361","author":"SR Cummings","year":"2009","unstructured":"Cummings, S. R. et al. Denosumab for Prevention of Fractures in Postmenopausal Women with Osteoporosis. N. Engl. J. Med. 361, 756\u2013765, https:\/\/doi.org\/10.1056\/NEJMoa0809493 (2009).","journal-title":"N. Engl. J. Med."},{"key":"62562_CR10","doi-asserted-by":"publisher","first-page":"724","DOI":"10.1359\/jbmr.070207","volume":"22","author":"N Charatcharoenwitthaya","year":"2007","unstructured":"Charatcharoenwitthaya, N., Khosla, S., Atkinson, E. J., McCready, L. K. & Riggs, B. L. Effect of Blockade of TNF-\u03b1 and Interleukin-1 Action on Bone Resorption in Early Postmenopausal Women. J. Bone Miner. Res. 22, 724\u2013729, https:\/\/doi.org\/10.1359\/jbmr.070207 (2007).","journal-title":"J. Bone Miner. Res."},{"key":"62562_CR11","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1016\/S0378-5122(96)01080-8","volume":"26","author":"SX Zheng","year":"1997","unstructured":"Zheng, S. X. et al. Increase in cytokine production (IL-1\u03b2, IL-6, TNF-\u03b1 but not IFN-\u03b3, GM-CSF or LIF) by stimulated whole blood cells in postmenopausal osteoporosis. Maturitas 26, 63\u201371, https:\/\/doi.org\/10.1016\/S0378-5122(96)01080-8 (1997).","journal-title":"Maturitas"},{"key":"62562_CR12","doi-asserted-by":"publisher","first-page":"5134","DOI":"10.1073\/pnas.88.12.5134","volume":"88","author":"R Pacifici","year":"1991","unstructured":"Pacifici, R. et al. Effect of surgical menopause and estrogen replacement on cytokine release from human blood mononuclear cells. Proc. Natl Acad. Sci. 88, 5134\u20135138, https:\/\/doi.org\/10.1073\/pnas.88.12.5134 (1991).","journal-title":"Proc. Natl Acad. Sci."},{"key":"62562_CR13","doi-asserted-by":"publisher","first-page":"183","DOI":"10.3109\/09513590.2014.975683","volume":"31","author":"J Zhang","year":"2015","unstructured":"Zhang, J. et al. Changes of serum cytokines-related Th1\/Th2\/Th17 concentration in patients with postmenopausal osteoporosis. Gynecol. Endocrinol. 31, 183\u2013190, https:\/\/doi.org\/10.3109\/09513590.2014.975683 (2015).","journal-title":"Gynecol. Endocrinol."},{"key":"62562_CR14","doi-asserted-by":"publisher","first-page":"1627","DOI":"10.1902\/jop.2013.120595","volume":"84","author":"P Gumus","year":"2013","unstructured":"Gumus, P. et al. Gingival crevicular fluid, serum levels of receptor activator of nuclear factor-kappaB ligand, osteoprotegerin, and interleukin-17 in patients with rheumatoid arthritis and osteoporosis and with periodontal disease. J. Periodontol. 84, 1627\u20131637, https:\/\/doi.org\/10.1902\/jop.2013.120595 (2013).","journal-title":"J. Periodontol."},{"key":"62562_CR15","doi-asserted-by":"publisher","first-page":"2655","DOI":"10.4049\/jimmunol.170.5.2655","volume":"170","author":"E Lubberts","year":"2003","unstructured":"Lubberts, E. et al. IL-17 promotes bone erosion in murine collagen-induced arthritis through loss of the receptor activator of NF-kappa B ligand\/osteoprotegerin balance. J. Immunol. 170, 2655\u20132662 (2003).","journal-title":"J. Immunol."},{"key":"62562_CR16","doi-asserted-by":"publisher","first-page":"1981","DOI":"10.1002\/jbmr.2228","volume":"29","author":"AM Tyagi","year":"2014","unstructured":"Tyagi, A. M. et al. Enhanced immunoprotective effects by anti-IL-17 antibody translates to improved skeletal parameters under estrogen deficiency compared with anti-RANKL and anti-TNF-alpha antibodies. J. Bone Min. Res. 29, 1981\u20131992, https:\/\/doi.org\/10.1002\/jbmr.2228 (2014).","journal-title":"J. Bone Min. Res."},{"key":"62562_CR17","doi-asserted-by":"publisher","first-page":"e44552","DOI":"10.1371\/journal.pone.0044552","volume":"7","author":"AM Tyagi","year":"2012","unstructured":"Tyagi, A. M. et al. Estrogen deficiency induces the differentiation of IL-17 secreting Th17 cells: a new candidate in the pathogenesis of osteoporosis. PLoS One 7, e44552, https:\/\/doi.org\/10.1371\/journal.pone.0044552 (2012).","journal-title":"PLoS One"},{"key":"62562_CR18","doi-asserted-by":"publisher","first-page":"2049","DOI":"10.1172\/JCI86062","volume":"126","author":"J-Y Li","year":"2016","unstructured":"Li, J.-Y. et al. Sex steroid deficiency\u2013associated bone loss is microbiota dependent and prevented by probiotics. J. Clin. Investigation 126, 2049\u20132063, https:\/\/doi.org\/10.1172\/JCI86062 (2016).","journal-title":"J. Clin. Investigation"},{"key":"62562_CR19","doi-asserted-by":"publisher","first-page":"2895","DOI":"10.1002\/jcb.24165","volume":"113","author":"CJ DeSelm","year":"2012","unstructured":"DeSelm, C. J. et al. IL-17 mediates estrogen-deficient osteoporosis in an Act1-dependent manner. J. Cell. Biochem. 113, 2895\u20132902, https:\/\/doi.org\/10.1002\/jcb.24165 (2012).","journal-title":"J. Cell. Biochem."},{"key":"62562_CR20","doi-asserted-by":"publisher","first-page":"2831","DOI":"10.1002\/eji.200939670","volume":"39","author":"J Goswami","year":"2009","unstructured":"Goswami, J., Hernandez-Santos, N., Zuniga, L. A. & Gaffen, S. L. A bone-protective role for IL-17 receptor signaling in ovariectomy-induced bone loss. Eur. J. Immunol. 39, 2831\u20132839, https:\/\/doi.org\/10.1002\/eji.200939670 (2009).","journal-title":"Eur. J. Immunol."},{"key":"62562_CR21","doi-asserted-by":"publisher","first-page":"375","DOI":"10.1016\/S1074-7613(02)00391-6","volume":"17","author":"S Nakae","year":"2002","unstructured":"Nakae, S. et al. Antigen-specific T cell sensitization is impaired in IL-17-deficient mice, causing suppression of allergic cellular and humoral responses. Immunity 17, 375\u2013387 (2002).","journal-title":"Immunity"},{"key":"62562_CR22","doi-asserted-by":"publisher","first-page":"895","DOI":"10.1172\/JCI6730","volume":"104","author":"SH Windahl","year":"1999","unstructured":"Windahl, S. H., Vidal, O., Andersson, G., Gustafsson, J. A. & Ohlsson, C. Increased cortical bone mineral content but unchanged trabecular bone mineral density in female ER\u03b2\u2013\/\u2013 mice. J. Clin. Investigation 104, 895\u2013901, https:\/\/doi.org\/10.1172\/JCI6730 (1999).","journal-title":"J. Clin. Investigation"},{"key":"62562_CR23","doi-asserted-by":"crossref","unstructured":"Mov\u00e9rare-Skrtic, S. et al. Osteoblast-derived WNT16 represses osteoclastogenesis and prevents cortical bone fragility fractures. Nature Medicine 20, 1279, doi:10.1038\/nm.3654 https:\/\/www.nature.com\/articles\/nm.3654#supplementary-information (2014).","DOI":"10.1038\/nm.3654"},{"key":"62562_CR24","doi-asserted-by":"publisher","first-page":"255","DOI":"10.1007\/bf01606064","volume":"418","author":"S Toyosawa","year":"1991","unstructured":"Toyosawa, S. et al. Histochemistry of tartrate-resistant acid phosphatase and carbonic anhydrase isoenzyme II in osteoclast-like giant cells in bone tumours. Virchows Archiv. A, Pathological Anat. histopathology 418, 255\u2013261, https:\/\/doi.org\/10.1007\/bf01606064 (1991).","journal-title":"Virchows Archiv. A, Pathological Anat. histopathology"},{"key":"62562_CR25","doi-asserted-by":"publisher","first-page":"1090","DOI":"10.1172\/jci117424","volume":"94","author":"T Masuzawa","year":"1994","unstructured":"Masuzawa, T. et al. Estrogen deficiency stimulates B lymphopoiesis in mouse bone marrow. J. Clin. Invest. 94, 1090\u20131097, https:\/\/doi.org\/10.1172\/jci117424 (1994).","journal-title":"J. Clin. Invest."},{"key":"62562_CR26","doi-asserted-by":"publisher","first-page":"315","DOI":"10.1038\/16852","volume":"397","author":"Y-Y Kong","year":"1999","unstructured":"Kong, Y.-Y. et al. OPGL is a key regulator of osteoclastogenesis, lymphocyte development and lymph-node organogenesis. Nature 397, 315\u2013323, https:\/\/doi.org\/10.1038\/16852 (1999).","journal-title":"Nature"},{"key":"62562_CR27","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1007\/s00223-007-9101-6","volume":"82","author":"JP Rissanen","year":"2008","unstructured":"Rissanen, J. P. et al. Short-term changes in serum PINP predict long-term changes in trabecular bone in the rat ovariectomy model. Calcif. tissue Int. 82, 155\u2013161, https:\/\/doi.org\/10.1007\/s00223-007-9101-6 (2008).","journal-title":"Calcif. tissue Int."},{"key":"62562_CR28","doi-asserted-by":"publisher","first-page":"6947","DOI":"10.4049\/jimmunol.1001269","volume":"185","author":"LA Z\u00fa\u00f1iga","year":"2010","unstructured":"Z\u00fa\u00f1iga, L. A. et al. IL-17 regulates adipogenesis, glucose homeostasis, and obesity. J. immunology 185, 6947\u20136959, https:\/\/doi.org\/10.4049\/jimmunol.1001269 (2010).","journal-title":"J. immunology"},{"key":"62562_CR29","doi-asserted-by":"publisher","first-page":"223","DOI":"10.1017\/S0954422412000145","volume":"25","author":"A Lancha","year":"2012","unstructured":"Lancha, A., Fr\u00fchbeck, G. & G\u00f3mez-Ambrosi, J. Peripheral signalling involved in energy homeostasis control. Nutr. Res. Rev. 25, 223\u2013248, https:\/\/doi.org\/10.1017\/S0954422412000145 (2012).","journal-title":"Nutr. Res. Rev."},{"key":"62562_CR30","doi-asserted-by":"publisher","first-page":"2049","DOI":"10.1172\/jci86062","volume":"126","author":"JY Li","year":"2016","unstructured":"Li, J. Y. et al. Sex steroid deficiency-associated bone loss is microbiota dependent and prevented by probiotics. J. Clin. Invest. 126, 2049\u20132063, https:\/\/doi.org\/10.1172\/jci86062 (2016).","journal-title":"J. Clin. Invest."},{"key":"62562_CR31","doi-asserted-by":"publisher","first-page":"2895","DOI":"10.1002\/jcb.24165","volume":"113","author":"CJ DeSelm","year":"2012","unstructured":"DeSelm, C. J. et al. IL-17 mediates estrogen-deficient osteoporosis in an Act1-dependent manner. J. Cell Biochem. 113, 2895\u20132902, https:\/\/doi.org\/10.1002\/jcb.24165 (2012).","journal-title":"J. Cell Biochem."},{"key":"62562_CR32","doi-asserted-by":"publisher","first-page":"479","DOI":"10.1038\/nri2800","volume":"10","author":"DJ Cua","year":"2010","unstructured":"Cua, D. J. & Tato, C. M. Innate IL-17-producing cells: the sentinels of the immune system. Nat. Rev. Immunology 10, 479\u2013489, https:\/\/doi.org\/10.1038\/nri2800 (2010).","journal-title":"Nat. Rev. Immunology"},{"key":"62562_CR33","doi-asserted-by":"publisher","first-page":"198","DOI":"10.1186\/s13075-019-1984-x","volume":"21","author":"A Takaki-Kuwahara","year":"2019","unstructured":"Takaki-Kuwahara, A. et al. CCR6+ group 3 innate lymphoid cells accumulate in inflamed joints in rheumatoid arthritis and produce Th17 cytokines. Arthritis Res. Ther. 21, 198, https:\/\/doi.org\/10.1186\/s13075-019-1984-x (2019).","journal-title":"Arthritis Res. Ther."},{"key":"62562_CR34","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1530\/joe-18-0183","volume":"238","author":"KL Gustafsson","year":"2018","unstructured":"Gustafsson, K. L. et al. ERalpha expression in T lymphocytes is dispensable for estrogenic effects in bone. J. Endocrinol. 238, 129\u2013136, https:\/\/doi.org\/10.1530\/joe-18-0183 (2018).","journal-title":"J. Endocrinol."},{"key":"62562_CR35","doi-asserted-by":"publisher","first-page":"6173","DOI":"10.4049\/jimmunol.171.11.6173","volume":"171","author":"S Nakae","year":"2003","unstructured":"Nakae, S., Nambu, A., Sudo, K. & Iwakura, Y. Suppression of immune induction of collagen-induced arthritis in IL-17-deficient mice. J. Immunol. 171, 6173\u20136177, https:\/\/doi.org\/10.4049\/jimmunol.171.11.6173 (2003).","journal-title":"J. Immunol."},{"key":"62562_CR36","doi-asserted-by":"publisher","first-page":"661","DOI":"10.1016\/j.cmet.2017.01.001","volume":"25","author":"Y Fan","year":"2017","unstructured":"Fan, Y. et al. Parathyroid Hormone Directs Bone Marrow Mesenchymal Cell Fate. Cell Metab. 25, 661\u2013672, https:\/\/doi.org\/10.1016\/j.cmet.2017.01.001 (2017).","journal-title":"Cell Metab."},{"key":"62562_CR37","doi-asserted-by":"publisher","first-page":"2978","DOI":"10.1002\/jbmr.490","volume":"26","author":"A Muto","year":"2011","unstructured":"Muto, A. et al. Lineage-committed osteoclast precursors circulate in blood and settle down into bone. J. Bone Min. Res. 26, 2978\u20132990, https:\/\/doi.org\/10.1002\/jbmr.490 (2011).","journal-title":"J. Bone Min. Res."},{"key":"62562_CR38","doi-asserted-by":"publisher","first-page":"865","DOI":"10.4049\/jimmunol.0804080","volume":"183","author":"S von Vietinghoff","year":"2009","unstructured":"von Vietinghoff, S. & Ley, K. IL-17A Controls IL-17F Production and Maintains Blood Neutrophil Counts in Mice. J. Immunology 183, 865, https:\/\/doi.org\/10.4049\/jimmunol.0804080 (2009).","journal-title":"J. Immunology"},{"key":"62562_CR39","doi-asserted-by":"publisher","first-page":"305","DOI":"10.1016\/S0092-8674(02)01049-8","volume":"111","author":"S Takeda","year":"2002","unstructured":"Takeda, S. et al. Leptin Regulates Bone Formation via the Sympathetic Nervous System. Cell 111, 305\u2013317, https:\/\/doi.org\/10.1016\/S0092-8674(02)01049-8 (2002).","journal-title":"Cell"},{"key":"62562_CR40","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1016\/S0092-8674(00)81558-5","volume":"100","author":"P Ducy","year":"2000","unstructured":"Ducy, P. et al. Leptin Inhibits Bone Formation through a Hypothalamic Relay: A Central Control of Bone Mass. Cell 100, 197\u2013207, https:\/\/doi.org\/10.1016\/S0092-8674(00)81558-5 (2000).","journal-title":"Cell"},{"key":"62562_CR41","doi-asserted-by":"publisher","first-page":"62","DOI":"10.1007\/s11914-008-0011-y","volume":"6","author":"NJ Lee","year":"2008","unstructured":"Lee, N. J., Wong, I. P., Baldock, P. A. & Herzog, H. Leptin as an endocrine signal in bone. Curr. Osteoporos. Rep. 6, 62\u201366, https:\/\/doi.org\/10.1007\/s11914-008-0011-y (2008).","journal-title":"Curr. Osteoporos. Rep."},{"key":"62562_CR42","doi-asserted-by":"publisher","first-page":"901","DOI":"10.1016\/j.cmet.2013.04.009","volume":"17","author":"D Kajimura","year":"2013","unstructured":"Kajimura, D. et al. Adiponectin regulates bone mass via opposite central and peripheral mechanisms through FoxO1. Cell Metab. 17, 901\u2013915, https:\/\/doi.org\/10.1016\/j.cmet.2013.04.009 (2013).","journal-title":"Cell Metab."},{"key":"62562_CR43","first-page":"1524","volume":"123","author":"Y Liu","year":"2010","unstructured":"Liu, Y., Tang, G. Y., Tang, R. B., Peng, Y. F. & Li, W. Assessment of bone marrow changes in postmenopausal women with varying bone densities: magnetic resonance spectroscopy and diffusion magnetic resonance imaging. Chin. Med. J. 123, 1524\u20131527 (2010).","journal-title":"Chin. Med. J."},{"key":"62562_CR44","doi-asserted-by":"publisher","first-page":"2294","DOI":"10.1210\/jc.2012-3949","volume":"98","author":"AV Schwartz","year":"2013","unstructured":"Schwartz, A. V. et al. Vertebral bone marrow fat associated with lower trabecular BMD and prevalent vertebral fracture in older adults. J. Clin. Endocrinol. Metab. 98, 2294\u20132300, https:\/\/doi.org\/10.1210\/jc.2012-3949 (2013).","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"62562_CR45","doi-asserted-by":"publisher","first-page":"225","DOI":"10.1002\/jmri.23619","volume":"36","author":"JF Griffith","year":"2012","unstructured":"Griffith, J. F. et al. Bone marrow fat content in the elderly: a reversal of sex difference seen in younger subjects. J. Magnetic Reson. Imaging 36, 225\u2013230, https:\/\/doi.org\/10.1002\/jmri.23619 (2012).","journal-title":"J. Magnetic Reson. Imaging"},{"key":"62562_CR46","doi-asserted-by":"publisher","first-page":"1144","DOI":"10.1002\/art.40070","volume":"69","author":"FJ Blanco","year":"2017","unstructured":"Blanco, F. J. et al. Secukinumab in Active Rheumatoid Arthritis: A Phase III Randomized, Double-Blind, Active Comparator\u2013 and Placebo-Controlled Study. Arthritis Rheumatol. 69, 1144\u20131153, https:\/\/doi.org\/10.1002\/art.40070 (2017).","journal-title":"Arthritis Rheumatol."},{"key":"62562_CR47","doi-asserted-by":"publisher","first-page":"559","DOI":"10.1007\/s00223-017-0380-2","volume":"102","author":"A Paine","year":"2018","unstructured":"Paine, A. & Ritchlin, C. Altered Bone Remodeling in Psoriatic Disease: New Insights and Future Directions. Calcif. Tissue Int. 102, 559\u2013574, https:\/\/doi.org\/10.1007\/s00223-017-0380-2 (2018).","journal-title":"Calcif. Tissue Int."}],"container-title":["Scientific Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41598-020-62562-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-020-62562-2","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-020-62562-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,12,6]],"date-time":"2022-12-06T09:11:47Z","timestamp":1670317907000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41598-020-62562-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,3,30]]},"references-count":47,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2020,12]]}},"alternative-id":["62562"],"URL":"https:\/\/doi.org\/10.1038\/s41598-020-62562-2","relation":{},"ISSN":["2045-2322"],"issn-type":[{"value":"2045-2322","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,3,30]]},"assertion":[{"value":"20 December 2019","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 March 2020","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"30 March 2020","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"5692"}}