{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T16:52:23Z","timestamp":1785430343356,"version":"3.56.0"},"reference-count":20,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2020,4,24]],"date-time":"2020-04-24T00:00:00Z","timestamp":1587686400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2020,4,24]],"date-time":"2020-04-24T00:00:00Z","timestamp":1587686400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The aim of the research is to explore the relationship between hyperthyroidism, iodine, antithyroid drugs (propylthiouracil) and vascular endothelial injury. In total, 136\u2009SD rats were randomly allocated into the control group, the hyperthyroidism group, the hyperthyroidism propylthiouracil group, the hyperthyroidism low iodine group, the high iodine group, and the endothelial injury group. Rats were raised for 60 days. Afterward, indicators concerning endothelial damage were determined, including the von Willebrand Factor (vWF), thrombomodulin (TM), nitric oxide (NO), endothelin 1 (ET-1), and P-selectin, as well as the plant hemagglutinin sample type oxidized low-density lipoprotein receptor 1 (LOX-1) from the aorta and the number of endothelial progenitor cells (EPCs) in whole blood. The hyperthyroidism group had significantly higher values for vWF, TM, NO, ET-1, and P-selectin in serum and a higher number of EPCs in whole blood compared with the control group, similar to the LOX-1 expression in abdominal aorta. The hyperthyroidism low iodine group had significantly higher values for vWF, ET-1, and P-selectin in serum and a higher number of EPCs in whole blood compared with those of the control group, as was the case for LOX-1 expression in the abdominal aorta. The hyperthyroidism propylthiouracil group had significantly higher values for FT<jats:sub>4<\/jats:sub> in the serum compared with those in the control group. The electron microscope showed that hyperthyroidism caused a certain degree of endothelial injury to the abdominal aorta in rats. Hyperthyroidism can damage the vascular endothelium and is a high-risk factor for cardio-cerebrovascular disease. Propylthiouracil could be used in the treatment of hyperthyroidism, thus protecting endothelial cells from damage.<\/jats:p>","DOI":"10.1038\/s41598-020-62796-0","type":"journal-article","created":{"date-parts":[[2020,4,24]],"date-time":"2020-04-24T10:26:38Z","timestamp":1587723998000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Study on the relationship between hyperthyroidism and vascular endothelial cell damage"],"prefix":"10.1038","volume":"10","author":[{"given":"Tianlong","family":"Yu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miao","family":"Jing","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunyan","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chang","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lanchun","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haihan","family":"Jia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peng","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manli","family":"Chang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2020,4,24]]},"reference":[{"key":"62796_CR1","first-page":"4","volume":"6","author":"L Oszukowska","year":"2010","unstructured":"Oszukowska, L., Knapska-Kucharska, M. & Lewinski, A. Effects of drugs on the efficacy of radioiodine 131I therapy in hyperthyroid patients. AMS 6, 4\u201310 (2010).","journal-title":"AMS"},{"key":"62796_CR2","first-page":"48","volume":"19","author":"Z Zhiming","year":"2017","unstructured":"Zhiming, Z. The efficacy and safety of methylimidazole and propylthiouracil in the treatment of hyperthyroidism. Mod. Med. J. Chin. 19, 48\u201350 (2017).","journal-title":"Mod. Med. J. Chin."},{"key":"62796_CR3","first-page":"2560","volume":"59","author":"T Karaca","year":"2015","unstructured":"Karaca, T., Hulya, U. Y., Karabacak, R., Karaboga, I., Demirtas, S. & Cagatay, C. A. Effects of hyperthyroidism on expression of vascular endothelial growth factor (VEGF) and apoptosis in fetal adrenal glands. Ejh 59, 2560 (2015).","journal-title":"Ejh"},{"key":"62796_CR4","first-page":"606","volume":"29","author":"YE Jing","year":"2012","unstructured":"Jing, Y. E., Wang, F. J. & Zhang, H. Effects of Excessive Intake of Iodine on Activation of Endothelial Cells of Inferior Vena Cava in Rats. J. Envir Heal. 29, 606\u2013605 (2012).","journal-title":"J. Envir Heal."},{"key":"62796_CR5","doi-asserted-by":"publisher","first-page":"201","DOI":"10.1007\/s12011-015-0264-0","volume":"166","author":"M Zhang","year":"2015","unstructured":"Zhang, M. et al. Effect of Excessive Potassium Iodide on Rat Aorta Endothelial Cells. Biol. Trace Elem. Res, 166, 201\u2013209 (2015).","journal-title":"Biol. Trace Elem. Res,"},{"key":"62796_CR6","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1023\/B:MCBI.0000044371.06317.0a","volume":"264","author":"T Kondo","year":"2004","unstructured":"Kondo, T., Kobayashi, K. & Murohara, T. Nitric oxide signaling during myocardial angiogenesis. Mol. Cel. Biochem. 264, 25\u201334 (2004).","journal-title":"Mol. Cel. Biochem."},{"key":"62796_CR7","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1159\/000159039","volume":"31","author":"WC Sessa","year":"1994","unstructured":"Sessa, W. C. The Nitric Oxide Synthase Family of Proteins. J. Vas Res. 31, 131\u2013143 (1994).","journal-title":"J. Vas Res."},{"key":"62796_CR8","first-page":"8242","volume":"11","author":"XY Zhang","year":"2007","unstructured":"Zhang, X. Y. & Jia, N. T. Changes of plasma nitric oxide and plasma endothelin-1 levels in hyperhomocysteinemia rats:Verification of endothelial dysfunction. J. Clin. Rehab Tiss. Engin Res. 11, 8242\u20138246 (2007).","journal-title":"J. Clin. Rehab Tiss. Engin Res."},{"key":"62796_CR9","doi-asserted-by":"publisher","first-page":"1186","DOI":"10.1111\/j.1538-7836.2006.01949.x","volume":"4","author":"UM Vischer","year":"2006","unstructured":"Vischer, U. M. von Willebrand factor, endothelial dysfunction, and cardiovascular disease. J. Thromb. Haemo 4, 1186\u20131193 (2006).","journal-title":"J. Thromb. Haemo"},{"key":"62796_CR10","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1089\/105072501300042820","volume":"11","author":"J Burggraaf","year":"2001","unstructured":"Burggraaf, J. et al. Endothelial function in patients with hyperthyroidism before and after treatment with propranolol and thiamazol. Thyroid. 11, 153\u2013160 (2001).","journal-title":"Thyroid."},{"key":"62796_CR11","unstructured":"Xia, M. H., Yin, L. F. & Hematology, D. O. Research progress of endothelial progenitor cells in tumor diseases. J Chin Prac Diag & Ther (2015)."},{"key":"62796_CR12","first-page":"1057","volume":"31","author":"L Liu","year":"2011","unstructured":"Liu, L. & Kang, X. X. Progression of endothelial progenitor cells on vascular repair. Bas Clin. Med. 31, 1057\u20131059 (2011).","journal-title":"Bas Clin. Med."},{"key":"62796_CR13","first-page":"1755","volume":"29","author":"Y Famin","year":"2016","unstructured":"Famin, Y., Rongqing, S., Qingmin, L. & Jingping, L. Influence of hemodynamics on myocardial cell cardiac index and its molecular mechanism. Pak. J. Pharm. Sci. 29, 1755\u20131762 (2016).","journal-title":"Pak. J. Pharm. Sci."},{"key":"62796_CR14","unstructured":"Cui, L. & Cheng, G. The research progress of the effect of nitric oxide in vascular endothelial injury induced by hypothyroidism. Chin Mod Doc. (2017)."},{"key":"62796_CR15","doi-asserted-by":"publisher","first-page":"417","DOI":"10.1160\/TH11-10-0691","volume":"107","author":"RS Kootte","year":"2012","unstructured":"Kootte, R. S. et al. The incidence of venous thromboembolism in patients with overt hyperthyroidism. Thromb. Haem 107, 417\u2013422 (2012).","journal-title":"Thromb. Haem"},{"key":"62796_CR16","unstructured":"Liu, X., Gang, X. U. & Zhang, Q. Study on plasma endothelin(EF-1) level in children with thyroid disease. M & C Heal Care Chin (2005)."},{"key":"62796_CR17","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1179\/2295333714Y.0000000090","volume":"70","author":"V Schamp","year":"2015","unstructured":"Schamp, V. et al. Propylthiouracil induced ANCA-associated vasculitis in a 14-year-old girl. Acta Clin. Belg. 70, 127\u20139, https:\/\/doi.org\/10.1179\/2295333714Y.0000000090 (2015).","journal-title":"Acta Clin. Belg."},{"key":"62796_CR18","doi-asserted-by":"publisher","first-page":"457","DOI":"10.1089\/105072501300176417","volume":"11","author":"P Laurberg","year":"2001","unstructured":"Laurberg, P., B\u00fclow, P. I., Knudsen, N., Ovesen, L. & Andersen, S. Environmental iodine intake affects the type of nonmalignant thyroid disease. Thyroid 11, 457 (2001).","journal-title":"Thyroid"},{"key":"62796_CR19","doi-asserted-by":"publisher","first-page":"2783","DOI":"10.1056\/NEJMoa054022","volume":"354","author":"W Teng","year":"2006","unstructured":"Teng, W. et al. Effect of iodine intake on thyroid diseases in China. N. Engl. J. Med. 354, 2783\u20132793 (2006).","journal-title":"N. Engl. J. Med."},{"key":"62796_CR20","unstructured":"Wang, X. L. et al. Effects on endothelial cell proliferation induced by different concentration of iodine in vitro. J Shandong Univ (2007)."}],"container-title":["Scientific Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41598-020-62796-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-020-62796-0","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-020-62796-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,12,6]],"date-time":"2022-12-06T09:47:59Z","timestamp":1670320079000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41598-020-62796-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,4,24]]},"references-count":20,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2020,12]]}},"alternative-id":["62796"],"URL":"https:\/\/doi.org\/10.1038\/s41598-020-62796-0","relation":{},"ISSN":["2045-2322"],"issn-type":[{"value":"2045-2322","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,4,24]]},"assertion":[{"value":"24 April 2019","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 March 2020","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"24 April 2020","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"6992"}}