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We investigated whether concentrations of selected neurodiagnostic biomarkers in the cerebrospinal fluid of women with preeclampsia\/HELLP syndrome differ from those in healthy controls using enzyme-linked immunosorbent assay technique. We found that <jats:bold>t<\/jats:bold>au protein concentrations (p\u2009=\u20090.016) and phospho-tau\/tau ratio (p\u2009&lt;\u20090.001) in cerebrospinal fluid were significantly lower in 39 preeclamptic women compared to 44 healthy controls during third trimester of pregnancy. Beta-amyloid(1-40)\/(1-42) ratio was significantly higher in HELLP syndrome than in severe preeclampsia (8.49\u2009+\u20092.73 vs. 4.71\u2009+\u20091.65; p\u2009=\u20090.007). We conclude that beta-amyloid(1-40)\/(1-42) ratio in cerebrospinal fluid can discriminate severe preeclampsia and HELLP syndrome. High beta-amyloid peptide and low <jats:bold>t<\/jats:bold>au protein concentrations are associated with impaired development of the materno-feto-placental unit and correlate with placental dysfunction.<\/jats:p>","DOI":"10.1038\/s41598-020-62805-2","type":"journal-article","created":{"date-parts":[[2020,4,1]],"date-time":"2020-04-01T10:03:09Z","timestamp":1585735389000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Cerebrospinal beta-amyloid peptides(1-40) and (1-42) in severe preeclampsia and HELLP syndrome \u2013 a pilot study"],"prefix":"10.1038","volume":"10","author":[{"given":"Wolfgang","family":"Lederer","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Helene","family":"Schaffenrath","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5333-0108","authenticated-orcid":false,"given":"Cristina","family":"Alomar-Dominguez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julia","family":"Thaler","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raffaella","family":"Fantin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lucie","family":"Dostal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guenther","family":"Putz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christian","family":"Humpel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2020,4,1]]},"reference":[{"key":"62805_CR1","doi-asserted-by":"publisher","first-page":"360","DOI":"10.1111\/jmwh.12344","volume":"60","author":"G Latendresse","year":"2015","unstructured":"Latendresse, G. & Founds, S. 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