{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T23:48:44Z","timestamp":1791848924102,"version":"4.3.4"},"reference-count":33,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2020,4,15]],"date-time":"2020-04-15T00:00:00Z","timestamp":1586908800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2020,4,15]],"date-time":"2020-04-15T00:00:00Z","timestamp":1586908800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The prognostic significance of sarcopenia has been widely studied in different cancer patients. This study aimed to analyze the influence of sarcopenia on long-term survival in patients with colorectal liver metastasis (CRLM) undergoing hepatic resection. A retrospective analysis of 182 patients undergoing hepatic resection for CRLM was performed. Sarcopenia was determinedusing the Hounsfield unit average calculation (HUAC), a measure of muscle quality-muscledensity at preoperative abdominal <jats:italic>computed tomography<\/jats:italic> scans. Sarcopenia was defined as an HUAC score of less than 22 HU calculated using receiver operating characteristic analysis. The prognostic relevance of clinical variables and overall survival (OS) and recurrence-free survival (RFS) was evaluated. Patients with sarcopenia were older (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001) and had higher prevalence of diabetics (<jats:italic>p<\/jats:italic>\u2009=\u20090.004), higher body mass index (BMI) (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001) and neutrophil-to-lymphocyte ratio (<jats:italic>p<\/jats:italic>\u2009=\u20090.026) compared to those without. Sarcopenia was not significantly associated with OS and RFS. Multivariate Cox\u2019s regression analysis showed that multinodularity (&gt;3) (hazard ratio (HR) 2.736; 95% confidence interval (CI), 1.631\u20134.589; <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001), high CEA level (\u226520\u2009ng\/ml) (HR 1.793; 95% CI, 1.092\u20132.945; <jats:italic>p<\/jats:italic>\u2009=\u20090.021) and blood loss (\u2265300 cc) (HR1.793; 95% CI, 1.084\u20132.964; <jats:italic>p<\/jats:italic>\u2009=\u20090.023) were independent factors associated with OS. In subgroup analyses, sarcopenia was a significant factor of poor OS in the patients with multinodularity by univariate (<jats:italic>p<\/jats:italic>\u2009=\u20090.002) and multivariate analyses(HR 3.571; 95% CI, 1.508\u20138.403; <jats:italic>p<\/jats:italic>\u2009=\u20090.004). Multinodularity (&gt;3) (HR 1.750; 95% CI, 1.066\u20132.872; <jats:italic>p<\/jats:italic>\u2009=\u20090.027), high aspartate aminotransferase level (HR 1.024; 95% CI, 1.003\u20131.046; <jats:italic>p<\/jats:italic>\u2009=\u20090.025) and male gender (HR 1.688; 95% CI, 1.036\u20132.748; <jats:italic>p<\/jats:italic>\u2009=\u20090.035) were independent factors of RFS. In conclusion, despite no significance in whole cohort, sarcopenia was predictive of worse OS in patients with multiple CRLM after partial hepatectomy.<\/jats:p>","DOI":"10.1038\/s41598-020-63644-x","type":"journal-article","created":{"date-parts":[[2020,4,15]],"date-time":"2020-04-15T10:03:27Z","timestamp":1586945007000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Prognostic value of sarcopenia in patients with colorectal liver metastases undergoing hepatic resection"],"prefix":"10.1038","volume":"10","author":[{"given":"Yueh-Wei","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chien-Chang","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ching-Di","family":"Chang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ko-Chao","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong Hwa","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen Shuo","family":"Yeh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wang-Hseng","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kai-Lung","family":"Tsai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheng-Hsi","family":"Yeh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sin-Yong","family":"Wee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shin-Min","family":"Yin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chih-Chi","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1646-9519","authenticated-orcid":false,"given":"Chao-Hung","family":"Hung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2020,4,15]]},"reference":[{"key":"63644_CR1","doi-asserted-by":"publisher","first-page":"66","DOI":"10.1159\/000449348","volume":"6","author":"RP Jones","year":"2016","unstructured":"Jones, R. 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