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Most mammalian species are infectable by\n                    <jats:italic>Leptospira<\/jats:italic>\n                    but only few act as efficient reservoir being capable of establishing long term kidney colonization and shedding\n                    <jats:italic>Leptospira<\/jats:italic>\n                    in urine. In Madagascar, a large diversity of pathogenic\n                    <jats:italic>Leptospira<\/jats:italic>\n                    display a tight specificity towards their endemic volant or terrestrial mammalian hosts. The basis of this specificity is unknown: it may indicate some genetically determined compatibility between host cells and bacteria or only reflect ecological constraints preventing contacts between specific hosts. In this study,\n                    <jats:italic>Rattus norvegicus<\/jats:italic>\n                    was experimentally infected with either\n                    <jats:italic>Leptospira interrogans, Leptospira borgpetersenii<\/jats:italic>\n                    or\n                    <jats:italic>Leptospira mayottensis<\/jats:italic>\n                    isolated from rats, bats or tenrecs, respectively.\n                    <jats:italic>Leptospira borgpetersenii<\/jats:italic>\n                    and\n                    <jats:italic>L. mayottensis<\/jats:italic>\n                    do not support renal colonization as featured by no shedding of live bacteria in urine and low level and sporadic detection of\n                    <jats:italic>Leptospira<\/jats:italic>\n                    DNA in kidneys. In contrast 2 out of the 7\n                    <jats:italic>\u2009R. norvegicus<\/jats:italic>\n                    challenged with\n                    <jats:italic>L. interrogans<\/jats:italic>\n                    developed renal colonization and intense\n                    <jats:italic>Leptospira<\/jats:italic>\n                    shedding in urine throughout the 3 months of experimental infection. These data suggest that host-\n                    <jats:italic>Leptospira<\/jats:italic>\n                    specificity in this biodiversity hotspot is driven at least in part by genetic determinants likely resulting from long-term co-diversification processes.\n                  <\/jats:p>","DOI":"10.1038\/s41598-020-64172-4","type":"journal-article","created":{"date-parts":[[2020,4,29]],"date-time":"2020-04-29T06:03:17Z","timestamp":1588140197000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":54,"title":["Pathogenic Leptospira and their animal reservoirs: testing host specificity through experimental infection"],"prefix":"10.1038","volume":"10","author":[{"given":"Colette","family":"Cordonin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Magali","family":"Turpin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthieu","family":"Bringart","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Loup","family":"Bascands","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1416-0449","authenticated-orcid":false,"given":"Olivier","family":"Flores","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koussay","family":"Dellagi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick","family":"Mavingui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marjolaine","family":"Roche","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7928-7264","authenticated-orcid":false,"given":"Pablo","family":"Tortosa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2020,4,29]]},"reference":[{"key":"64172_CR1","first-page":"1","volume":"387","author":"B Adler","year":"2015","unstructured":"Adler, B. 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