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In this proof-of-concept, prospective non-randomized study carried out in a single academic healthcare centre, we examined whether replacing CO<jats:sub>Fick<\/jats:sub> in the Gorlin formula with Cheetah-NICOM monitor cardiac output (CO<jats:sub>Cheetah<\/jats:sub>) could produce an accurate and precise estimate of aortic valve area in patients with severe aortic stenosis. In twenty-six subjects, CO<jats:sub>Fick<\/jats:sub> and CO<jats:sub>Cheetah<\/jats:sub> were obtained concurrently. A spot and 3-minute running average of CO<jats:sub>Cheetah<\/jats:sub> was used. Bland and Altman analysis was used to derive bias, 95% limits of agreement (LOA) and confidence intervals (CI). The mean difference (bias) between AVA<jats:sub>Cheetah<\/jats:sub> (average) and AVA<jats:sub>Fick<\/jats:sub> was 0.11 cm<jats:sup>2<\/jats:sup> and the 95% LOA were \u00b10.42 cm<jats:sup>2<\/jats:sup>. The 95% CI of the bias was 0.02\u20130.2 cm<jats:sup>2<\/jats:sup>. The bias and 95% LOA of AVA<jats:sub>Cheetah<\/jats:sub> (spot value) were 0.14\u2009\u00b1\u20090.42cm<jats:sup>2<\/jats:sup>, with a 95% CI of 0.06\u20130.23 cm<jats:sup>2<\/jats:sup>. No proportional bias was present. AVA<jats:sub>Cheetah<\/jats:sub> thus appears to be a reasonably accurate measure of AVA in patients with severe aortic stenosis compared to AVA<jats:sub>Fick<\/jats:sub> measured using a modified Fick CO. However, the limits of agreement were not narrow enough to consider AVA<jats:sub>Cheetah<\/jats:sub> and AVA<jats:sub>Fick<\/jats:sub> interchangeable.<\/jats:p>","DOI":"10.1038\/s41598-020-64753-3","type":"journal-article","created":{"date-parts":[[2020,5,12]],"date-time":"2020-05-12T10:05:02Z","timestamp":1589277902000},"update-policy":"http:\/\/dx.doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["A Pilot Study Comparing Aortic Valve Area Estimates Derived from Fick Cardiac Output with Estimates Based on Cheetah-NICOM Cardiac Output"],"prefix":"10.1038","volume":"10","author":[{"given":"Ludmil","family":"Mitrev","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Noud","family":"van Helmond","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Georges","family":"Kaddissi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ahmed","family":"Awad","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kinjal","family":"Patel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Janah","family":"Aji","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeffrey","family":"Ogbara","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zahi","family":"Rafeq","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vineeth","family":"Nagubandi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Debbie","family":"Orr","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John","family":"Gaughan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Rosenbloom","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2020,5,12]]},"reference":[{"key":"64753_CR1","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/0002-8703(51)90002-6","volume":"41","author":"R Gorlin","year":"1951","unstructured":"Gorlin, R. & Gorlin, S. 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