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In this study, we demonstrate that a butyric acid-producing\n                    <jats:italic>Leuconostoc mesenteroides<\/jats:italic>\n                    (\n                    <jats:italic>L. mesenteroides<\/jats:italic>\n                    ) EH-1 strain isolated from Mongolian curd cheese can reduce blood glucose and IL-6 in the type 1 diabetic mouse model.\n                    <jats:italic>L. mesenteroides<\/jats:italic>\n                    EH-1 fermentation yielded high concentrations of butyric acid both\n                    <jats:italic>in vitro<\/jats:italic>\n                    and\n                    <jats:italic>in vivo<\/jats:italic>\n                    . Butyric acid or\n                    <jats:italic>L. mesenteroides<\/jats:italic>\n                    EH-1 increased the amounts of insulin in Min6 cell culture and streptozotocin (STZ)-induced diabetic mice. Inhibition or siRNA knockdown of free fatty acid receptor 2 (Ffar2) considerably reduced the anti-diabetic effect of probiotic\n                    <jats:italic>L. mesenteroides<\/jats:italic>\n                    EH-1 or butyric acid by lowering the level of blood glucose. We here demonstrate that Ffar2 mediated the effects of\n                    <jats:italic>L. mesenteroides<\/jats:italic>\n                    EH-1 and butryic acid on regulation of blood glucose and insulin in type 1 diabetic mice.\n                  <\/jats:p>","DOI":"10.1038\/s41598-020-64916-2","type":"journal-article","created":{"date-parts":[[2020,5,13]],"date-time":"2020-05-13T06:02:50Z","timestamp":1589349770000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":60,"title":["Leuconostoc mesenteroides fermentation produces butyric acid and mediates Ffar2 to regulate blood glucose and insulin in type 1 diabetic mice"],"prefix":"10.1038","volume":"10","author":[{"given":"Supitchaya","family":"Traisaeng","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anir","family":"Batsukh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tsung-Hsien","family":"Chuang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deron Raymond","family":"Herr","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu-Fen","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Battogtokh","family":"Chimeddorj","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chun-Ming","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2020,5,13]]},"reference":[{"key":"64916_CR1","first-page":"415","volume":"1","author":"S Warren","year":"1925","unstructured":"Warren, S. & Root, H. 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