{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,8,5]],"date-time":"2024-08-05T22:41:33Z","timestamp":1722897693579},"reference-count":19,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2020,5,15]],"date-time":"2020-05-15T00:00:00Z","timestamp":1589500800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2020,5,15]],"date-time":"2020-05-15T00:00:00Z","timestamp":1589500800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"abstract":"<jats:title>Abstract<\/jats:title><jats:p>We examined human exposures to dental products (EDP), stomatological preparations (ESP), and in the context of dental care (EDC) or toothache (ETA) registered by the Poisons Information Centre (PIC) Erfurt from 1997 to 2017. Dental products like dental technical and filling materials belong to medical devices. Stomatological preparations were classified according to the ATC code and symptom severity to the Poisoning Severity Score (PSS). In total, 156 cases of EDP (136 cases with different tooth filling materials), 1167 cases of ESP (55.6% fluoride containing products), 979 cases of EDC, and 331 cases of ETA were registered. Symptom severity in EDP and ESP were asymptomatic or mild. In ETA and EDC, however, 35 cases with moderate and 5 cases with severe symptoms were detected. 5 moderate and 3 severe cases were caused by prolonged paracetamol overdose. Severe bleeding occurred following tooth extraction in a 41 year-old phenprocoumon treated patient after self-medication with acetylsalicylic acid and metamizole. Gingival injection of lidocaine plus epinephrine in a 37 year-old healthy woman resulted in severe bradycardia and cardiac arrest. Acute toxicity of EDP and ESP appears to be low. Prolonged paracetamol overdose because of toothache, and some dental treatment can result in severe symptoms.<\/jats:p>","DOI":"10.1038\/s41598-020-65079-w","type":"journal-article","created":{"date-parts":[[2020,5,15]],"date-time":"2020-05-15T10:21:14Z","timestamp":1589538074000},"update-policy":"http:\/\/dx.doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Exposures to Dental Products, Stomatological Preparations, and in Dental Care and Toothache reported to the PIC Erfurt (1997 to 2017)"],"prefix":"10.1038","volume":"10","author":[{"given":"Beate","family":"Budenz","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Deters","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dagmar","family":"Prasa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Helmut","family":"Hentschel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2020,5,15]]},"reference":[{"key":"65079_CR1","unstructured":"Al-Nawas, B. et al. Das Dental Vademecum. 10. Ausgabe 2009\/2010 Bundeszahn\u00e4rztekammer. Kassenzahn\u00e4rztliche Bundesvereinigung. Deutscher Zahn\u00e4rzteverlag, https:\/\/www.bzaek.de\/fileadmin\/PDFs\/za\/AKZ\/DDV10.pdf (2009)."},{"key":"65079_CR2","unstructured":"Ge\u00dfner, F., R\u00f6mer, G., Antwerpes, F. & Ostendorf, N. Stomatologikum. DocCheck Flexicon, https:\/\/flexikon.doccheck.com\/de\/Stomatologikum#Weblinks (2018)."},{"key":"65079_CR3","unstructured":"Pfeffer, H. et al. Informationen \u00fcber Zahn\u00e4rztliche Arzneimittel (IZA). Arzneimittel-kommission Zahn\u00e4rzte 01\/2019, https:\/\/www.bzaek.de\/fileadmin\/PDFs\/iza_pdf\/IZA.pdf (2019)."},{"key":"65079_CR4","unstructured":"WHO Collaborating Centre for Drug Statistics Methodology. The Anatomical Therapeutic Chemical (ATC) classification system, https:\/\/www.whocc.no\/ (2019)."},{"key":"65079_CR5","first-page":"205","volume":"36","author":"HE Persson","year":"1998","unstructured":"Persson, H. E., Sj\u00f6berg, G. K., Haines, J. A. & Pronczuk de Garbino, J. Poisoning Severity Score. Grading of acute poisoning. Clin. Toxicol. 36, 205\u2013213 (1998).","journal-title":"Clin. Toxicol."},{"key":"65079_CR6","unstructured":"Sachs, L. & Hedderich, J. Angewandte Statistik: Konfidenzintervalle. 12th edn. 256 (Springer-Verlag, 2006)."},{"key":"65079_CR7","unstructured":"Bundesinstitut f\u00fcr Arzneimittel und Medizinprodukte. Amalgame in der zahn\u00e4rztlichen Therapie. Eine Informationsschrift des Bundesinstituts f\u00fcr Arzneimittel und Medizinprodukte Stand der Information: Januar 2005, http:\/\/www.agz-rnk.de\/agz\/download\/3\/broschuere_amalgame.pdf (2005)."},{"key":"65079_CR8","unstructured":"Bundeszahn\u00e4rztekammer. Position EU-Quecksilberverordnung Verordnung (EU) 2017\/852, https:\/\/www.bzaek.de\/fileadmin\/PDFs\/b\/Position_Amalgam.pdf (2018)."},{"key":"65079_CR9","unstructured":"Reichel, F., Mohr, K., Hein, L. & Hickel, R. Atlas der Pharmakologie und Toxikologie f\u00fcr Zahnmediziner. 2nd edn. 324-327 (Thieme-Verlag, 2014)."},{"key":"65079_CR10","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1007\/s00101-004-0733-x","volume":"54","author":"H Richter","year":"2005","unstructured":"Richter, H., Hollenberg, S., Sachs, H. J., Oeltjenbruns, J. & Weimann, J. Ver\u00e4tzung mit Flusss\u00e4ure. Anaesthesist 54, 123\u2013126 (2005).","journal-title":"Anaesthesist"},{"key":"65079_CR11","unstructured":"Hellwig, E., Klimek, J. & Attin, T. Einf\u00fchrung in die Zahnerhaltung. 5th edn. 140-142 (Deutscher Zahn\u00e4rzte Verlag, 2009)."},{"key":"65079_CR12","doi-asserted-by":"crossref","unstructured":"Falbe, J. & Regitz, M. R\u00f6mpp Lexikon Chemie. 10th edn. (eds. Falbe J., & Regitz, M.) 46 (Thieme-Verlag, 1996\u20131999).","DOI":"10.1055\/b-004-134467"},{"key":"65079_CR13","doi-asserted-by":"crossref","unstructured":"M\u00fchlendahl, K. E., Oberdisse, U., Bunjes, R. & Brockstedt, M. Vergiftungen im Kindesalter. 4th edn. 69, 164, 311, 408 (Thieme-Verlag, 2003).","DOI":"10.1055\/b-002-54088"},{"key":"65079_CR14","unstructured":"Product Information: lidocaine, 5% topical ointment. E. Fougera & Co (per DailyMed), https:\/\/dailymed.nlm.nih.gov\/dailymed\/drugInfo.cfm?setid=88ca9cba-0c4a-482f-b502-ceefdb1bfbcd#s27 (2018)."},{"key":"65079_CR15","unstructured":"FDA: Lidocain in \u201eZahnungshilfen\u201c bergen t\u00f6dliche Risiken. aerzteblatt.de, 27 June 2014, https:\/\/www.aerzteblatt.de\/nachrichten\/59196\/FDA-Lidocain-in-Zahnungshilfen-bergen-toedliche-Risiken (2014)."},{"key":"65079_CR16","doi-asserted-by":"publisher","first-page":"783","DOI":"10.1097\/PRS.0000000000005989","volume":"144","author":"M Gitman","year":"2019","unstructured":"Gitman, M., Fettiplace, M. R., Weinberg, G., Neal, J. M. & Barrington, M. J. Local Anesthetic Systemic Toxicity: A Narrative Literature Review and Clinical Update on Prevention, Diagnosis and Management. Plast. Reconstr. Surg. 144, 783\u2013795 (2019).","journal-title":"Plast. Reconstr. Surg."},{"key":"65079_CR17","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1055\/s-0035-1555944","volume":"78","author":"H Hentschel","year":"2016","unstructured":"Hentschel, H. et al. Single Drug Exposures to Non-opioid Analgesics Reported to the Poisons Information Centre Erfurt from 2003 to 2012. Gesundheitswesen 78, 14\u201321 (2016).","journal-title":"Gesundheitswesen"},{"key":"65079_CR18","doi-asserted-by":"crossref","unstructured":"B\u00f6ger, R. H. & Schmidt, G. Antirheumatika und Antiphlogistika. In Arzneiverordnungsreport 2018 (eds. Schwabe, U., Paffrath, D. & Klauber L.) 423\u2013434 (Springer- Verlag, 2018).","DOI":"10.1007\/978-3-662-57386-0_19"},{"key":"65079_CR19","doi-asserted-by":"crossref","unstructured":"Halling, F. Zahn\u00e4rztliche Arzneiverordnungen. In Arzneiverordnungsreport 2018 (eds. U. Schwabe, U., Paffrath, D. & Klauber L.) 813\u2013824 (Springer- Verlag, 2018).","DOI":"10.1007\/978-3-662-57386-0_47"}],"container-title":["Scientific Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41598-020-65079-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-020-65079-w","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-020-65079-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,5]],"date-time":"2024-08-05T21:35:56Z","timestamp":1722893756000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41598-020-65079-w"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,5,15]]},"references-count":19,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2020,12]]}},"alternative-id":["65079"],"URL":"https:\/\/doi.org\/10.1038\/s41598-020-65079-w","relation":{},"ISSN":["2045-2322"],"issn-type":[{"type":"electronic","value":"2045-2322"}],"subject":[],"published":{"date-parts":[[2020,5,15]]},"assertion":[{"value":"7 January 2020","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"27 April 2020","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"15 May 2020","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"8057"}}