{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,5]],"date-time":"2026-11-05T03:20:59Z","timestamp":1793848859868,"version":"4.6.1"},"reference-count":55,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2020,5,29]],"date-time":"2020-05-29T00:00:00Z","timestamp":1590710400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2020,5,29]],"date-time":"2020-05-29T00:00:00Z","timestamp":1590710400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Thermal homeostasis in mammalians is a self-regulating process by which biological systems maintain an internal thermal stability, even under different temperature conditions; however, the molecular mechanisms involved under warm ambient temperature remain unclear. Here, we aimed to clarify functional significance of transient receptor potential vanilloid receptor 1 (TRPV1) under warm ambient temperature. TRPV1 KO mice exhibited transient hyperthermia when exposed to 30.0 and 32.5\u2009\u00b0C, whereas wild-type (WT) mice did not. TRPV1 KO mice exhibited prolonged and prominent hyperthermia upon exposure to 35.0\u2009\u00b0C, whereas WT mice showed transient hyperthermia. Hyperthermia also occurs in WT mice that received intracerebroventricular injection of TRPV1 antagonist AMG9810 upon exposure to 35.0\u2009\u00b0C. Heat loss behaviors, sleeping and body licking, were deficient in TRPV1 KO mice exposed to warm temperatures. Therefore, the present results indicate that central TRPV1 is crucial for maintaining a constant body temperature via the initiation of heat loss behaviors under warm ambient temperature.<\/jats:p>","DOI":"10.1038\/s41598-020-65703-9","type":"journal-article","created":{"date-parts":[[2020,5,29]],"date-time":"2020-05-29T10:02:27Z","timestamp":1590746547000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":34,"title":["TRPV1 is crucial for thermal homeostasis in the mouse by heat loss behaviors under warm ambient temperature"],"prefix":"10.1038","volume":"10","author":[{"given":"Park","family":"Yonghak","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seiji","family":"Miyata","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erkin","family":"Kurganov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2020,5,29]]},"reference":[{"key":"65703_CR1","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1152\/advan.00126.2014","volume":"39","author":"EA Tansey","year":"2015","unstructured":"Tansey, E. A. & Johnson, C. D. Recent advances in thermoregulation. Adv Physiol Educ 39, 139\u2013148, https:\/\/doi.org\/10.1152\/advan.00126.2014 (2015).","journal-title":"Adv Physiol Educ"},{"key":"65703_CR2","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1016\/j.neuron.2018.02.022","volume":"98","author":"CL Tan","year":"2018","unstructured":"Tan, C. L. & Knight, Z. A. Regulation of Body Temperature by the Nervous System. Neuron 98, 31\u201348, https:\/\/doi.org\/10.1016\/j.neuron.2018.02.022 (2018).","journal-title":"Neuron"},{"key":"65703_CR3","doi-asserted-by":"publisher","first-page":"639","DOI":"10.1146\/annurev.ph.48.030186.003231","volume":"48","author":"JA Boulant","year":"1986","unstructured":"Boulant, J. A. & Dean, J. B. Temperature receptors in the central nervous system. Annu Rev Physiol 48, 639\u2013654, https:\/\/doi.org\/10.1146\/annurev.ph.48.030186.003231 (1986).","journal-title":"Annu Rev Physiol"},{"key":"65703_CR4","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1007\/s00421-009-1216-1","volume":"109","author":"J Werner","year":"2010","unstructured":"Werner, J. System properties, feedback control and effector coordination of human temperature regulation. Eur J Appl Physiol 109, 13\u201325, https:\/\/doi.org\/10.1007\/s00421-009-1216-1 (2010).","journal-title":"Eur J Appl Physiol"},{"key":"65703_CR5","doi-asserted-by":"publisher","first-page":"R992","DOI":"10.1152\/ajpregu.00068.2004","volume":"287","author":"AA Romanovsky","year":"2004","unstructured":"Romanovsky, A. A. Do fever and anapyrexia exist? Analysis of set point-based definitions. Am J Physiol Regul Integr Comp Physiol 287, R992\u2013995, https:\/\/doi.org\/10.1152\/ajpregu.00068.2004 (2004).","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"key":"65703_CR6","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1007\/s00421-009-1256-6","volume":"109","author":"K Kanosue","year":"2010","unstructured":"Kanosue, K., Crawshaw, L. I., Nagashima, K. & Yoda, T. Concepts to utilize in describing thermoregulation and neurophysiological evidence for how the system works. Eur J Appl Physiol 109, 5\u201311, https:\/\/doi.org\/10.1007\/s00421-009-1256-6 (2010).","journal-title":"Eur J Appl Physiol"},{"key":"65703_CR7","doi-asserted-by":"publisher","first-page":"225","DOI":"10.1016\/j.neulet.2018.11.027","volume":"696","author":"CJ Madden","year":"2019","unstructured":"Madden, C. J. & Morrison, S. F. Central nervous system circuits that control body temperature. Neurosci Lett 696, 225\u2013232, https:\/\/doi.org\/10.1016\/j.neulet.2018.11.027 (2019).","journal-title":"Neurosci Lett"},{"key":"65703_CR8","doi-asserted-by":"publisher","first-page":"494","DOI":"10.1152\/ajplegacy.1969.217.2.494","volume":"217","author":"FR Hainsworth","year":"1969","unstructured":"Hainsworth, F. R. & Stricker, E. M. Evaporative cooling in the rat: effects of partial desalivation. Am J Physiol 217, 494\u2013497, https:\/\/doi.org\/10.1152\/ajplegacy.1969.217.2.494 (1969).","journal-title":"Am J Physiol"},{"key":"65703_CR9","doi-asserted-by":"publisher","first-page":"1428","DOI":"10.2741\/3797","volume":"16","author":"J Terrien","year":"2011","unstructured":"Terrien, J., Perret, M. & Aujard, F. Behavioral thermoregulation in mammals: a review. Front Biosci (Landmark Ed) 16, 1428\u20131444, https:\/\/doi.org\/10.2741\/3797 (2011).","journal-title":"Front Biosci (Landmark Ed)"},{"key":"65703_CR10","doi-asserted-by":"publisher","first-page":"591","DOI":"10.1124\/pr.55.4.6","volume":"55","author":"DE Clapham","year":"2003","unstructured":"Clapham, D. E., Montell, C., Schultz, G. & Julius, D. & International Union of, P. International Union of Pharmacology. XLIII. Compendium of voltage-gated ion channels: transient receptor potential channels. Pharmacol Rev 55, 591\u2013596, https:\/\/doi.org\/10.1124\/pr.55.4.6 (2003).","journal-title":"Pharmacol Rev"},{"key":"65703_CR11","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1038\/s41422-018-0129-0","volume":"29","author":"X Liu","year":"2019","unstructured":"Liu, X. et al. STIM1 thermosensitivity defines the optimal preference temperature for warm sensation in mice. Cell Res 29, 95\u2013109, https:\/\/doi.org\/10.1038\/s41422-018-0129-0 (2019).","journal-title":"Cell Res"},{"key":"65703_CR12","doi-asserted-by":"publisher","first-page":"816","DOI":"10.1038\/39807","volume":"389","author":"MJ Caterina","year":"1997","unstructured":"Caterina, M. J. et al. The capsaicin receptor: a heat-activated ion channel in the pain pathway. Nature 389, 816\u2013824, https:\/\/doi.org\/10.1038\/39807 (1997).","journal-title":"Nature"},{"key":"65703_CR13","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1523\/JNEUROSCI.4901-08.2009","volume":"29","author":"A Dhaka","year":"2009","unstructured":"Dhaka, A. et al. TRPV1 is activated by both acidic and basic pH. J Neurosci 29, 153\u2013158, https:\/\/doi.org\/10.1523\/JNEUROSCI.4901-08.2009 (2009).","journal-title":"J Neurosci"},{"key":"65703_CR14","doi-asserted-by":"publisher","first-page":"790","DOI":"10.1038\/sj.bjp.0705467","volume":"140","author":"RA Ross","year":"2003","unstructured":"Ross, R. A. Anandamide and vanilloid TRPV1 receptors. Br J Pharmacol 140, 790\u2013801, https:\/\/doi.org\/10.1038\/sj.bjp.0705467 (2003).","journal-title":"Br J Pharmacol"},{"key":"65703_CR15","doi-asserted-by":"publisher","first-page":"1421","DOI":"10.1111\/j.1460-9568.2004.03221.x","volume":"19","author":"Z Szelenyi","year":"2004","unstructured":"Szelenyi, Z., Hummel, Z., Szolcsanyi, J. & Davis, J. B. Daily body temperature rhythm and heat tolerance in TRPV1 knockout and capsaicin pretreated mice. Eur J Neurosci 19, 1421\u20131424, https:\/\/doi.org\/10.1111\/j.1460-9568.2004.03221.x (2004).","journal-title":"Eur J Neurosci"},{"key":"65703_CR16","doi-asserted-by":"publisher","first-page":"7459","DOI":"10.1523\/JNEUROSCI.1483-07.2007","volume":"27","author":"AA Steiner","year":"2007","unstructured":"Steiner, A. A. et al. Nonthermal activation of transient receptor potential vanilloid-1 channels in abdominal viscera tonically inhibits autonomic cold-defense effectors. J Neurosci 27, 7459\u20137468, https:\/\/doi.org\/10.1523\/JNEUROSCI.1483-07.2007 (2007).","journal-title":"J Neurosci"},{"key":"65703_CR17","doi-asserted-by":"publisher","first-page":"474","DOI":"10.1124\/jpet.104.079855","volume":"313","author":"NR Gavva","year":"2005","unstructured":"Gavva, N. R. et al. AMG 9810 [(E)-3-(4-t-butylphenyl)-N-(2,3-dihydrobenzo[b][1,4] dioxin-6-yl)acrylamide], a novel vanilloid receptor 1 (TRPV1) antagonist with antihyperalgesic properties. J Pharmacol Exp Ther 313, 474\u2013484, https:\/\/doi.org\/10.1124\/jpet.104.079855 (2005).","journal-title":"J Pharmacol Exp Ther"},{"key":"65703_CR18","doi-asserted-by":"publisher","first-page":"228","DOI":"10.1124\/pr.109.001263","volume":"61","author":"AA Romanovsky","year":"2009","unstructured":"Romanovsky, A. A. et al. The transient receptor potential vanilloid-1 channel in thermoregulation: a thermosensor it is not. Pharmacol Rev 61, 228\u2013261, https:\/\/doi.org\/10.1124\/pr.109.001263 (2009).","journal-title":"Pharmacol Rev"},{"key":"65703_CR19","doi-asserted-by":"publisher","DOI":"10.1038\/srep26088","volume":"6","author":"A Yoshida","year":"2016","unstructured":"Yoshida, A. et al. TRPV1 is crucial for proinflammatory STAT3 signaling and thermoregulation-associated pathways in the brain during inflammation. Sci Rep 6, 26088, https:\/\/doi.org\/10.1038\/srep26088 (2016).","journal-title":"Sci Rep"},{"key":"65703_CR20","doi-asserted-by":"publisher","first-page":"58","DOI":"10.1016\/j.brainres.2009.02.018","volume":"1268","author":"S McGaraughty","year":"2009","unstructured":"McGaraughty, S. et al. Antagonism of TRPV1 receptors indirectly modulates activity of thermoregulatory neurons in the medial preoptic area of rats. Brain Res 1268, 58\u201367, https:\/\/doi.org\/10.1016\/j.brainres.2009.02.018 (2009).","journal-title":"Brain Res"},{"key":"65703_CR21","doi-asserted-by":"publisher","first-page":"306","DOI":"10.1126\/science.288.5464.306","volume":"288","author":"MJ Caterina","year":"2000","unstructured":"Caterina, M. J. et al. Impaired nociception and pain sensation in mice lacking the capsaicin receptor. Science 288, 306\u2013313 (2000).","journal-title":"Science"},{"key":"65703_CR22","doi-asserted-by":"publisher","first-page":"5533","DOI":"10.1523\/JNEUROSCI.5788-12.2013","volume":"33","author":"LA Pogorzala","year":"2013","unstructured":"Pogorzala, L. A., Mishra, S. K. & Hoon, M. A. The cellular code for mammalian thermosensation. J Neurosci 33, 5533\u20135541, https:\/\/doi.org\/10.1523\/JNEUROSCI.5788-12.2013 (2013).","journal-title":"J Neurosci"},{"key":"65703_CR23","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2020.02.035","author":"R Paricio-Montesinos","year":"2020","unstructured":"Paricio-Montesinos, R. et al. The Sensory Coding of Warm Perception. Neuron https:\/\/doi.org\/10.1016\/j.neuron.2020.02.035 (2020).","journal-title":"Neuron"},{"key":"65703_CR24","unstructured":"Guyton, A. C. Textbook of medical physiology. 8th edn, (Saunders, 1991)."},{"key":"65703_CR25","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1007\/bf00635627","volume":"62","author":"GA Meijer","year":"1991","unstructured":"Meijer, G. A. et al. Body composition and sleeping metabolic rate in response to a 5-month endurance-training programme in adults. Eur J Appl Physiol Occup Physiol 62, 18\u201321, https:\/\/doi.org\/10.1007\/bf00635627 (1991).","journal-title":"Eur J Appl Physiol Occup Physiol"},{"key":"65703_CR26","doi-asserted-by":"publisher","first-page":"1721","DOI":"10.1523\/JNEUROSCI.4671-10.2011","volume":"31","author":"A Garami","year":"2011","unstructured":"Garami, A. et al. Thermoregulatory phenotype of the Trpv1 knockout mouse: thermoeffector dysbalance with hyperkinesis. J Neurosci 31, 1721\u20131733, https:\/\/doi.org\/10.1523\/JNEUROSCI.4671-10.2011 (2011).","journal-title":"J Neurosci"},{"key":"65703_CR27","doi-asserted-by":"publisher","first-page":"128","DOI":"10.1124\/jpet.107.125674","volume":"323","author":"NR Gavva","year":"2007","unstructured":"Gavva, N. R. et al. Repeated administration of vanilloid receptor TRPV1 antagonists attenuates hyperthermia elicited by TRPV1 blockade. J Pharmacol Exp Ther 323, 128\u2013137, https:\/\/doi.org\/10.1124\/jpet.107.125674 (2007).","journal-title":"J Pharmacol Exp Ther"},{"key":"65703_CR28","doi-asserted-by":"publisher","first-page":"213","DOI":"10.1016\/j.physbeh.2019.04.015","volume":"206","author":"H Inagaki","year":"2019","unstructured":"Inagaki, H., Kurganov, E., Park, Y., Furube, E. & Miyata, S. Oral gavage of capsaicin causes TRPV1-dependent acute hypothermia and TRPV1-independent long-lasting increase of locomotor activity in the mouse. Physiol Behav 206, 213\u2013224, https:\/\/doi.org\/10.1016\/j.physbeh.2019.04.015 (2019).","journal-title":"Physiol Behav"},{"key":"65703_CR29","doi-asserted-by":"publisher","first-page":"495","DOI":"10.1113\/jphysiol.1970.sp009027","volume":"206","author":"A Jancso-Gabor","year":"1970","unstructured":"Jancso-Gabor, A., Szolcsanyi, J. & Jancso, N. Irreversible impairment of thermoregulation induced by capsaicin and similar pungent substances in rats and guinea-pigs. J Physiol 206, 495\u2013507 (1970).","journal-title":"J Physiol"},{"key":"65703_CR30","doi-asserted-by":"publisher","first-page":"389","DOI":"10.1016\/0163-7258(84)90041-X","volume":"26","author":"T Hori","year":"1984","unstructured":"Hori, T. Capsaicin and central control of thermoregulation. Pharmacol Ther 26, 389\u2013416 (1984).","journal-title":"Pharmacol Ther"},{"key":"65703_CR31","doi-asserted-by":"publisher","first-page":"1288","DOI":"10.1152\/ajplegacy.1967.212.6.1288","volume":"212","author":"FR Hainsworth","year":"1967","unstructured":"Hainsworth, F. R. Saliva spreading, activity, and body temperature regulation in the rat. Am J Physiol 212, 1288\u20131292, https:\/\/doi.org\/10.1152\/ajplegacy.1967.212.6.1288 (1967).","journal-title":"Am J Physiol"},{"key":"65703_CR32","doi-asserted-by":"publisher","first-page":"573","DOI":"10.1139\/y71-074","volume":"49","author":"FR Hainsworth","year":"1971","unstructured":"Hainsworth, F. R. & Stricker, E. M. Evaporative cooling in the rat: differences between salivary glands as thermoregulatory effectors. Can J Physiol Pharmacol 49, 573\u2013580, https:\/\/doi.org\/10.1139\/y71-074 (1971).","journal-title":"Can J Physiol Pharmacol"},{"key":"65703_CR33","doi-asserted-by":"publisher","first-page":"585","DOI":"10.1113\/jphysiol.1991.sp018402","volume":"432","author":"M Yanase","year":"1991","unstructured":"Yanase, M., Kanosue, K., Yasuda, H. & Tanaka, H. Salivary secretion and grooming behaviour during heat exposure in freely moving rats. J Physiol 432, 585\u2013592, https:\/\/doi.org\/10.1113\/jphysiol.1991.sp018402 (1991).","journal-title":"J Physiol"},{"key":"65703_CR34","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1016\/0031-9384(86)90145-9","volume":"38","author":"H Tanaka","year":"1986","unstructured":"Tanaka, H., Kanosue, K., Nakayama, T. & Shen, Z. Grooming, body extension, and vasomotor responses induced by hypothalamic warming at different ambient temperatures in rats. Physiol Behav 38, 145\u2013151, https:\/\/doi.org\/10.1016\/0031-9384(86)90145-9 (1986).","journal-title":"Physiol Behav"},{"key":"65703_CR35","doi-asserted-by":"publisher","first-page":"984","DOI":"10.1111\/ejn.12463","volume":"39","author":"E Szentirmai","year":"2014","unstructured":"Szentirmai, E. & Kapas, L. Intact brown adipose tissue thermogenesis is required for restorative sleep responses after sleep loss. Eur J Neurosci 39, 984\u2013998, https:\/\/doi.org\/10.1111\/ejn.12463 (2014).","journal-title":"Eur J Neurosci"},{"key":"65703_CR36","doi-asserted-by":"publisher","first-page":"2263","DOI":"10.1016\/j.cub.2018.05.054","volume":"28","author":"EC Harding","year":"2018","unstructured":"Harding, E. C. et al. A Neuronal Hub Binding Sleep Initiation and Body Cooling in Response to a Warm External Stimulus. Curr Biol 28, 2263\u20132273 e2264, https:\/\/doi.org\/10.1016\/j.cub.2018.05.054 (2018).","journal-title":"Curr Biol"},{"key":"65703_CR37","doi-asserted-by":"publisher","first-page":"277","DOI":"10.1080\/23328940.2015.1048928","volume":"2","author":"J Szolcsanyi","year":"2015","unstructured":"Szolcsanyi, J. Effect of capsaicin on thermoregulation: an update with new aspects. Temperature (Austin) 2, 277\u2013296, https:\/\/doi.org\/10.1080\/23328940.2015.1048928 (2015).","journal-title":"Temperature (Austin)"},{"key":"65703_CR38","doi-asserted-by":"publisher","first-page":"9069","DOI":"10.1523\/JNEUROSCI.0877-06.2006","volume":"26","author":"S Ciura","year":"2006","unstructured":"Ciura, S. & Bourque, C. W. Transient receptor potential vanilloid 1 is required for intrinsic osmoreception in organum vasculosum lamina terminalis neurons and for normal thirst responses to systemic hyperosmolality. J Neurosci 26, 9069\u20139075, https:\/\/doi.org\/10.1523\/JNEUROSCI.0877-06.2006 (2006).","journal-title":"J Neurosci"},{"key":"65703_CR39","doi-asserted-by":"publisher","first-page":"14669","DOI":"10.1523\/JNEUROSCI.1420-11.2011","volume":"31","author":"S Ciura","year":"2011","unstructured":"Ciura, S., Liedtke, W. & Bourque, C. W. Hypertonicity sensing in organum vasculosum lamina terminalis neurons: a mechanical process involving TRPV1 but not TRPV4. J Neurosci 31, 14669\u201314676, https:\/\/doi.org\/10.1523\/JNEUROSCI.1420-11.2011 (2011).","journal-title":"J Neurosci"},{"key":"65703_CR40","doi-asserted-by":"publisher","first-page":"957","DOI":"10.1002\/glia.22488","volume":"61","author":"T Mannari","year":"2013","unstructured":"Mannari, T., Morita, S., Furube, E., Tominaga, M. & Miyata, S. Astrocytic TRPV1 ion channels detect blood-borne signals in the sensory circumventricular organs of adult mouse brains. Glia 61, 957\u2013971, https:\/\/doi.org\/10.1002\/glia.22488 (2013).","journal-title":"Glia"},{"key":"65703_CR41","doi-asserted-by":"publisher","first-page":"R669","DOI":"10.1152\/ajpregu.00270.2013","volume":"305","author":"CD Sladek","year":"2013","unstructured":"Sladek, C. D. & Johnson, A. K. Integration of thermal and osmotic regulation of water homeostasis: the role of TRPV channels. Am J Physiol Regul Integr Comp Physiol 305, R669\u2013678, https:\/\/doi.org\/10.1152\/ajpregu.00270.2013 (2013).","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"key":"65703_CR42","doi-asserted-by":"publisher","first-page":"220","DOI":"10.1016\/0006-8993(91)91321-q","volume":"550","author":"TA Roeling","year":"1991","unstructured":"Roeling, T. A., van Erp, A. M., Meelis, W., Kruk, M. R. & Veening, J. G. Behavioural effects of NMDA injected into the hypothalamic paraventricular nucleus of the rat. Brain Res 550, 220\u2013224, https:\/\/doi.org\/10.1016\/0006-8993(91)91321-q (1991).","journal-title":"Brain Res"},{"key":"65703_CR43","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1111\/apha.12487","volume":"214","author":"MJ McKinley","year":"2015","unstructured":"McKinley, M. J. et al. The median preoptic nucleus: front and centre for the regulation of body fluid, sodium, temperature, sleep and cardiovascular homeostasis. Acta Physiol (Oxf) 214, 8\u201332, https:\/\/doi.org\/10.1111\/apha.12487 (2015).","journal-title":"Acta Physiol (Oxf)"},{"key":"65703_CR44","doi-asserted-by":"publisher","first-page":"6951","DOI":"10.1073\/pnas.111025298","volume":"98","author":"M Tominaga","year":"2001","unstructured":"Tominaga, M., Wada, M. & Masu, M. Potentiation of capsaicin receptor activity by metabotropic ATP receptors as a possible mechanism for ATP-evoked pain and hyperalgesia. Proc Natl Acad Sci USA 98, 6951\u20136956, https:\/\/doi.org\/10.1073\/pnas.111025298 (2001).","journal-title":"Proc Natl Acad Sci USA"},{"key":"65703_CR45","doi-asserted-by":"publisher","first-page":"197","DOI":"10.2174\/157015906778019554","volume":"4","author":"J Huang","year":"2006","unstructured":"Huang, J., Zhang, X. & McNaughton, P. A. Inflammatory pain: the cellular basis of heat hyperalgesia. Curr Neuropharmacol 4, 197\u2013206, https:\/\/doi.org\/10.2174\/157015906778019554 (2006).","journal-title":"Curr Neuropharmacol"},{"key":"65703_CR46","doi-asserted-by":"publisher","DOI":"10.1186\/s12974-015-0324-6","volume":"12","author":"W Lee","year":"2015","unstructured":"Lee, W., Moon, M., Kim, H. G., Lee, T. H. & Oh, M. S. Heat stress-induced memory impairment is associated with neuroinflammation in mice. J Neuroinflammation 12, 102, https:\/\/doi.org\/10.1186\/s12974-015-0324-6 (2015).","journal-title":"J Neuroinflammation"},{"key":"65703_CR47","doi-asserted-by":"publisher","first-page":"1827","DOI":"10.1111\/j.1432-1033.2004.04081.x","volume":"271","author":"M Van Der Stelt","year":"2004","unstructured":"Van Der Stelt, M. & Di Marzo, V. Endovanilloids. Putative endogenous ligands of transient receptor potential vanilloid 1 channels. Eur J Biochem 271, 1827\u20131834, https:\/\/doi.org\/10.1111\/j.1432-1033.2004.04081.x (2004).","journal-title":"Eur J Biochem"},{"key":"65703_CR48","doi-asserted-by":"publisher","first-page":"487","DOI":"10.3389\/fnmol.2018.00487","volume":"11","author":"C Muller","year":"2018","unstructured":"Muller, C., Morales, P. & Reggio, P. H. Cannabinoid Ligands Targeting TRP Channels. Front Mol Neurosci 11, 487, https:\/\/doi.org\/10.3389\/fnmol.2018.00487 (2018).","journal-title":"Front Mol Neurosci"},{"key":"65703_CR49","doi-asserted-by":"publisher","first-page":"611","DOI":"10.1016\/j.ceca.2009.03.003","volume":"45","author":"L De Petrocellis","year":"2009","unstructured":"De Petrocellis, L. & Di Marzo, V. Role of endocannabinoids and endovanilloids in Ca2+ signalling. Cell Calcium 45, 611\u2013624, https:\/\/doi.org\/10.1016\/j.ceca.2009.03.003 (2009).","journal-title":"Cell Calcium"},{"key":"65703_CR50","doi-asserted-by":"publisher","first-page":"1465","DOI":"10.4049\/jimmunol.1602151","volume":"199","author":"SK Lawton","year":"2017","unstructured":"Lawton, S. K. et al. N-Arachidonoyl Dopamine Modulates Acute Systemic Inflammation via Nonhematopoietic TRPV1. J Immunol 199, 1465\u20131475, https:\/\/doi.org\/10.4049\/jimmunol.1602151 (2017).","journal-title":"J Immunol"},{"key":"65703_CR51","unstructured":"Paxinos, G. & Franklin, K. The Mouse Brain in Stereotaxic Coordinates. (Academic Press, San Diego, 2007)."},{"key":"65703_CR52","doi-asserted-by":"publisher","first-page":"58","DOI":"10.1016\/j.jneuroim.2018.04.017","volume":"331","author":"Shiori Muneoka","year":"2019","unstructured":"Muneoka, S., Murayama, S., Nakano, Y. & Miyata, S. TLR4 in circumventricular neural stem cells is a negative regulator for thermogenic pathways in the mouse brain. J Neuroimmunol, https:\/\/doi.org\/10.1016\/j.jneuroim.2018.04.017 (2018).","journal-title":"Journal of Neuroimmunology"},{"key":"65703_CR53","doi-asserted-by":"publisher","first-page":"739","DOI":"10.1016\/j.jpain.2008.03.008","volume":"9","author":"CJ Vierck","year":"2008","unstructured":"Vierck, C. J., Acosta-Rua, A. J., Rossi, H. L. & Neubert, J. K. Sex differences in thermal pain sensitivity and sympathetic reactivity for two strains of rat. J Pain 9, 739\u2013749, https:\/\/doi.org\/10.1016\/j.jpain.2008.03.008 (2008).","journal-title":"J Pain"},{"key":"65703_CR54","doi-asserted-by":"crossref","unstructured":"Gordon, C. J. Temperature regulation in laboratory rodents. (Cambridge University Press, 1993).","DOI":"10.1017\/CBO9780511565595"},{"key":"65703_CR55","doi-asserted-by":"publisher","first-page":"1646","DOI":"10.1080\/07420528.2019.1663863","volume":"36","author":"C Harding","year":"2019","unstructured":"Harding, C. et al. The daily, weekly, and seasonal cycles of body temperature analyzed at large scale. Chronobiol Int 36, 1646\u20131657, https:\/\/doi.org\/10.1080\/07420528.2019.1663863 (2019).","journal-title":"Chronobiol Int"}],"container-title":["Scientific Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41598-020-65703-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-020-65703-9","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-020-65703-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,12,6]],"date-time":"2022-12-06T11:57:00Z","timestamp":1670327820000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41598-020-65703-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,5,29]]},"references-count":55,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2020,12]]}},"alternative-id":["65703"],"URL":"https:\/\/doi.org\/10.1038\/s41598-020-65703-9","relation":{},"ISSN":["2045-2322"],"issn-type":[{"value":"2045-2322","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,5,29]]},"assertion":[{"value":"12 December 2019","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"4 May 2020","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"29 May 2020","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"8799"}}