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We reviewed 86 paraquat-intoxicated survivors between 2000 and 2012 in Chang Gung Memorial Hospital, a 3700-bed tertiary hospital in Taiwan. With all the patients underwent same detoxification protocol in the acute stage, 17.4% of paraquat poisoning survivors developed ON of femoral head requiring surgery during follow up. Most of ON episodes occurred within 2 to 4 years after paraquat intoxication and then plateau after 6 years. ON patients exhibited higher SOFA scores than non-ON patients (2.80\u2009\u00b1\u20092.14 vs. 1.76\u2009\u00b1\u20091.52, p\u2009=\u20090.028). Furthermore, AKIN scores are also higher in the ON patients than non-ON patients (0.87\u2009\u00b1\u20091.13 vs. 0.38\u2009\u00b1\u20090.74, p\u2009=\u20090.040). Multivariate logistic regression showed higher AKIN score and higher partial pressure of carbon dioxide in the blood 48\u2009hours after admission significantly predicted ON of femoral head after paraquat intoxication (p\u2009=\u20090.002 and p\u2009=\u20090.006 respectively). Larger studies with longer follow-up durations are warranted to confirm our finding.<\/jats:p>","DOI":"10.1038\/s41598-020-65756-w","type":"journal-article","created":{"date-parts":[[2020,6,1]],"date-time":"2020-06-01T10:03:14Z","timestamp":1591005794000},"update-policy":"http:\/\/dx.doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Osteonecrosis of Femoral Head, An Overlooked Long-Term Complication after Paraquat Intoxication: A Retrospective Cohort Study"],"prefix":"10.1038","volume":"10","author":[{"given":"Ming-Jen","family":"Chan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chien-Chang","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ching-Chih","family":"Hu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wen-Hung","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ching-Wei","family":"Hsu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tzung-Hai","family":"Yen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cheng-Hao","family":"Weng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2020,6,1]]},"reference":[{"key":"65756_CR1","doi-asserted-by":"publisher","first-page":"e112160","DOI":"10.1371\/journal.pone.0112160","volume":"9","author":"C Lin","year":"2014","unstructured":"Lin, C., Yen, T. 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