{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,24]],"date-time":"2026-04-24T02:54:52Z","timestamp":1776999292501,"version":"3.51.4"},"reference-count":24,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2020,6,1]],"date-time":"2020-06-01T00:00:00Z","timestamp":1590969600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2020,6,1]],"date-time":"2020-06-01T00:00:00Z","timestamp":1590969600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Kyphoplasty is the standard surgical treatment of vertebral compression fractures. We aimed to clarify the influence of kyphoplasty on the sagittal profile as well as the relation between posture improvement and pain relief. For this purpose, we evaluated various radiological parameters of the sagittal profile on whole spine standing radiographs of 73 Patients with a single vertebral fracture treated by kyphoplasty. The key outcome was the postoperative change of the sagittal vertical axis (SVA). Additionally, clinical parameters including pain scores on visual analogue scale (VAS) and use of analgesics were obtained from medical records. Pre- and postoperative radiological as well as clinical parameters were compared. Additionally, the correlation between changes of SVA and changes of local kyphotic angle (LKA) or VAS was examined. The clinical parameters as well as various radiographic parameters (SVA, LKA, Gardner, Cobb) improved significantly postoperatively. The improvement of SVA correlated significantly with the correction of the LKA but not with postoperative pain relief. We conclude that kyphoplasty helps to restore the global sagittal balance of the spine after vertebral fractures. The correction of the sagittal profile seems to depend on the correction of the local kyphotic angle but does not correlate with postoperative pain relief.<\/jats:p>","DOI":"10.1038\/s41598-020-65798-0","type":"journal-article","created":{"date-parts":[[2020,6,1]],"date-time":"2020-06-01T10:03:14Z","timestamp":1591005794000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Kyphoplasty Restores the Global Sagittal Balance of the Spine Independently from Pain Reduction"],"prefix":"10.1038","volume":"10","author":[{"given":"Matthias","family":"Pumberger","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Florian","family":"Schitz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Justus","family":"B\u00fcrger","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Friederike","family":"Sch\u00f6mig","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Putzier","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yannick","family":"Palmowski","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2020,6,1]]},"reference":[{"key":"65798_CR1","doi-asserted-by":"publisher","first-page":"1726","DOI":"10.1007\/s00198-006-0172-4","volume":"17","author":"O Johnell","year":"2006","unstructured":"Johnell, O. & Kanis, J. A. An estimate of the worldwide prevalence and disability associated with osteoporotic fractures. Osteoporos Int 17, 1726\u20131733, https:\/\/doi.org\/10.1007\/s00198-006-0172-4 (2006).","journal-title":"Osteoporos Int"},{"key":"65798_CR2","doi-asserted-by":"publisher","first-page":"179S","DOI":"10.1016\/8756-3282(95)00499-8","volume":"18","author":"RD Wasnich","year":"1996","unstructured":"Wasnich, R. D. Vertebral fracture epidemiology. Bone 18, 179S\u2013183S (1996).","journal-title":"Bone"},{"key":"65798_CR3","doi-asserted-by":"publisher","first-page":"429","DOI":"10.1007\/s00198-003-1395-2","volume":"14","author":"HW Finnern","year":"2003","unstructured":"Finnern, H. W. & Sykes, D. P. The hospital cost of vertebral fractures in the EU: estimates using national datasets. Osteoporos Int 14, 429\u2013436, https:\/\/doi.org\/10.1007\/s00198-003-1395-2 (2003).","journal-title":"Osteoporos Int"},{"key":"65798_CR4","doi-asserted-by":"publisher","first-page":"604","DOI":"10.1359\/JBMR.041203","volume":"20","author":"C Kasperk","year":"2005","unstructured":"Kasperk, C. et al. Treatment of painful vertebral fractures by kyphoplasty in patients with primary osteoporosis: a prospective nonrandomized controlled study. J Bone Miner Res 20, 604\u2013612, https:\/\/doi.org\/10.1359\/JBMR.041203 (2005).","journal-title":"J Bone Miner Res"},{"key":"65798_CR5","unstructured":"Dachverband Osteologie e.V. Prophylaxe, Diagnostik und Therapie der Osteoporose. (2017)."},{"key":"65798_CR6","doi-asserted-by":"publisher","first-page":"496","DOI":"10.1007\/s00586-004-0691-7","volume":"13","author":"U Berlemann","year":"2004","unstructured":"Berlemann, U., Franz, T., Orler, R. & Heini, P. F. Kyphoplas; ty for treatment of osteoporotic vertebral fractures: a prospective non-randomized study. Eur Spine J 13, 496\u2013501, https:\/\/doi.org\/10.1007\/s00586-004-0691-7 (2004).","journal-title":"Eur Spine J"},{"key":"65798_CR7","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1007\/s00264-012-1709-0","volume":"37","author":"R Dong","year":"2013","unstructured":"Dong, R. et al. Pain reduction following vertebroplasty and kyphoplasty. Int Orthop 37, 83\u201387, https:\/\/doi.org\/10.1007\/s00264-012-1709-0 (2013).","journal-title":"Int Orthop"},{"key":"65798_CR8","doi-asserted-by":"publisher","first-page":"1935","DOI":"10.1002\/jbmr.3170","volume":"32","author":"AJ Rodriguez","year":"2017","unstructured":"Rodriguez, A. J. et al. Pain, Quality of Life, and Safety Outcomes of Kyphoplasty for Vertebral Compression Fractures: Report of a Task Force of the American Society for Bone and Mineral Research. J Bone Miner Res 32, 1935\u20131944, https:\/\/doi.org\/10.1002\/jbmr.3170 (2017).","journal-title":"J Bone Miner Res"},{"key":"65798_CR9","doi-asserted-by":"publisher","first-page":"419","DOI":"10.1359\/JBMR.051201","volume":"21","author":"MH Huang","year":"2006","unstructured":"Huang, M. H., Barrett-Connor, E., Greendale, G. A. & Kado, D. M. Hyperkyphotic; posture and risk of future osteoporotic fractures: the Rancho Bernardo study. J Bone Miner Res 21, 419\u2013423, https:\/\/doi.org\/10.1359\/JBMR.051201 (2006).","journal-title":"J Bone Miner Res"},{"key":"65798_CR10","doi-asserted-by":"publisher","first-page":"1824","DOI":"10.1007\/s00586-010-1476-9","volume":"19","author":"P Roussouly","year":"2010","unstructured":"Roussouly, P. & Nnadi, C. Sagittal plane deformity: an overview of interpretation and management. Eur Spine J 19, 1824\u20131836, https:\/\/doi.org\/10.1007\/s00586-010-1476-9 (2010).","journal-title":"Eur Spine J"},{"key":"65798_CR11","doi-asserted-by":"publisher","first-page":"553","DOI":"10.1016\/j.math.2015.01.001","volume":"20","author":"CJ Sorensen","year":"2015","unstructured":"Sorensen, C. J., Norton, B. J., Callaghan, J. P., Hwang, C. T. & Van Dillen, L. R. Is lumbar lordosis related to low back pain development during prolonged standing? Man Ther 20, 553\u2013557, https:\/\/doi.org\/10.1016\/j.math.2015.01.001 (2015).","journal-title":"Man Ther"},{"key":"65798_CR12","doi-asserted-by":"publisher","first-page":"669","DOI":"10.3174\/ajnr.A1442","volume":"30","author":"A Hiwatashi","year":"2009","unstructured":"Hiwatashi, A. et al. Kyphoplasty and vertebroplasty produce the same degree; of height restoration. AJNR Am J Neuroradiol 30, 669\u2013673, https:\/\/doi.org\/10.3174\/ajnr.A1442 (2009).","journal-title":"AJNR Am J Neuroradiol"},{"key":"65798_CR13","doi-asserted-by":"publisher","first-page":"338","DOI":"10.1097\/BSD.0b013e318224a6e6","volume":"25","author":"KH Kim","year":"2012","unstructured":"Kim, K. H. et al. Kyphoplasty versus vertebroplasty: restoration of vertebral body height and correction of kyphotic deformity with special attention to the shape of the fractured vertebrae. J Spinal Disord Tech 25, 338\u2013344, https:\/\/doi.org\/10.1097\/BSD.0b013e318224a6e6 (2012).","journal-title":"J Spinal Disord Tech"},{"key":"65798_CR14","doi-asserted-by":"publisher","first-page":"1474","DOI":"10.3174\/ajnr.A3424","volume":"34","author":"K Yokoyama","year":"2013","unstructured":"Yokoyama, K. et al. In not only vertebroplasty but also kyphop; lasty, the resolution of vertebral deformities depends on vertebral mobility. AJNR Am J Neuroradiol 34, 1474\u20131478, https:\/\/doi.org\/10.3174\/ajnr.A3424 (2013).","journal-title":"AJNR Am J Neuroradiol"},{"key":"65798_CR15","doi-asserted-by":"publisher","first-page":"1137","DOI":"10.1007\/s00264-015-2737-3","volume":"39","author":"M Kanayama","year":"2015","unstructured":"Kanayama, M., Oha, F., Iwata, A. & Hashimoto, T. Does balloon kyphoplasty improve the global spinal alignment in osteoporotic vertebral fracture? Int Orthop 39, 1137\u20131143, https:\/\/doi.org\/10.1007\/s00264-015-2737-3 (2015).","journal-title":"Int Orthop"},{"key":"65798_CR16","doi-asserted-by":"publisher","first-page":"293","DOI":"10.1097\/BSD.0b013e31812e6295","volume":"21","author":"P Korovessis","year":"2008","unstructured":"Korovessis, P., Zacharatos, S., Repantis, T., Michael, A. & Karachalios, D. Evolution of; bone mineral density after percutaneous kyphoplasty in fresh osteoporotic vertebral body fractures and adjacent vertebrae along with sagittal spine alignment. J Spinal Disord Tech 21, 293\u2013298, https:\/\/doi.org\/10.1097\/BSD.0b013e31812e6295 (2008).","journal-title":"J Spinal Disord Tech"},{"key":"65798_CR17","doi-asserted-by":"publisher","first-page":"744","DOI":"10.1007\/s00586-014-3678-z","volume":"24","author":"K Yokoyama","year":"2015","unstructured":"Yokoyama, K. et al. Postoperative change in sagittal balance after Kyphoplasty for the treatment of osteoporotic vertebral compression fracture. Eur Spine J 24, 744\u2013749, https:\/\/doi.org\/10.1007\/s00586-014-3678-z (2015).","journal-title":"Eur Spine J"},{"key":"65798_CR18","doi-asserted-by":"publisher","first-page":"435","DOI":"10.1097\/01.brs.0000200036.08679.1e","volume":"31","author":"BB Pradhan","year":"2006","unstructured":"Pradhan, B. B., Bae, H. W., Kropf, M. A., Patel, V. V. & Delamarter, R. B. Kyphoplasty; reduction of osteoporotic vertebral compression fractures: correction of local kyphosis versus overall sagittal alignment. Spine (Phila Pa 1976) 31, 435\u2013441, https:\/\/doi.org\/10.1097\/01.brs.0000200036.08679.1e (2006).","journal-title":"Spine (Phila Pa 1976)"},{"key":"65798_CR19","unstructured":"Ferraris, L., Koller, H., Meier, O. & Hempfing, A. Die Bedeutung der sagittalen Balance in der Wirbels\u00e4ulenchirurgie. OUP 1, 502-508, doi:10.3238\/oup.2012.0502\u20130508 (2012)."},{"key":"65798_CR20","doi-asserted-by":"publisher","first-page":"199","DOI":"10.3340\/jkns.2010.47.3.199","volume":"47","author":"GS Oh","year":"2010","unstructured":"Oh, G. S. et al. Comparison of the results of balloon kyphoplasty performed at different times after injury. J Korean Neurosurg Soc 47, 199\u2013202, https:\/\/doi.org\/10.3340\/jkns.2010.47.3.199 (2010).","journal-title":"J Korean Neurosurg Soc"},{"issue":"5","key":"65798_CR21","doi-asserted-by":"publisher","first-page":"489","DOI":"10.1097\/BCO.0b013e3181e56d96","volume":"21","author":"Hyung Taek Park","year":"2010","unstructured":"Park, H. T. L., Chang Bum; Ha, Jeong Han; Choi, Sun Jin; Kim, Myoung Soo; Ha, Jung; Min. Results of kyphoplasty according to the operative timing. Current Orthopaedic Practice 21, p. 489-493 (2010).","journal-title":"Current Orthopaedic Practice"},{"key":"65798_CR22","doi-asserted-by":"publisher","first-page":"120","DOI":"10.1016\/S1529-9430(02)00382-0","volume":"2","author":"BL Vivek Kushwaha","year":"2002","unstructured":"Vivek Kushwaha, B. L. Vertebral height restoration after kyphoplasty. The Spine Journal 2, 120 (2002).","journal-title":"The Spine Journal"},{"key":"65798_CR23","doi-asserted-by":"crossref","unstructured":"Gold, D. & Lyles, K. Fractures: effects on quality of life. in: Bilezikian JP, Glowacki J, Rosen CJ, eds. The Aging Skeleton San Diego: Academic Press, p. 373-382 (1999).","DOI":"10.1016\/B978-012098655-2\/50034-X"},{"issue":"Suppl 2","key":"65798_CR24","doi-asserted-by":"publisher","first-page":"S27","DOI":"10.1016\/8756-3282(92)90193-z","volume":"13","author":"SL Silverman","year":"1992","unstructured":"Silverman, S. L. The clinical consequences of vertebral compression; fracture. Bone 13(Suppl 2), S27\u201331, https:\/\/doi.org\/10.1016\/8756-3282(92)90193-z (1992).","journal-title":"Bone"}],"container-title":["Scientific Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41598-020-65798-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-020-65798-0","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-020-65798-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,12,6]],"date-time":"2022-12-06T11:30:11Z","timestamp":1670326211000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41598-020-65798-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,6,1]]},"references-count":24,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2020,12]]}},"alternative-id":["65798"],"URL":"https:\/\/doi.org\/10.1038\/s41598-020-65798-0","relation":{},"ISSN":["2045-2322"],"issn-type":[{"value":"2045-2322","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,6,1]]},"assertion":[{"value":"23 December 2019","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 May 2020","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"1 June 2020","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"8894"}}