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Despite the availability of antifungal treatments, mortality rates are still unacceptably high and drug resistance is increasing. We, therefore, generated the Ca37 monoclonal antibody against the <jats:italic>C. albicans<\/jats:italic> alcohol dehydrogenase (Adh) 1. Our data showed that Ca37 was able to detect <jats:italic>C. albicans<\/jats:italic> cells, and it bound to Adh1 in yeast and Adh2 in hyphae among the cell wall-associated proteins. Moreover, Ca37 was able to inhibit candidal growth following 18\u2009h incubation time and reduced the minimal inhibitory concentration of amphotericin B or fluconazole when used in combination with those antifungals. In addition, the antibody prolonged the survival of <jats:italic>C. albicans<\/jats:italic> infected-<jats:italic>Galleria mellonella<\/jats:italic> larvae, when <jats:italic>C. albicans<\/jats:italic> was exposed to antibody prior to inoculating <jats:italic>G. mellonella<\/jats:italic> or by direct application as a therapeutic agent on infected larvae. In conclusion, the Ca37 monoclonal antibody proved to be effective against <jats:italic>C. albicans<\/jats:italic>, both <jats:italic>in vitro<\/jats:italic> and <jats:italic>in vivo<\/jats:italic>, and to act together with antifungal drugs, suggesting Adh proteins could be interesting therapeutic targets against this pathogen.<\/jats:p>","DOI":"10.1038\/s41598-020-65859-4","type":"journal-article","created":{"date-parts":[[2020,6,8]],"date-time":"2020-06-08T10:05:16Z","timestamp":1591610716000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["The monoclonal antibody Ca37, developed against Candida albicans alcohol dehydrogenase, inhibits the yeast in vitro and in vivo"],"prefix":"10.1038","volume":"10","author":[{"given":"Aitziber","family":"Antoran","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leire","family":"Aparicio-Fernandez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aize","family":"Pellon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Idoia","family":"Buldain","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leire","family":"Martin-Souto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aitor","family":"Rementeria","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahmoud A.","family":"Ghannoum","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beth Burgwyn","family":"Fuchs","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eleftherios","family":"Mylonakis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernando L.","family":"Hernando","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andoni","family":"Ramirez-Garcia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2020,6,8]]},"reference":[{"key":"65859_CR1","doi-asserted-by":"publisher","first-page":"1284","DOI":"10.1093\/cid\/cit006","volume":"56","author":"CJ Clancy","year":"2013","unstructured":"Clancy, C. 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