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Matrix metalloproteinases (MMPs) and angiotensin-converting enzyme (ACE) have been implicated in the pathogenesis of arrhythmia. However, the relationship between these molecules and acquired AVB is still unclear. One hundred and two patients with documented acquired AVB and 100 controls were studied. Gene polymorphisms of the MMP1 and ACE encoding genes were screened by the gene sequencing method or polymerase chain reaction-fragment length polymorphism assay, followed by an association study. The frequencies of the MMP1 \u22121607 2G2G genotype and MMP1 \u22121607 2\u2009G allele were significantly higher in the AVB group than that in the controls (OR\u2009=\u20091.933, P\u2009=\u20090.027 and OR\u2009=\u20091.684, P\u2009=\u20090.012, respectively). Consistently, the level of serum MMP1 was significantly greater in acquired AVB patients than that in controls (6568.9\u2009\u00b1\u20095748.6\u2009pg\/ml vs. 4730.5\u2009\u00b1\u20093377.1\u2009pg\/ml, P\u2009=\u20090.019). In addition, the MMP1 2G2G genotype showed a higher MMP-1 serum level than the other genotypes (1G1G\/1G2G) (7048.1\u2009\u00b1\u20095683.0\u2009pg\/ml vs. 5072.4\u2009\u00b1\u20094267.6\u2009pg\/ml, P\u2009=\u20090.042). MMP1 1\u2009G\/2\u2009G gene polymorphism may contribute to determining the disease susceptibility of acquired AVB by linking the MMP serum protein level.<\/jats:p>","DOI":"10.1038\/s41598-020-66896-9","type":"journal-article","created":{"date-parts":[[2020,6,18]],"date-time":"2020-06-18T10:03:26Z","timestamp":1592474606000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Matrix metalloproteinase 1 1\u2009G\/2\u2009G gene polymorphism is associated with acquired atrioventricular block via linking a higher serum protein level"],"prefix":"10.1038","volume":"10","author":[{"given":"Jan-Yow","family":"Chen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kuan-Cheng","family":"Chang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying-Ming","family":"Liou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2020,6,18]]},"reference":[{"key":"66896_CR1","doi-asserted-by":"publisher","first-page":"703","DOI":"10.1056\/NEJM200003093421006","volume":"342","author":"JM Mangrum","year":"2000","unstructured":"Mangrum, J. 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