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Germicidal ultraviolet light, typically at 254\u2009nm, is effective in this context but, used directly, can be a health hazard to skin and eyes. By contrast, far-UVC light (207\u2013222\u2009nm) efficiently kills pathogens potentially without harm to exposed human tissues. We previously demonstrated that 222-nm far-UVC light efficiently kills airborne influenza virus and we extend those studies to explore far-UVC efficacy against airborne human coronaviruses alpha HCoV-229E and beta HCoV-OC43. Low doses of 1.7 and 1.2 mJ\/cm\n                    <jats:sup>2<\/jats:sup>\n                    inactivated 99.9% of aerosolized coronavirus 229E and OC43,\u00a0respectively. As all human coronaviruses have similar genomic sizes, far-UVC light would be expected to show similar inactivation efficiency against other human coronaviruses including SARS-CoV-2. Based on the beta-HCoV-OC43 results, continuous far-UVC exposure in occupied public locations at the current regulatory exposure limit (~3 mJ\/cm\n                    <jats:sup>2<\/jats:sup>\n                    \/hour) would result in ~90% viral inactivation in ~8\u2009minutes, 95% in ~11\u2009minutes, 99% in ~16\u2009minutes and 99.9% inactivation in ~25\u2009minutes. Thus while staying within current regulatory dose limits, low-dose-rate far-UVC exposure can potentially safely provide a major reduction in the ambient level of airborne coronaviruses in occupied public locations.\n                  <\/jats:p>","DOI":"10.1038\/s41598-020-67211-2","type":"journal-article","created":{"date-parts":[[2020,6,24]],"date-time":"2020-06-24T06:02:52Z","timestamp":1592978572000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":628,"title":["Far-UVC light (222\u2009nm) efficiently and safely inactivates airborne human coronaviruses"],"prefix":"10.1038","volume":"10","author":[{"given":"Manuela","family":"Buonanno","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Welch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Igor","family":"Shuryak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David J.","family":"Brenner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2020,6,24]]},"reference":[{"key":"67211_CR1","unstructured":"World Health Organization. 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Appropriate editorial action will be taken once this matter is resolved and all parties have been given an opportunity to respond in full.","order":6,"name":"change_details","label":"Change Details","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"27 September 2021","order":7,"name":"change_date","label":"Change Date","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Correction","order":8,"name":"change_type","label":"Change Type","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"A Correction to this paper has been published:","order":9,"name":"change_details","label":"Change Details","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"https:\/\/doi.org\/10.1038\/s41598-021-97508-9","URL":"https:\/\/doi.org\/10.1038\/s41598-021-97508-9","order":10,"name":"change_details","label":"Change Details","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"D.J.B has a granted patent entitled \u2018Apparatus, method and system for selectively affecting and\/or killing a virus\u2019 (US10780189B2), that relates to the use of filtered 222 nm UV light to inactivate viruses. In addition, D.J.B has an ongoing non-financial collaboration with Eden Park Illumination, and the authors\u2019 institution, Columbia University, has licensed aspects of UV light technology to USHIO Inc.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"10285"}}