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Previously, abnormal structure, phonation-related and resting-state sensorimotor abnormalities as well as peripheral tactile thresholds in ADSD were described. This study aimed at\u00a0assessing abnormal central tactile processing patterns, their spatial relation with dysfunctional resting-state connectivity, and their BoNT-A responsiveness. Functional MRI in 14\/12 ADSD patients before\/under BoNT-A effect and 15 controls was performed (i) during automatized tactile stimulus application to face\/hand, and (ii) at rest. Between-group differential stimulation-induced activation and resting-state connectivity (regional homogeneity, connectivity strength within selected sensory(motor) networks), as well as within-patient BoNT-A effects on these differences were investigated. Contralateral-to-stimulation overactivity in ADSD before BoNT-A involved primary and secondary somatosensory representations, along with abnormalities in higher-order parietal, insular, temporal or premotor cortices. Dysphonic impairment in ADSD positively associated with left-hemispheric temporal activity. Connectivity was increased within right premotor (sensorimotor network), left primary auditory cortex (auditory network), and regionally reduced at the temporoparietal junction. Activation\/connectivity before\/after BoNT-A within-patients did not significantly differ. Abnormal ADSD central somatosensory processing supports its significance as common pathophysiologic focal dystonia trait. Abnormal temporal cortex tactile processing and resting-state connectivity might hint at abnormal cross-modal sensory interactions.<\/jats:p>","DOI":"10.1038\/s41598-020-67295-w","type":"journal-article","created":{"date-parts":[[2020,6,23]],"date-time":"2020-06-23T10:02:51Z","timestamp":1592906571000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Altered sensory system activity and connectivity patterns in adductor spasmodic dysphonia"],"prefix":"10.1038","volume":"10","author":[{"given":"Tobias","family":"Mantel","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Dresel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Welte","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tobias","family":"Meindl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angela","family":"Jochim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claus","family":"Zimmer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernhard","family":"Haslinger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2020,6,23]]},"reference":[{"key":"67295_CR1","doi-asserted-by":"publisher","first-page":"926","DOI":"10.1002\/mds.25567","volume":"28","author":"HA Jinnah","year":"2013","unstructured":"Jinnah, H. 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Mantel receives research support from the KKF (H-05). T. Meindl has received travel grants from Pharm-Allergan GmbH, Ipsen Pharma GmbH, Merz Pharma GmbH & Co. KGaA. A. Jochim has received travel grants by Merz Pharma GmbH & Co. KGaA as well as speaker honoraria by Pharm-Allergan GmbH and Merz Pharma GmbH & Co. KGaA.C. Zimmer has served on scientific advisory boards for Philips. He has received speaker honoraria from Philips. He serves as co-editor on the Advisory Board of Clinical Neuroradiology. C. Dresel received research support from the DFG (DFG HA3370\/3-1). B. Haslinger received research support from Ipsen Pharma GmbH and the DFG (DFG HA3370\/5-1), has received speaker honoraria from Pharm-Allergan GmbH and Ipsen Pharma GmbH and has received travel grants from Ipsen Pharma GmbH and Merz Pharmaceuticals GmbH. He has received royalties for book chapters from Cambridge University Press and Springer Medizin. The other authors report no disclosures.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"10179"}}