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This study aims to develop a new registration algorithm with enhanced accuracy and efficiency. Ten setup errors with different translation and rotation were simulated with the phantom. For each error, one set of simulated computer tomography images and EPID images were acquired and registered with the traditional and the new method. The traditional method was performed by two senior physicists with the Varian Offline Review software. The new method is basing on the comparison of the precise contours of the same bone structure in the digital reconstruction radiography images and the EPID images, and the contours were fitted with an automatic edge detection algorithm based on gradient images. The average error of the new method was decreased by 44.44%, 28.33%, 49.09% in the translation of X, Y, and Z axes (The traditional vs. the new: X axes, 0.45\u00a0mm vs. 0.25\u00a0mm; Y axes, 0.75\u00a0mm vs. 0.35\u00a0mm; Z axes, 0.55\u00a0mm vs. 0.28\u00a0mm), 42.86% and 40.48% in the rotation of X and Z axes (The traditional vs. the new: X axes, 0.49\u00b0 vs. 0.28\u00b0; Z axes, 0.42\u00b0 vs. 0.25\u00b0), respectively. The average elapsed time in the new method was reduced by 11.14% (The traditional vs. the new: 44\u00a0s vs. 39.1\u00a0s). The new registration method has significant advantages of accuracy and efficiency compared with the traditional method.<\/jats:p>","DOI":"10.1038\/s41598-020-67331-9","type":"journal-article","created":{"date-parts":[[2020,6,24]],"date-time":"2020-06-24T06:02:52Z","timestamp":1592978572000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["A new registration algorithm of electronic portal imaging devices images based on the automatic detection of bone edges during radiotherapy"],"prefix":"10.1038","volume":"10","author":[{"given":"Cheng","family":"Chen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chaoyan","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yahua","family":"Zhong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Conghua","family":"Xie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunfeng","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiuling","family":"Sheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dazheng","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongli","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haijun","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2020,6,24]]},"reference":[{"key":"67331_CR1","doi-asserted-by":"publisher","first-page":"171","DOI":"10.1002\/mp.13893","volume":"47","author":"I Olaciregui-Ruiz","year":"2020","unstructured":"Olaciregui-Ruiz, I., Rozendaal, R., van Kranen, S., Mijnheer, B. & Mans, A. 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Clinical implementation of a model-based in vivo dose verification system for stereotactic body radiation therapy-volumetric modulated arc therapy treatments using the electronic portal imaging device. Int. J. Radiat. Oncol. Biol. Phys. 97, 1077\u20131084. https:\/\/doi.org\/10.1016\/j.ijrobp.2017.01.227 (2017).","journal-title":"Int. J. Radiat. Oncol. Biol. Phys."},{"key":"67331_CR4","doi-asserted-by":"publisher","first-page":"5650","DOI":"10.1002\/mp.12572","volume":"44","author":"YH Hu","year":"2017","unstructured":"Hu, Y. H. et al. A novel method for quantification of beam\u2019s-eye-view tumor tracking performance. Med. Phys. 44, 5650\u20135659. https:\/\/doi.org\/10.1002\/mp.12572 (2017).","journal-title":"Med. Phys."},{"key":"67331_CR5","doi-asserted-by":"publisher","first-page":"204","DOI":"10.1016\/j.ijrobp.2013.09.045","volume":"88","author":"SL Berry","year":"2014","unstructured":"Berry, S. L. et al. 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