{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T06:23:30Z","timestamp":1791267810251,"version":"4.1.0"},"reference-count":25,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2020,6,30]],"date-time":"2020-06-30T00:00:00Z","timestamp":1593475200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2020,6,30]],"date-time":"2020-06-30T00:00:00Z","timestamp":1593475200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Surgical excision is the preferred treatment for multiple endocrine neoplasia type 1 (MEN1)-related primary hyperparathyroidism (PHPT), although controversy regarding the surgical strategy exists. We retrospectively investigated the short-term outcomes of PHPT by various surgical extents. Thirty-three patients who underwent parathyroidectomy due to MEN1-related PHPT at Yonsei Severance Hospital between 2005 and 2018 were included (age [mean\u2009\u00b1\u2009SD], 43.4\u2009\u00b1\u200914.1 [range, 23\u201381] years). Total parathyroidectomy with auto-transplantation to the forearm (TPX) was the most common surgical method (17\/33), followed by less-than-subtotal parathyroidectomy (LPX; 12\/33) and subtotal parathyroidectomy (SPX; 4\/33). There was no postoperative persistent hyperparathyroidism. Recurrence was high in the LPX group without significance (1 in TPX, 2 in SPX, and 3 in LPX,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.076). Permanent and transient hypoparathyroidism were more common in TPX (n\u2009=\u20096\/17, 35.3%,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.031; n\u2009=\u20094\/17, 23.5%,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.154, respectively). Parathyroid venous sampling (PVS) was introduced in 2013 for preoperative localisation of hyperparathyroidism at our hospital; nine among 19 patients operated on after 2013 underwent pre-parathyroidectomy PVS, with various surgical extents, and no permanent hypoparathyroidism (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.033) or post-LPX recurrence was observed. Although TPX with auto-transplantation is the standard surgery for MEN1-related PHPT, surgical extent individualisation is necessary, given the postoperative hypoparathyroidism rate of TPX and feasibility of PVS.\n                  <\/jats:p>","DOI":"10.1038\/s41598-020-67424-5","type":"journal-article","created":{"date-parts":[[2020,6,30]],"date-time":"2020-06-30T06:03:57Z","timestamp":1593497037000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Benefit of diverse surgical approach on short-term outcomes of MEN1-related hyperparathyroidism"],"prefix":"10.1038","volume":"10","author":[{"given":"Hye Ryeon","family":"Choi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sun Hyung","family":"Choi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soon Min","family":"Choi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin Kyong","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cho Rok","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sang-Wook","family":"Kang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jandee","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jong Ju","family":"Jeong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kee-Hyun","family":"Nam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Woong Youn","family":"Chung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seunghyun","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Namki","family":"Hong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yumie","family":"Rhee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2020,6,30]]},"reference":[{"key":"67424_CR1","doi-asserted-by":"publisher","first-page":"558","DOI":"10.3389\/fendo.2018.00558","volume":"9","author":"F Tonelli","year":"2018","unstructured":"Tonelli, F., Marini, F., Giusti, F. & Brandi, M. L. Total and subtotal parathyroidectomy in young patients with multiple endocrine neoplasia Type 1-related primary hyperparathyroidism potential post-surgical benefits and complications. Front Endocrinol. (Lausanne) 9, 558. https:\/\/doi.org\/10.3389\/fendo.2018.00558 (2018).","journal-title":"Front Endocrinol. (Lausanne)"},{"key":"67424_CR2","doi-asserted-by":"publisher","first-page":"2990","DOI":"10.1210\/jc.2012-1230","volume":"97","author":"RV Thakker","year":"2012","unstructured":"Thakker, R. V. et al. Clinical practice guidelines for multiple endocrine neoplasia type 1 (MEN1). J. Clin. Endocrinol. Metab. 97, 2990\u20133011. https:\/\/doi.org\/10.1210\/jc.2012-1230 (2012).","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"67424_CR3","doi-asserted-by":"publisher","first-page":"521","DOI":"10.1111\/j.1365-2265.1991.tb00938.x","volume":"35","author":"SJ Marx","year":"1991","unstructured":"Marx, S. J. et al. Heterogeneous size of the parathyroid glands in familial multiple endocrine neoplasia type 1. Clin. Endocrinol. (Oxf.) 35, 521\u2013526. https:\/\/doi.org\/10.1111\/j.1365-2265.1991.tb00938.x (1991).","journal-title":"Clin. Endocrinol. (Oxf.)"},{"key":"67424_CR4","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1097\/01.cco.0000148567.29850.31","volume":"17","author":"T Carling","year":"2005","unstructured":"Carling, T. Multiple endocrine neoplasia syndrome: genetic basis for clinical management. Curr. Opin. Oncol. 17, 7\u201312. https:\/\/doi.org\/10.1097\/01.cco.0000148567.29850.31 (2005).","journal-title":"Curr. Opin. Oncol."},{"key":"67424_CR5","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1016\/j.surg.2013.03.004","volume":"154","author":"M Versnick","year":"2013","unstructured":"Versnick, M. et al. Minimally invasive parathyroidectomy provides a conservative surgical option for multiple endocrine neoplasia type 1-primary hyperparathyroidism. Surgery 154, 101\u2013105. https:\/\/doi.org\/10.1016\/j.surg.2013.03.004 (2013).","journal-title":"Surgery"},{"key":"67424_CR6","doi-asserted-by":"publisher","first-page":"2964","DOI":"10.1007\/s00268-016-3624-9","volume":"40","author":"WP Kluijfhout","year":"2016","unstructured":"Kluijfhout, W. P. et al. Unilateral clearance for primary hyperparathyroidism in selected patients with multiple endocrine neoplasia Type 1. World J. Surg. 40, 2964\u20132969. https:\/\/doi.org\/10.1007\/s00268-016-3624-9 (2016).","journal-title":"World J. Surg."},{"key":"67424_CR7","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1016\/j.jvir.2014.09.019","volume":"26","author":"M Ginsburg","year":"2015","unstructured":"Ginsburg, M. et al. Adenoma localization for recurrent or persistent primary hyperparathyroidism using dynamic four-dimensional CT and venous sampling. J. Vasc. Interv. Radiol. 26, 79\u201386. https:\/\/doi.org\/10.1016\/j.jvir.2014.09.019 (2015).","journal-title":"J. Vasc. Interv. 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