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Concentrations of ficolin-1, ficolin-2, ficolin-3 and MBL (before chemotherapy) in serum were determined as were selected polymorphisms of the corresponding genes (<jats:italic>FCN1, FCN2, FCN3<\/jats:italic>and<jats:italic>MBL2<\/jats:italic>). The control group (C) consisted of 267 healthy unrelated individuals. Median level of ficolin-1 in patients was lower (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.000001) while median levels of ficolin-2, ficolin-3 and MBL were higher (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.000001,<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.000001 and<jats:italic>p<\/jats:italic>\u2009=\u20090.0016, respectively) compared with controls. These findings were generally associated with AML itself, however the highest MBL levels predicted higher risk of severe hospital infections (accompanied with bacteremia and\/or fungaemia) (<jats:italic>p<\/jats:italic>\u2009=\u20090.012) while the lowest ficolin-1 concentrations tended to be associated with prolonged (&gt;\u20097\u00a0days) fever (<jats:italic>p<\/jats:italic>\u2009=\u20090.026). Genotyping indicated an association of<jats:italic>G\/G<\/jats:italic>homozygosity (corresponding to<jats:italic>FCN1<\/jats:italic>gene \u2212\u2009542<jats:italic>G<\/jats:italic>\u2009&gt;\u2009<jats:italic>A<\/jats:italic>polymorphism) with malignancy [<jats:italic>p<\/jats:italic>\u2009=\u20090.004, OR\u2009=\u20092.95, 95% CI (1.41\u20136.16)]. Based on ROC analysis, ficolin-1, -2 and -3 may be considered candidate supplementary biomarkers of AML. Their high potential to differentiate between patients from non-malignant controls but also from persons suffering from other haematological cancers (multiple myeloma and lymphoma) was demonstrated.<\/jats:p>","DOI":"10.1038\/s41598-020-67516-2","type":"journal-article","created":{"date-parts":[[2020,6,29]],"date-time":"2020-06-29T10:03:01Z","timestamp":1593424981000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Associations of ficolins and mannose-binding lectin with acute myeloid leukaemia in adults"],"prefix":"10.1038","volume":"10","author":[{"given":"Anna","family":"Soko\u0142owska","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna S.","family":"\u015awierzko","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gabriela","family":"Gajek","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aleksandra","family":"Go\u0142os","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mateusz","family":"Michalski","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mateusz","family":"Nowicki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Agnieszka","family":"Szala-Po\u017adziej","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna","family":"Wolska-Washer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Olga","family":"Brzezi\u0144ska","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Agnieszka","family":"Wierzbowska","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Krzysztof","family":"Jamroziak","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marek L.","family":"Kowalski","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Steffen","family":"Thiel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Misao","family":"Matsushita","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jens C.","family":"Jensenius","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maciej","family":"Cedzy\u0144ski","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2020,6,29]]},"reference":[{"key":"67516_CR1","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.achaem.2013.02.007","volume":"44","author":"A Wierzbowska","year":"2013","unstructured":"Wierzbowska, A. & Czemerska, M. 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