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A total of 100 patients undergoing arthroscopic shoulder surgery were enrolled. The patients were randomly divided into the 2\u00a0mg and 4\u00a0mg groups. The laboratory coagulation test and thromboelastographic analysis were performed before and 15\u00a0min after administering sugammadex. Prothrombin time (PT) was significantly prolonged after sugammadex administration than before it in intragroup comparisons of the 2\u00a0mg group (12.8\u2009\u00b1\u20090.6\u00a0s vs. 13.6\u2009\u00b1\u20090.7\u00a0s, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001) and the 4\u00a0mg group (13.0\u2009\u00b1\u20090.5\u00a0s vs. 13.7\u2009\u00b1\u20090.5\u00a0s, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). R time, derived from thromboelastography, was also significantly prolonged after sugammadex administration (4.7\u2009\u00b1\u20091.8\u00a0min vs. 5.8\u2009\u00b1\u20092.1\u00a0min, <jats:italic>p<\/jats:italic>\u2009=\u20090.005). In conclusion, the conventional doses of 2 or 4\u00a0mg\/kg sugammadex prolonged PT. Sugammadex 4\u00a0mg\/kg also prolonged R time, although the value was within the normal range. Therefore, physicians should be cautious with the higher sugammadex dose, particularly in patients with a high risk of bleeding because the higher dose was associated with less coagulation.<\/jats:p><jats:p><jats:bold>Trial registration<\/jats:bold>: KCT0002133 (<jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"https:\/\/cris.nih.go.kr\">https:\/\/cris.nih.go.kr<\/jats:ext-link>).<\/jats:p>","DOI":"10.1038\/s41598-020-68164-2","type":"journal-article","created":{"date-parts":[[2020,7,7]],"date-time":"2020-07-07T10:04:08Z","timestamp":1594116248000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Assessment of the effects of sugammadex on coagulation profiles using thromboelastographic parameters"],"prefix":"10.1038","volume":"10","author":[{"given":"Woon-Seok","family":"Kang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hoyoung","family":"Lim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Byung-Soo","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yeaji","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0423-3616","authenticated-orcid":false,"given":"Kyung-Don","family":"Hahm","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7764-9818","authenticated-orcid":false,"given":"Seong-Hyop","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2020,7,7]]},"reference":[{"key":"68164_CR1","doi-asserted-by":"publisher","first-page":"816","DOI":"10.1097\/ALN.0b013e31818a3fee","volume":"109","author":"RK Jones","year":"2008","unstructured":"Jones, R. K., Caldwell, J. E., Brull, S. J. & Soto, R. G. Reversal of profound rocuronium-induced blockade with sugammadex: a randomized comparison with neostigmine. Anesthesiology 109, 816\u2013824 (2008).","journal-title":"Anesthesiology"},{"key":"68164_CR2","doi-asserted-by":"publisher","first-page":"874","DOI":"10.1097\/EJA.0b013e32833d56b7","volume":"27","author":"M Blobner","year":"2010","unstructured":"Blobner, M. et al. Reversal of rocuronium-induced neuromuscular blockade with sugammadex compared with neostigmine during sevoflurane anaesthesia: results of a randomised, controlled trial. Eur. J. Anaesthesiol. 27, 874\u2013881 (2010).","journal-title":"Eur. J. Anaesthesiol."},{"key":"68164_CR3","doi-asserted-by":"publisher","first-page":"1505","DOI":"10.1213\/ANE.0000000000002562","volume":"126","author":"Y Miyazaki","year":"2018","unstructured":"Miyazaki, Y. et al. Incidence of anaphylaxis associated with sugammadex. Anesth. Analg. 126, 1505\u20131508 (2018).","journal-title":"Anesth. 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