{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T22:55:58Z","timestamp":1788389758685,"version":"build-2803163510"},"reference-count":36,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2020,7,14]],"date-time":"2020-07-14T00:00:00Z","timestamp":1594684800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2020,7,14]],"date-time":"2020-07-14T00:00:00Z","timestamp":1594684800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81571121"],"award-info":[{"award-number":["81571121"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["U54 HG007963"],"award-info":[{"award-number":["U54 HG007963"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007806","name":"Partners Healthcare","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007806","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Risk of intracranial aneurysm rupture could be affected by geometric features of intracranial aneurysms and the surrounding vasculature in a location specific manner. Our goal is to investigate the morphological characteristics associated with ruptured posterior communicating artery (PCoA) aneurysms, as well as patient factors associated with the morphological parameters.\nThree-dimensional morphological parameters in 409 patients with 432 PCoA aneurysms diagnosed at the Brigham and Women\u2019s Hospital and Massachusetts General Hospital between 1990 and 2016 who had available CT angiography (CTA) or digital subtraction angiography (DSA) were evaluated. Morphological parameters examined included aneurysm wall irregularity, presence of a daughter dome, presence of hypoplastic or aplastic A1 arteries and hypoplastic or fetal PCoA, perpendicular height, width, neck diameter, aspect and size ratio, height\/width ratio, and diameters and angles of surrounding parent and daughter vessels. Univariable and multivariable statistical analyses were performed to determine the association of morphological parameters with rupture of PCoA aneurysms. Additional analyses were performed to determine the association of patient factors with the morphological parameters. Irregular, multilobed PCoA aneurysms with larger height\/width ratios and larger flow angles were associated with ruptured PCoA aneurysms, whereas perpendicular height was inversely associated with rupture in a multivariable model. Older age was associated with lower aspect ratio, with a trend towards lower height\/width ratio and smaller flow angle, features that are associated with a lower rupture risk. Morphological parameters are easy to assess and could help in risk stratification in patients with unruptured PCoA aneurysms. PCoA aneurysms diagnosed at older age have morphological features associated with lower risk.<\/jats:p>","DOI":"10.1038\/s41598-020-68276-9","type":"journal-article","created":{"date-parts":[[2020,7,14]],"date-time":"2020-07-14T10:04:51Z","timestamp":1594721091000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Age and morphology of posterior communicating artery aneurysms"],"prefix":"10.1038","volume":"10","author":[{"given":"Jian","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anil","family":"Can","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pui Man Rosalind","family":"Lai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Jr.","given":"Srinivasan","family":"Mukundan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victor M.","family":"Castro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dmitriy","family":"Dligach","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sean","family":"Finan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sheng","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vivian S.","family":"Gainer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nancy A.","family":"Shadick","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guergana","family":"Savova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shawn N.","family":"Murphy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tianxi","family":"Cai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Scott T.","family":"Weiss","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rose","family":"Du","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2020,7,14]]},"reference":[{"key":"68276_CR1","doi-asserted-by":"publisher","first-page":"626","DOI":"10.1016\/S1474-4422(11)70109-0","volume":"10","author":"MH Vlak","year":"2011","unstructured":"Vlak, M. H., Algra, A., Brandenburg, R. & Rinkel, G. J. Prevalence of unruptured intracranial aneurysms, with emphasis on sex, age, comorbidity, country, and time period: a systematic review and meta-analysis. Lancet Neurol. 10, 626\u2013636. https:\/\/doi.org\/10.1016\/S1474-4422(11)70109-0 (2011).","journal-title":"Lancet Neurol."},{"key":"68276_CR2","doi-asserted-by":"publisher","first-page":"306","DOI":"10.1016\/S0140-6736(07)60153-6","volume":"369","author":"J van Gijn","year":"2007","unstructured":"van Gijn, J., Kerr, R. S. & Rinkel, G. J. Subarachnoid haemorrhage. Lancet 369, 306\u2013318. https:\/\/doi.org\/10.1016\/S0140-6736(07)60153-6 (2007).","journal-title":"Lancet"},{"key":"68276_CR3","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1016\/S0140-6736(03)13860-3","volume":"362","author":"DO Wiebers","year":"2003","unstructured":"Wiebers, D. O. et al. Unruptured intracranial aneurysms: natural history, clinical outcome, and risks of surgical and endovascular treatment. Lancet 362, 103\u2013110 (2003).","journal-title":"Lancet"},{"key":"68276_CR4","doi-asserted-by":"publisher","first-page":"2500","DOI":"10.1161\/STROKEAHA.107.482471","volume":"38","author":"MS Alnaes","year":"2007","unstructured":"Alnaes, M. S. et al. Computation of hemodynamics in the circle of Willis. Stroke 38, 2500\u20132505. https:\/\/doi.org\/10.1161\/STROKEAHA.107.482471 (2007).","journal-title":"Stroke"},{"key":"68276_CR5","doi-asserted-by":"publisher","first-page":"145","DOI":"10.3174\/ajnr.A2419","volume":"32","author":"JR Cebral","year":"2011","unstructured":"Cebral, J. R., Mut, F., Weir, J. & Putman, C. Quantitative characterization of the hemodynamic environment in ruptured and unruptured brain aneurysms. AJNR Am. J. Neuroradiol. 32, 145\u2013151. https:\/\/doi.org\/10.3174\/ajnr.A2419 (2011).","journal-title":"AJNR Am. J. Neuroradiol."},{"key":"68276_CR6","doi-asserted-by":"publisher","first-page":"504","DOI":"10.3340\/jkns.2017.0101.009","volume":"60","author":"H Qin","year":"2017","unstructured":"Qin, H. et al. Morphological and hemodynamic parameters for middle cerebral artery bifurcation aneurysm rupture risk assessment. J. Korean Neurosurg. Soc. 60, 504\u2013510. https:\/\/doi.org\/10.3340\/jkns.2017.0101.009 (2017).","journal-title":"J. Korean Neurosurg. Soc."},{"key":"68276_CR7","doi-asserted-by":"publisher","first-page":"913","DOI":"10.3171\/2012.7.JNS111766","volume":"117","author":"N Lin","year":"2012","unstructured":"Lin, N. et al. Differences in simple morphological variables in ruptured and unruptured middle cerebral artery aneurysms. J. Neurosurg. 117, 913\u2013919. https:\/\/doi.org\/10.3171\/2012.7.JNS111766 (2012).","journal-title":"J. Neurosurg."},{"key":"68276_CR8","doi-asserted-by":"publisher","first-page":"602","DOI":"10.1227\/01.NEU.0000311347.35583.0C","volume":"62","author":"T Sadatomo","year":"2008","unstructured":"Sadatomo, T. et al. Morphological differences between ruptured and unruptured cases in middle cerebral artery aneurysms. Neurosurgery 62, 602\u2013609. https:\/\/doi.org\/10.1227\/01.NEU.0000311347.35583.0C (2008) (discussion 602\u2013609).","journal-title":"Neurosurgery"},{"key":"68276_CR9","doi-asserted-by":"publisher","first-page":"e0166654","DOI":"10.1371\/journal.pone.0166654","volume":"11","author":"GX Wang","year":"2016","unstructured":"Wang, G. X. et al. Risk factors for the rupture of middle cerebral artery bifurcation aneurysms using CT angiography. PLoS ONE 11, e0166654. https:\/\/doi.org\/10.1371\/journal.pone.0166654 (2016).","journal-title":"PLoS ONE"},{"key":"68276_CR10","doi-asserted-by":"publisher","first-page":"e79635","DOI":"10.1371\/journal.pone.0079635","volume":"8","author":"N Lin","year":"2013","unstructured":"Lin, N. et al. Analysis of morphological parameters to differentiate rupture status in anterior communicating artery aneurysms. PLoS ONE 8, e79635. https:\/\/doi.org\/10.1371\/journal.pone.0079635 (2013).","journal-title":"PLoS ONE"},{"key":"68276_CR11","doi-asserted-by":"publisher","first-page":"e94837","DOI":"10.1371\/journal.pone.0094837","volume":"9","author":"A Ho","year":"2014","unstructured":"Ho, A. et al. Morphological parameters associated with ruptured posterior communicating aneurysms. PLoS ONE 9, e94837. https:\/\/doi.org\/10.1371\/journal.pone.0094837 (2014).","journal-title":"PLoS ONE"},{"key":"68276_CR12","doi-asserted-by":"publisher","first-page":"1251","DOI":"10.1016\/j.wneu.2015.05.078","volume":"84","author":"A Can","year":"2015","unstructured":"Can, A. et al. Association between vascular anatomy and posterior communicating artery aneurysms. World Neurosurg. 84, 1251\u20131255. https:\/\/doi.org\/10.1016\/j.wneu.2015.05.078 (2015).","journal-title":"World Neurosurg."},{"key":"68276_CR13","doi-asserted-by":"publisher","first-page":"e110946","DOI":"10.1371\/journal.pone.0110946","volume":"9","author":"AL Ho","year":"2014","unstructured":"Ho, A. L., Mouminah, A. & Du, R. Posterior cerebral artery angle and the rupture of basilar tip aneurysms. PLoS ONE 9, e110946. https:\/\/doi.org\/10.1371\/journal.pone.0110946 (2014).","journal-title":"PLoS ONE"},{"key":"68276_CR14","doi-asserted-by":"publisher","first-page":"721","DOI":"10.1227\/NEU.0000000000000713","volume":"76","author":"A Can","year":"2015","unstructured":"Can, A., Ho, A. L., Dammers, R., Dirven, C. M. & Du, R. Morphological parameters associated with middle cerebral artery aneurysms. Neurosurgery 76, 721\u2013726. https:\/\/doi.org\/10.1227\/NEU.0000000000000713 (2015) (discussion 726\u2013727).","journal-title":"Neurosurgery"},{"key":"68276_CR15","doi-asserted-by":"publisher","first-page":"62","DOI":"10.1227\/NEU.0000000000000564","volume":"76","author":"A Can","year":"2015","unstructured":"Can, A., Mouminah, A., Ho, A. L. & Du, R. Effect of vascular anatomy on the formation of basilar tip aneurysms. Neurosurgery 76, 62\u201366. https:\/\/doi.org\/10.1227\/NEU.0000000000000564 (2015) (discussion 66).","journal-title":"Neurosurgery"},{"key":"68276_CR16","doi-asserted-by":"publisher","first-page":"164","DOI":"10.1212\/WNL.0000000000003490","volume":"88","author":"VM Castro","year":"2017","unstructured":"Castro, V. M. et al. Large-scale identification of patients with cerebral aneurysms using natural language processing. Neurology 88, 164\u2013168. https:\/\/doi.org\/10.1212\/WNL.0000000000003490 (2017).","journal-title":"Neurology"},{"key":"68276_CR17","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1093\/neuros\/nyy213","volume":"85","author":"J Zhang","year":"2019","unstructured":"Zhang, J. et al. Morphological variables associated with ruptured middle cerebral artery aneurysms. Neurosurgery 85, 75\u201383. https:\/\/doi.org\/10.1093\/neuros\/nyy213 (2019).","journal-title":"Neurosurgery"},{"key":"68276_CR18","doi-asserted-by":"publisher","first-page":"194","DOI":"10.1007\/s10278-014-9733-9","volume":"28","author":"SN Murphy","year":"2015","unstructured":"Murphy, S. N. et al. High throughput tools to access images from clinical archives for research. J. Digit. Imaging 28, 194\u2013204. https:\/\/doi.org\/10.1007\/s10278-014-9733-9 (2015).","journal-title":"J. Digit. Imaging"},{"key":"68276_CR19","doi-asserted-by":"publisher","first-page":"755","DOI":"10.1007\/s002340050679","volume":"40","author":"GJ Hademenos","year":"1998","unstructured":"Hademenos, G. J., Massoud, T. F., Turjman, F. & Sayre, J. W. Anatomical and morphological factors correlating with rupture of intracranial aneurysms in patients referred for endovascular treatment. Neuroradiology 40, 755\u2013760 (1998).","journal-title":"Neuroradiology"},{"key":"68276_CR20","doi-asserted-by":"publisher","first-page":"861","DOI":"10.1007\/s00701-003-0124-0","volume":"145","author":"J Beck","year":"2003","unstructured":"Beck, J. et al. Difference in configuration of ruptured and unruptured intracranial aneurysms determined by biplanar digital subtraction angiography. Acta Neurochir. (Wien) 145, 861\u2013865. https:\/\/doi.org\/10.1007\/s00701-003-0124-0 (2003) (discussion 865).","journal-title":"Acta Neurochir. (Wien)"},{"key":"68276_CR21","doi-asserted-by":"publisher","first-page":"e0142330","DOI":"10.1371\/journal.pone.0142330","volume":"10","author":"H Kang","year":"2015","unstructured":"Kang, H. et al. Aneurysm characteristics associated with the rupture risk of intracranial aneurysms: a self-controlled study. PLoS ONE 10, e0142330. https:\/\/doi.org\/10.1371\/journal.pone.0142330 (2015).","journal-title":"PLoS ONE"},{"key":"68276_CR22","doi-asserted-by":"publisher","first-page":"761","DOI":"10.1136\/neurintsurg-2013-010944","volume":"6","author":"WA Mehan Jr","year":"2014","unstructured":"Mehan, W. A. Jr. et al. Unruptured intracranial aneurysms conservatively followed with serial CT angiography: could morphology and growth predict rupture?. J. Neurointerv. Surg. 6, 761\u2013766. https:\/\/doi.org\/10.1136\/neurintsurg-2013-010944 (2014).","journal-title":"J. Neurointerv. Surg."},{"key":"68276_CR23","doi-asserted-by":"publisher","first-page":"355","DOI":"10.3171\/jns.2005.102.2.0355","volume":"102","author":"ML Raghavan","year":"2005","unstructured":"Raghavan, M. L., Ma, B. & Harbaugh, R. E. Quantified aneurysm shape and rupture risk. J. Neurosurg. 102, 355\u2013362. https:\/\/doi.org\/10.3171\/jns.2005.102.2.0355 (2005).","journal-title":"J. Neurosurg."},{"key":"68276_CR24","doi-asserted-by":"publisher","first-page":"495","DOI":"10.1097\/00006123-200103000-00007","volume":"48","author":"H Ujiie","year":"2001","unstructured":"Ujiie, H., Tamano, Y., Sasaki, K. & Hori, T. Is the aspect ratio a reliable index for predicting the rupture of a saccular aneurysm?. Neurosurgery 48, 495\u2013502 (2001) (discussion 502\u2013493).","journal-title":"Neurosurgery"},{"key":"68276_CR25","doi-asserted-by":"publisher","first-page":"e0149906","DOI":"10.1371\/journal.pone.0149906","volume":"11","author":"N Lv","year":"2016","unstructured":"Lv, N. et al. Morphological and hemodynamic discriminators for rupture status in posterior communicating artery aneurysms. PLoS ONE 11, e0149906. https:\/\/doi.org\/10.1371\/journal.pone.0149906 (2016).","journal-title":"PLoS ONE"},{"key":"68276_CR26","doi-asserted-by":"publisher","first-page":"311","DOI":"10.1016\/j.wneu.2015.12.055","volume":"87","author":"N Lv","year":"2016","unstructured":"Lv, N. et al. Morphological risk factors for rupture of small (<7 mm) posterior communicating artery aneurysms. World Neurosurg. 87, 311\u2013315. https:\/\/doi.org\/10.1016\/j.wneu.2015.12.055 (2016).","journal-title":"World Neurosurg."},{"key":"68276_CR27","doi-asserted-by":"publisher","first-page":"247","DOI":"10.1177\/159101990801400304","volume":"14","author":"T Sola","year":"2008","unstructured":"Sola, T. et al. Clinical and radiological features of posterior communicating artery aneurysms. Interv. Neuroradiol. 14, 247\u2013251. https:\/\/doi.org\/10.1177\/159101990801400304 (2008).","journal-title":"Interv. Neuroradiol."},{"key":"68276_CR28","doi-asserted-by":"publisher","first-page":"104","DOI":"10.3171\/2013.9.JNS13921","volume":"120","author":"H Matsukawa","year":"2014","unstructured":"Matsukawa, H. et al. Morphological and clinical risk factors for posterior communicating artery aneurysm rupture. J. Neurosurg. 120, 104\u2013110. https:\/\/doi.org\/10.3171\/2013.9.JNS13921 (2014).","journal-title":"J. Neurosurg."},{"key":"68276_CR29","doi-asserted-by":"publisher","first-page":"459","DOI":"10.1179\/016164105X25171","volume":"27","author":"H Meng","year":"2005","unstructured":"Meng, H. et al. Mathematical model of the rupture mechanism of intracranial saccular aneurysms through daughter aneurysm formation and growth. Neurol. Res. 27, 459\u2013465. https:\/\/doi.org\/10.1179\/016164105X25171 (2005).","journal-title":"Neurol. Res."},{"key":"68276_CR30","doi-asserted-by":"publisher","first-page":"1643","DOI":"10.1007\/s00701-017-3263-4","volume":"159","author":"J Huhtakangas","year":"2017","unstructured":"Huhtakangas, J. et al. CTA analysis and assessment of morphological factors related to rupture in 413 posterior communicating artery aneurysms. Acta Neurochir. (Wien) 159, 1643\u20131652. https:\/\/doi.org\/10.1007\/s00701-017-3263-4 (2017).","journal-title":"Acta Neurochir. (Wien)"},{"key":"68276_CR31","doi-asserted-by":"publisher","first-page":"1219","DOI":"10.1161\/STROKEAHA.115.012404","volume":"47","author":"AE Lindgren","year":"2016","unstructured":"Lindgren, A. E. et al. Irregular shape of intracranial aneurysm indicates rupture risk irrespective of size in a population-based cohort. Stroke 47, 1219\u20131226. https:\/\/doi.org\/10.1161\/STROKEAHA.115.012404 (2016).","journal-title":"Stroke"},{"key":"68276_CR32","doi-asserted-by":"publisher","first-page":"871","DOI":"10.3171\/2011.11.JNS11311","volume":"116","author":"MI Baharoglu","year":"2012","unstructured":"Baharoglu, M. I., Lauric, A., Gao, B. L. & Malek, A. M. Identification of a dichotomy in morphological predictors of rupture status between sidewall- and bifurcation-type intracranial aneurysms. J. Neurosurg. 116, 871\u2013881. https:\/\/doi.org\/10.3171\/2011.11.JNS11311 (2012).","journal-title":"J. Neurosurg."},{"key":"68276_CR33","doi-asserted-by":"publisher","first-page":"716","DOI":"10.1227\/01.NEU.0000298899.77097.BF","volume":"61","author":"BL Hoh","year":"2007","unstructured":"Hoh, B. L. et al. Bottleneck factor and height-width ratio: association with ruptured aneurysms in patients with multiple cerebral aneurysms. Neurosurgery 61, 716\u2013722. https:\/\/doi.org\/10.1227\/01.NEU.0000298899.77097.BF (2007) (discussion 722\u2013713).","journal-title":"Neurosurgery"},{"key":"68276_CR34","doi-asserted-by":"publisher","first-page":"38","DOI":"10.1227\/NEU.0b013e3182503bf9","volume":"71","author":"A Lauric","year":"2012","unstructured":"Lauric, A., Baharoglu, M. I. & Malek, A. M. Ruptured status discrimination performance of aspect ratio, height\/width, and bottleneck factor is highly dependent on aneurysm sizing methodology. Neurosurgery 71, 38\u201345. https:\/\/doi.org\/10.1227\/NEU.0b013e3182503bf9 (2012).","journal-title":"Neurosurgery"},{"key":"68276_CR35","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1227\/NEU.0000000000000735","volume":"77","author":"AL Ho","year":"2015","unstructured":"Ho, A. L., Lin, N., Frerichs, K. U. & Du, R. Smoking and Intracranial Aneurysm Morphology. Neurosurgery 77, 59\u201366. https:\/\/doi.org\/10.1227\/NEU.0000000000000735 (2015) (discussion 66).","journal-title":"Neurosurgery"},{"key":"68276_CR36","doi-asserted-by":"publisher","first-page":"271582","DOI":"10.1155\/2012\/271582","volume":"2012","author":"N Chalouhi","year":"2012","unstructured":"Chalouhi, N. et al. Cigarette smoke and inflammation: role in cerebral aneurysm formation and rupture. Mediators Inflamm. 2012, 271582. https:\/\/doi.org\/10.1155\/2012\/271582 (2012).","journal-title":"Mediators Inflamm."}],"container-title":["Scientific Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41598-020-68276-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-020-68276-9","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-020-68276-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,12,6]],"date-time":"2022-12-06T13:28:18Z","timestamp":1670333298000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41598-020-68276-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,7,14]]},"references-count":36,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2020,12]]}},"alternative-id":["68276"],"URL":"https:\/\/doi.org\/10.1038\/s41598-020-68276-9","relation":{},"ISSN":["2045-2322"],"issn-type":[{"value":"2045-2322","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,7,14]]},"assertion":[{"value":"19 November 2019","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"25 February 2020","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 July 2020","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"11545"}}