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Following CRE\/TAU mixture administration in the <jats:italic>Drosophila<\/jats:italic> model, depression-like state induced by vibration, locomotion, climbing activity, and survival rate were measured. The normal stress (NS) group demonstrated decreased movement than the control (CON) group; movements in the CRE\/TAU-treated group (particularly 0.15\/0.5%) returned to the CON levels. Antidepressant effects of CRE\/TAU mixtures were confirmed in a depressive mouse model induced by chronic mild stress. In behavioural assessments, movement and sucrose preference of the CRE\/TAU group increased to a similar level as in the positive control group; hippocampal catecholamine and serotonin levels increased significantly. Stress-related hormones (adrenocorticotropic and corticotropin-releasing hormones) and inflammatory factors (IL-1\u03b2, IL-6, and TNF-\u03b1) increased in the NS group but significantly decreased in the CRE\/TAU-treated group. Brain signalling protein expression ratio of phosphorylated protein kinase B (p-Akt)\/Akt, phosphorylated extracellular signal-regulated kinase (p-ERK)\/ERK, and brain-derived neurotrophic factor (BDNF) significantly increased in the CRE\/TAU-treated group. These results indicate that CRE\/TAU-induced antidepressant effects are associated with increased behavioural patterns and downregulation of stress hormones and cytokines, mediated through Akt and ERK\/BDNF pathways in vertebrate models.<\/jats:p>","DOI":"10.1038\/s41598-020-68424-1","type":"journal-article","created":{"date-parts":[[2020,7,9]],"date-time":"2020-07-09T10:06:38Z","timestamp":1594289198000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Creatine and taurine mixtures alleviate depressive-like behaviour in Drosophila melanogaster and mice via regulating Akt and ERK\/BDNF pathways"],"prefix":"10.1038","volume":"10","author":[{"given":"Suhyeon","family":"Kim","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ki-Bae","family":"Hong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Singeun","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyung Joo","family":"Suh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyungae","family":"Jo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2020,7,9]]},"reference":[{"key":"68424_CR1","doi-asserted-by":"publisher","first-page":"407","DOI":"10.1016\/j.genhosppsych.2008.05.001","volume":"30","author":"SB Patten","year":"2008","unstructured":"Patten, S. 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