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Aim of the present study was to report results of antireflux surgery in neurologically impaired children. A retrospective study of neurologically impaired children who underwent fundoplication over a 13-year period (1999\u20132012) was performed. Recurrence rate, major complications and parents\/caregivers perceptions of their child's quality of life following antireflux surgery were analyzed. A total of 122 children (median age: 8\u00a0years 9\u00a0months; range: 3\u00a0months to 18\u00a0years) had open \u201ctension-free\u201d Nissen fundoplication, gastrostomy\u2009+\u2009\/\u2212 pyloroplasty. Gastroesophageal reflux disease was in all cases documented by at least two diagnostic exams. Median duration of follow-up was 9.7 (1.9\u201313) years. Three (2.4%) recurrences were documented and required surgery re-do. Major complications were 6%. Seventy-nine of 87 (90%) caregivers reported that weight gain was improved after fundoplication with a median score of 1 (IQR: 1\u20132). Significant improvement was perceived in postoperative overall quality of life. In this series of fundoplication recurrence incidence was low, serious complications were uncommon and caregivers\u2019 satisfaction with surgery was high. Accurate patient\u2019s selection and creating a \u201clow-pressure\u201d surgical system are mandatory to obtain these results.<\/jats:p>","DOI":"10.1038\/s41598-020-68595-x","type":"journal-article","created":{"date-parts":[[2020,7,15]],"date-time":"2020-07-15T10:04:02Z","timestamp":1594807442000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Nissen fundoplication and combined procedures to reduce recurrence of gastroesophageal reflux disease in neurologically impaired children"],"prefix":"10.1038","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9782-2219","authenticated-orcid":false,"given":"Emanuela","family":"Ceriati","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Marchetti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Caccamo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"O.","family":"Adorisio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"Rivosecchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"De Peppo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2020,7,15]]},"reference":[{"key":"68595_CR1","doi-asserted-by":"publisher","first-page":"222","DOI":"10.1136\/archdischild-2011-300914","volume":"97","author":"MJ Andrew","year":"2012","unstructured":"Andrew, M. 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