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The purpose of this study is to examine the effects of low energy narrow-range UV-LED on osteosarcopenia in animal models of senescence-accelerated mouse prone 6 (SAMP6). Preliminary experiments specified the minimum irradiance intensity and dose efficacy for vitamin D production (316\u00a0nm, 0.16\u00a0mW\/cm<jats:sup>2<\/jats:sup>, 1,000\u00a0J\/m<jats:sup>2<\/jats:sup>). we set a total of 4 groups (n\u2009=\u20098 per group); vitamin D-repletion without UV irradiation (Vit.D+UV\u2212), vitamin D-repletion with UV irradiation (Vit.D+UV\u2009+), vitamin D-deficiency without UV irradiation, (Vit.D\u2212UV\u2212), and vitamin D-deficiency with UV irradiation (Vit.D\u2212UV\u2009+). Serum levels of 25(OH)D at 28 and 36\u00a0weeks of age were increased in Vit.D\u2212UV+ group as compared with Vit.D\u2212UV\u2212\u2009group. Trabecular bone mineral density on micro-CT was higher in Vit.D\u2212UV+ group than in Vit.D\u2212UV\u2212 group at 36\u00a0weeks of age. In the histological assay, fewer osteoclasts were observed in Vit.D\u2212UV+ group than in Vit.D\u2212UV\u2212 group. Grip strength and muscle mass were higher in Vit.D\u2212UV+ group than in Vit.D\u2212UV\u2212 group at 36\u00a0weeks of age. Signs of severe damage induced by UV irradiation was not found in skin histology. Low energy narrow-range UV irradiation may improve osteosarcopenia associated with vitamin D deficiency in SAMP6.<\/jats:p>","DOI":"10.1038\/s41598-020-68641-8","type":"journal-article","created":{"date-parts":[[2020,7,17]],"date-time":"2020-07-17T14:23:54Z","timestamp":1594995834000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Low energy irradiation of narrow-range UV-LED prevents osteosarcopenia associated with vitamin D deficiency in senescence-accelerated mouse prone 6"],"prefix":"10.1038","volume":"10","author":[{"given":"Kazuya","family":"Makida","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshihiro","family":"Nishida","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daigo","family":"Morita","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satoshi","family":"Ochiai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshitoshi","family":"Higuchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taisuke","family":"Seki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kunihiro","family":"Ikuta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naoki","family":"Ishiguro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2020,7,17]]},"reference":[{"key":"68641_CR1","doi-asserted-by":"publisher","first-page":"2781","DOI":"10.1007\/s00198-017-4151-8","volume":"28","author":"HP Hirschfeld","year":"2017","unstructured":"Hirschfeld, H. 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