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In this study, we conducted a cross-sectional survey in 10 villages located along the Lalin River in northeast China. Clonorchiasis was diagnosed using a modified Kato\u2013Katz method that detects the <jats:italic>C. sinensis<\/jats:italic> egg in stools. A total of 3,068 persons were screened and 2,911 were recruited for the study. Overall, the prevalence of <jats:italic>C. sinensis<\/jats:italic> infection was 29.3%. Among 175 participants who were cured after antiparasitic treatment, 54 (30.86%) were re-infected in this survey. After calibration of potential confounders, male gender, occupation as a farmer, smoking, and occasionally or frequently eating raw fish were independent risk factors for <jats:italic>C. sinensis<\/jats:italic> infection. The results of laboratory examinations in the <jats:italic>C. sinensis<\/jats:italic>\/hepatitis B or C virus co-infection group were similar to those in the hepatitis B or C virus mono-infection groups. In conclusion, <jats:italic>C. sinensis<\/jats:italic> is highly endemic in villages along the Lalin River, and the primary route of infection is the consumption of raw freshwater fish. Co-infection with <jats:italic>C. sinensis<\/jats:italic> did't aggravate the clinical manifestations of viral hepatitis in this cross-sectional study.<\/jats:p>","DOI":"10.1038\/s41598-020-68684-x","type":"journal-article","created":{"date-parts":[[2020,7,16]],"date-time":"2020-07-16T10:02:53Z","timestamp":1594893773000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["High prevalence of Clonorchis sinensis infections and coinfection with hepatitis virus in riverside villages in northeast 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