{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T18:43:29Z","timestamp":1787510609906,"version":"build-2736575974"},"reference-count":48,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2020,7,17]],"date-time":"2020-07-17T00:00:00Z","timestamp":1594944000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2020,7,17]],"date-time":"2020-07-17T00:00:00Z","timestamp":1594944000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"EC | Horizon 2020 Framework Programme","award":["641805"],"award-info":[{"award-number":["641805"]}]},{"DOI":"10.13039\/501100003554","name":"Lundbeckfonden","doi-asserted-by":"crossref","award":["R186-2015-2138"],"award-info":[{"award-number":["R186-2015-2138"]}],"id":[{"id":"10.13039\/501100003554","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Biomarkers suitable for early diagnosis and monitoring disease progression are the cornerstone of developing disease-modifying treatments for neurodegenerative diseases such as Parkinson\u2019s disease (PD). Besides motor complications, PD is also characterized by deficits in visual processing. Here, we investigate how virally-mediated overexpression of \u03b1-synuclein in the\n                    <jats:italic>substantia nigra pars compacta<\/jats:italic>\n                    impacts visual processing in a well-established rodent model of PD. After a unilateral injection of vector, human \u03b1-synuclein was detected in the striatum and superior colliculus (SC). In parallel, there was a significant delay in the latency of the transient VEPs from the affected side of the SC in late stages of the disease. Inhibition of leucine-rich repeat kinase using PFE360 failed to rescue the VEP delay and instead\n                    <jats:italic>increased<\/jats:italic>\n                    the latency of the VEP waveform. A support vector machine classifier accurately classified rats according to their `disease state\u2019 using frequency-domain data from steady-state visual evoked potentials (SSVEP). Overall, these findings indicate that the latency of the rodent VEP is sensitive to changes mediated by the increased expression of \u03b1-synuclein and especially when full overexpression is obtained, whereas the SSVEP facilitated detection of \u03b1-synuclein across reflects all stages of PD model progression.\n                  <\/jats:p>","DOI":"10.1038\/s41598-020-68808-3","type":"journal-article","created":{"date-parts":[[2020,7,17]],"date-time":"2020-07-17T10:23:54Z","timestamp":1594981434000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Classification of\u00a0\u03b1-synuclein-induced changes\u00a0in the AAV \u03b1-synuclein rat model of Parkinson\u2019s disease using electrophysiological measurements of visual processing"],"prefix":"10.1038","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7113-1743","authenticated-orcid":false,"given":"Freja Gam","family":"\u00d8stergaard","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc M.","family":"Himmelberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bettina","family":"Laursen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hartwig R.","family":"Siebner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alex R.","family":"Wade","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenneth Vielsted","family":"Christensen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2020,7,17]]},"reference":[{"key":"68808_CR1","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1136\/bmj.39289.437454.AD","volume":"335","author":"CE Clarke","year":"2007","unstructured":"Clarke, C. 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