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All syphilis-infected pregnant women registered in the Information System of Prevention of Mother-to-Child Transmission of Syphilis Management (IPMTCT) in Hunan between January 2015 and December 2018 were included in this study. Among 9,059 pregnant women with syphilis, 7,797 received syphilis treatment, with a treatment rate of 86.1%, and 4,963 underwent standardized syphilis treatment, with an average standardized treatment rate of 54.8%. The facilitators for the standardized treatment included abnormal reproductive histories (aOR\u2009=\u20091.15, 95%CI:1.03\u20131.28), time of first prenatal care within 1\u201312\u00a0weeks (aOR\u2009=\u20095.17, 95%CI:4.19\u20136.37) or within 13\u201327\u00a0weeks (aOR\u2009=\u20095.56, 95%CI:4.46\u20136.92), previous syphilis infection (aOR\u2009=\u20091.64, 95%CI: 1.48\u20131.81), and definite syphilis infection status of sexual partner (negative: aOR\u2009=\u20091.73, 95%CI:1.57\u20131.91; positive: aOR\u2009=\u20091.62, 95%CI:1.34\u20131.95). The barriers included marital status being unmarried\/divorced\/widowed (aOR\u2009=\u20090.81, 95%CI: 0.65\u20130.99), pluripara (aOR\u2009=\u20090.58, 95%CI: 0.46\u20130.74), number of children\u2009\u2265\u20092 (aOR\u2009=\u20090.45, 95%CI: 0.35\u20130.57), and syphilis clinical stage being primary\/secondary\/tertiary (aOR\u2009=\u20090.72, 95%CI: 0.58\u20130.88) or unclear (aOR\u2009=\u20090.78, 95%CI: 0.70\u20130.86). Though the treatment rate of syphilis-infected pregnant women was high, the standardized treatment rate was low. The facilitators and barriers on standardized treatment of gestational syphilis were identified at the patient level.<\/jats:p>","DOI":"10.1038\/s41598-020-69070-3","type":"journal-article","created":{"date-parts":[[2020,7,21]],"date-time":"2020-07-21T10:02:52Z","timestamp":1595325772000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Standardized treatment and determinants on 9,059 syphilis-infected pregnant women during 2015\u20132018 in Hunan, China"],"prefix":"10.1038","volume":"10","author":[{"given":"Huixia","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingjing","family":"Tan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhongwen","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianfei","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guangwen","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan","family":"Xiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qun","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Na","family":"Feng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2020,7,21]]},"reference":[{"key":"69070_CR1","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1097\/OLQ.0b013e3181b3915b","volume":"37","author":"FC Hong","year":"2010","unstructured":"Hong, F. 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