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Thus, in this work nano-SnO<jats:sub>2<\/jats:sub> was used to develop a new <jats:sup>68<\/jats:sup>Ge\/<jats:sup>68<\/jats:sup>Ga generator which was evaluated over a period of 17\u00a0months and 305 elution cycles. The elution yield was 91.1\u2009\u00b1\u20091.8% in the first 7\u00a0mL (1\u00a0M HCl as eluent) when the generator was new and then it decreased with time and use to 73.8\u2009\u00b1\u20091.9%. Around 80% of the elutable <jats:sup>68<\/jats:sup>Ga activity was obtained in 1\u00a0mL and the <jats:sup>68<\/jats:sup>Ge content in the eluate did not exceed 1\u2009\u00d7\u200910<jats:sup>\u20134<\/jats:sup>% over the investigation period when it was eluted regularly. The described generator provided adequate results for radiolabelling of DOTA-TOC with direct use of eluate. In addition, [<jats:sup>68<\/jats:sup>Ga]Ga-DOTA-TOC was tested satisfactorily for in vivo tumor detection by microPET\/CT imaging in a lung cancer mouse model.<\/jats:p>","DOI":"10.1038\/s41598-020-69659-8","type":"journal-article","created":{"date-parts":[[2020,7,29]],"date-time":"2020-07-29T10:04:12Z","timestamp":1596017052000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Development and long-term evaluation of a new 68Ge\/68Ga generator based on nano-SnO2 for PET imaging"],"prefix":"10.1038","volume":"10","author":[{"given":"Eduardo","family":"Romero","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alfonso","family":"Mart\u00ednez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marta","family":"Oteo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marta","family":"Iba\u00f1ez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mirentxu","family":"Santos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1984-5834","authenticated-orcid":false,"given":"Miguel \u00c1ngel","family":"Morcillo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2020,7,29]]},"reference":[{"key":"69659_CR1","doi-asserted-by":"publisher","first-page":"122","DOI":"10.1016\/j.apradiso.2013.11.082","volume":"87","author":"E Garc\u00eda-Tora\u00f1o","year":"2014","unstructured":"Garc\u00eda-Tora\u00f1o, E., Peyr\u00e9s, V., Romero, E. & Roteta, M. 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