{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,31]],"date-time":"2025-12-31T04:09:07Z","timestamp":1767154147794,"version":"build-2238731810"},"reference-count":32,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2020,7,30]],"date-time":"2020-07-30T00:00:00Z","timestamp":1596067200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2020,7,30]],"date-time":"2020-07-30T00:00:00Z","timestamp":1596067200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"Korea Health Technology R"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Antenatal magnesium sulfate (MgSO\n                    <jats:sub>4<\/jats:sub>\n                    ) treatment is widely used for fetal neuroprotection in women at risk of preterm delivery. However, some studies have recently suggested that in utero MgSO\n                    <jats:sub>4<\/jats:sub>\n                    exposure is associated with an increased risk of necrotizing enterocolitis (NEC). This study aimed to investigate the association between antenatal MgSO\n                    <jats:sub>4<\/jats:sub>\n                    treatment and risk of NEC. This retrospective cohort study included 756 infants born at 24\u201331 weeks\u2019 gestation. Subjects were classified into three groups: period 1, when MgSO\n                    <jats:sub>4<\/jats:sub>\n                    treatment protocol for fetal neuroprotection was not adopted (n\u00a0=\u00a0267); period 2, when the protocol was adopted (n = 261); and period 3, when the protocol was withdrawn because of concern of risk of NEC (n = 228). Rates of NEC (\u2265 stage 2b) were analyzed according to time period and exposure to antenatal MgSO\n                    <jats:sub>4<\/jats:sub>\n                    . Significant difference in the rate of NEC was not found across the three time periods (2.6% vs. 6.5% vs. 4.8% in periods 1, 2 and 3, respectively,\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0=\u00a00.103). The rate of NEC was comparable between the infants unexposed and exposed to antenatal MgSO\n                    <jats:sub>4<\/jats:sub>\n                    (5.1% vs. 3.6%,\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0=\u00a00.369). These results showed that antenatal MgSO\n                    <jats:sub>4<\/jats:sub>\n                    treatment was not associated with risk of NEC in our study population.\n                  <\/jats:p>","DOI":"10.1038\/s41598-020-69785-3","type":"journal-article","created":{"date-parts":[[2020,7,30]],"date-time":"2020-07-30T06:24:33Z","timestamp":1596090273000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Antenatal magnesium sulfate treatment and risk of necrotizing enterocolitis in preterm infants born at less than 32\u00a0weeks of gestation"],"prefix":"10.1038","volume":"10","author":[{"given":"Ji Young","family":"Hong","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jee Youn","family":"Hong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yun-Sun","family":"Choi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoo-Min","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ji-Hee","family":"Sung","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Suk-Joo","family":"Choi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Soo-young","family":"Oh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cheong-Rae","family":"Roh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hye Seon","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Se In","family":"Sung","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"So Yoon","family":"Ahn","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yun Sil","family":"Chang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Won Soon","family":"Park","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2020,7,30]]},"reference":[{"key":"69785_CR1","doi-asserted-by":"publisher","first-page":"178","DOI":"10.1016\/S0002-9378(25)90068-3","volume":"9","author":"EM Lazard","year":"1925","unstructured":"Lazard, E. M. A preliminary report on the intravenous use of magnesium sulphate in puerperal eclampsia. Am. J. Obstet. Gynecol. 9, 178\u2013188 (1925).","journal-title":"Am. J. Obstet. Gynecol."},{"key":"69785_CR2","doi-asserted-by":"publisher","first-page":"566","DOI":"10.1111\/j.1542-2011.2011.00121.x","volume":"56","author":"LA Hunter","year":"2011","unstructured":"Hunter, L. A. & Gibbins, K. J. Magnesium sulfate: Past, present, and future. J. Midwif. Womens Health 56, 566\u2013574. https:\/\/doi.org\/10.1111\/j.1542-2011.2011.00121.x (2011).","journal-title":"J. Midwif. Womens Health"},{"key":"69785_CR3","doi-asserted-by":"publisher","first-page":"1204","DOI":"10.1097\/01.AOG.0000263775.75185.1e","volume":"109","author":"R Mittendorf","year":"2007","unstructured":"Mittendorf, R. Magnesium sulfate tocolysis: Time to quit. Obstet. Gynecol. 109, 1204\u20131205. https:\/\/doi.org\/10.1097\/01.AOG.0000263775.75185.1e (2007).","journal-title":"Obstet. 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W., Crowther, C. A., Middleton, P., Marret, S. & Rouse, D. Magnesium sulphate for women at risk of preterm birth for neuroprotection of the fetus. Cochrane Database Syst Rev, CD004661, https:\/\/doi.org\/10.1002\/14651858.CD004661.pub3 (2009).","DOI":"10.1002\/14651858.CD004661.pub3"},{"key":"69785_CR7","doi-asserted-by":"publisher","first-page":"595","DOI":"10.1016\/j.ajog.2009.04.005","volume":"200","author":"A Conde-Agudelo","year":"2009","unstructured":"Conde-Agudelo, A. & Romero, R. Antenatal magnesium sulfate for the prevention of cerebral palsy in preterm infants less than 34 weeks\u2019 gestation: A systematic review and metaanalysis. Am. J. Obstet. Gynecol. 200, 595\u2013609. https:\/\/doi.org\/10.1016\/j.ajog.2009.04.005 (2009).","journal-title":"Am. J. Obstet. Gynecol."},{"key":"69785_CR8","doi-asserted-by":"publisher","first-page":"2084","DOI":"10.1080\/14767058.2018.1424823","volume":"32","author":"BD Garg","year":"2019","unstructured":"Garg, B. D. 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