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However, targeting oncogenic regulators of Warburg effect has always been challenging owing to the wide spectrum of roles of these molecules in multitude of cells. In this study, we present ADP-dependent glucokinase (<jats:italic>ADPGK<\/jats:italic>) as a novel glucose sensor and a potential onco-target in specifically high-proliferating cells in Burkitt\u2019s lymphoma (BL). Previously, we had shown<jats:italic>ADPGK<\/jats:italic>to play a major role in T-cell activation and induction of Warburg effect. We now report<jats:italic>ADPGK<\/jats:italic>knock-out Ramos BL cells display abated in vitro and in vivo tumour aggressiveness, via tumour-macrophage co-culture, migration and Zebrafish xenograft studies. We observed perturbed glycolysis and visibly reduced markers of Warburg effect in<jats:italic>ADPGK<\/jats:italic>knock-out cells, finally leading to apoptosis. We found repression of<jats:italic>MYC<\/jats:italic>proto-oncogene, and up to four-fold reduction in accumulated mutations in translocated<jats:italic>MYC<\/jats:italic>in knock-out cells, signifying a successful targeting of the malignancy. Further, the activation induced differentiation capability of knock-out cells was impaired, owing to the inability to cope up with increased energy demands. The effects amplified greatly upon stimulation-based proliferation, thus providing a novel Burkitt\u2019s lymphoma targeting mechanism originating from metabolic catastrophe induced in the cells by removal of<jats:italic>ADPGK<\/jats:italic>.<\/jats:p>","DOI":"10.1038\/s41598-020-70014-0","type":"journal-article","created":{"date-parts":[[2020,8,12]],"date-time":"2020-08-12T10:06:55Z","timestamp":1597226815000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["ADP-dependent glucokinase as a novel onco-target for haematological malignancies"],"prefix":"10.1038","volume":"10","author":[{"given":"Amol","family":"Tandon","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jana","family":"Birkenhagen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Deepthi","family":"Nagalla","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefan","family":"K\u00f6lker","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sven Wolfgang","family":"Sauer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2020,8,12]]},"reference":[{"key":"70014_CR1","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1016\/j.cmet.2007.10.002","volume":"7","author":"RJ DeBerardinis","year":"2008","unstructured":"DeBerardinis, R. 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