{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T15:30:12Z","timestamp":1791646212863,"version":"4.3.4"},"reference-count":34,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2020,8,14]],"date-time":"2020-08-14T00:00:00Z","timestamp":1597363200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2020,8,14]],"date-time":"2020-08-14T00:00:00Z","timestamp":1597363200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"Chair in Osteoarthritis of the University of Montreal"},{"name":"ArthroLab Inc."}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Although intra-articular corticosteroid injections (IACI) are commonly used for the treatment of knee osteoarthritis (OA), there is controversy regarding possible deleterious effects on joint structure. In this line, this study investigates the effects of IACI on the evolution of knee OA structural changes and pain. Participants for this nested case\u2013control study were from the Osteoarthritis Initiative. Knees of participants who had received an IACI and had magnetic resonance images (MRI) were named cases (n\u2009=\u200993), and each matched with one control (n\u2009=\u200993). Features assessed at the yearly visits and their changes within the follow-up period were from MRI (cartilage volume, meniscal thickness, bone marrow lesions, bone curvature, and synovial effusion size), X-ray (joint space width), and clinical (Western Ontario and McMaster Universities Osteoarthritis Index [WOMAC] pain score) data. Participants who received IACI experienced a transient and significantly greater rate of loss of the meniscal thickness (<jats:italic>p<\/jats:italic>\u2009=\u20090.006) and joint space width (<jats:italic>p<\/jats:italic>\u2009=\u20090.011) in the knee medial compartment in the year they received the injection, compared to controls. No significant effect of the IACI was found on the rate of cartilage loss nor on any other knee structural changes or WOMAC pain post-treatment. In conclusion, a single IACI in knee OA was shown to be safe with no negative impact on structural changes, but there was a transient meniscal thickness reduction, a phenomenon for which the clinical relevance is at present unknown.<\/jats:p>","DOI":"10.1038\/s41598-020-70064-4","type":"journal-article","created":{"date-parts":[[2020,8,14]],"date-time":"2020-08-14T12:27:09Z","timestamp":1597408029000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":28,"title":["Intra-articular corticosteroid knee injection induces a reduction in meniscal thickness with no treatment effect on cartilage volume: a case\u2013control study"],"prefix":"10.1038","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9930-6453","authenticated-orcid":false,"given":"Jean-Pierre","family":"Pelletier","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Pierre","family":"Raynauld","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fran\u00e7ois","family":"Abram","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc","family":"Dorais","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrice","family":"Paiement","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johanne","family":"Martel-Pelletier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2020,8,14]]},"reference":[{"key":"70064_CR1","doi-asserted-by":"publisher","DOI":"10.1016\/j.semarthrit.2019.04.008","author":"O Bruyere","year":"2019","unstructured":"Bruyere, O. et al. An updated algorithm recommendation for the management of knee osteoarthritis from the European Society for Clinical and Economic Aspects of Osteoporosis, Osteoarthritis and Musculoskeletal Diseases (ESCEO). Semin. Arthritis Rheum. https:\/\/doi.org\/10.1016\/j.semarthrit.2019.04.008 (2019).","journal-title":"Semin. Arthritis Rheum."},{"key":"70064_CR2","doi-asserted-by":"publisher","first-page":"S3","DOI":"10.1016\/j.semarthrit.2015.11.010","volume":"45","author":"O Bruyere","year":"2016","unstructured":"Bruyere, O. et al. A consensus statement on the European Society for Clinical and Economic Aspects of Osteoporosis and Osteoarthritis (ESCEO) algorithm for the management of knee osteoarthritis\u2014from evidence-based medicine to the real-life setting. Semin. Arthritis Rheum. 45, S3-11. https:\/\/doi.org\/10.1016\/j.semarthrit.2015.11.010 (2016).","journal-title":"Semin. Arthritis Rheum."},{"key":"70064_CR3","doi-asserted-by":"publisher","first-page":"363","DOI":"10.1016\/j.joca.2014.01.003","volume":"22","author":"TE McAlindon","year":"2014","unstructured":"McAlindon, T. E. et al. OARSI guidelines for the non-surgical management of knee osteoarthritis. Osteoarthr. Cartil. 22, 363\u2013388. https:\/\/doi.org\/10.1016\/j.joca.2014.01.003 (2014).","journal-title":"Osteoarthr. Cartil."},{"key":"70064_CR4","doi-asserted-by":"publisher","first-page":"465","DOI":"10.1002\/acr.21596","volume":"64","author":"MC Hochberg","year":"2012","unstructured":"Hochberg, M. C. et al. American College of Rheumatology 2012 recommendations for the use of nonpharmacologic and pharmacologic therapies in osteoarthritis of the hand, hip, and knee. Arthritis Care Res. (Hoboken) 64, 465\u2013474 (2012).","journal-title":"Arthritis Care Res. (Hoboken)"},{"key":"70064_CR5","doi-asserted-by":"publisher","first-page":"1145","DOI":"10.1136\/ard.2003.011742","volume":"62","author":"KM Jordan","year":"2003","unstructured":"Jordan, K. M. et al. EULAR Recommendations 2003: an evidence based approach to the management of knee osteoarthritis: Report of a Task Force of the Standing Committee for International Clinical Studies Including Therapeutic Trials (ESCISIT). Ann. Rheum. Dis. 62, 1145\u20131155 (2003).","journal-title":"Ann. Rheum. Dis."},{"key":"70064_CR6","doi-asserted-by":"publisher","first-page":"231","DOI":"10.1177\/1759720X17729641","volume":"9","author":"M Bhandari","year":"2017","unstructured":"Bhandari, M. et al. Intra-articular hyaluronic acid in the treatment of knee osteoarthritis: a Canadian evidence-based perspective. Ther. Adv. Musculoskel. Dis. 9, 231\u2013246 (2017).","journal-title":"Ther. Adv. Musculoskel. Dis."},{"key":"70064_CR7","doi-asserted-by":"publisher","first-page":"571","DOI":"10.5435\/JAAOS-21-09-571","volume":"21","author":"DS Jevsevar","year":"2013","unstructured":"Jevsevar, D. S. Treatment of osteoarthritis of the knee: evidence-based guideline, 2nd edition. J. Am. Acad. Orthop. Surg. 21, 571\u2013576. https:\/\/doi.org\/10.5435\/JAAOS-21-09-571 (2013).","journal-title":"J. Am. Acad. Orthop. Surg."},{"key":"70064_CR8","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD005328.pub2","author":"N Bellamy","year":"2006","unstructured":"Bellamy, N. et al. Intraarticular corticosteroid for treatment of osteoarthritis of the knee. Cochrane Database Syst. Rev. https:\/\/doi.org\/10.1002\/14651858.CD005328.pub2 (2006).","journal-title":"Cochrane Database Syst. Rev."},{"key":"70064_CR9","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD005321.pub2","author":"N Bellamy","year":"2006","unstructured":"Bellamy, N. et al. Viscosupplementation for the treatment of osteoarthritis of the knee. Cochrane Database Syst. Rev. https:\/\/doi.org\/10.1002\/14651858.CD005321.pub2 (2006).","journal-title":"Cochrane Database Syst. Rev."},{"key":"70064_CR10","doi-asserted-by":"publisher","first-page":"455","DOI":"10.1007\/s40265-019-01083-3","volume":"79","author":"J Paik","year":"2019","unstructured":"Paik, J., Duggan, S. T. & Keam, S. J. Triamcinolone acetonide extended-release: a review in osteoarthritis pain of the knee. Drugs 79, 455\u2013462. https:\/\/doi.org\/10.1007\/s40265-019-01083-3 (2019).","journal-title":"Drugs"},{"key":"70064_CR11","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1007\/s40744-019-0140-z","volume":"6","author":"AI Spitzer","year":"2019","unstructured":"Spitzer, A. I. et al. Safety and efficacy of repeat administration of triamcinolone acetonide extended-release in osteoarthritis of the knee: a phase 3b, open-label study. Rheumatol. Ther. 6, 109\u2013124. https:\/\/doi.org\/10.1007\/s40744-019-0140-z (2019).","journal-title":"Rheumatol. Ther."},{"key":"70064_CR12","doi-asserted-by":"publisher","first-page":"656","DOI":"10.1148\/radiol.2019190341","volume":"293","author":"AJ Kompel","year":"2019","unstructured":"Kompel, A. J. et al. Intra-articular corticosteroid injections in the hip and knee: perhaps not as safe as we thought? Radiology 293, 656\u2013663. https:\/\/doi.org\/10.1148\/radiol.2019190341 (2019).","journal-title":"Radiology"},{"key":"70064_CR13","doi-asserted-by":"publisher","first-page":"370","DOI":"10.1002\/art.10777","volume":"48","author":"JP Raynauld","year":"2003","unstructured":"Raynauld, J. P. et al. Safety and efficacy of long-term intraarticular steroid injections in osteoarthritis of the knee: a randomized, double-blind, placebo-controlled trial. Arthritis Rheum. 48, 370\u2013377. https:\/\/doi.org\/10.1002\/art.10777 (2003).","journal-title":"Arthritis Rheum."},{"key":"70064_CR14","doi-asserted-by":"publisher","first-page":"1967","DOI":"10.1001\/jama.2017.5283","volume":"317","author":"TE McAlindon","year":"2017","unstructured":"McAlindon, T. E. et al. Effect of intra-articular triamcinolone vs saline on knee cartilage volume and pain in patients with knee osteoarthritis: a randomized clinical trial. JAMA 317, 1967\u20131975. https:\/\/doi.org\/10.1001\/jama.2017.5283 (2017).","journal-title":"JAMA"},{"key":"70064_CR15","doi-asserted-by":"publisher","first-page":"547","DOI":"10.1136\/annrheumdis-2013-203906","volume":"74","author":"J Martel-Pelletier","year":"2015","unstructured":"Martel-Pelletier, J. et al. First-line analysis of the effects of treatment on progression of structural changes in knee osteoarthritis over 24 months: data from the osteoarthritis initiative progression cohort. Ann. Rheum. Dis. 74, 547\u2013556. https:\/\/doi.org\/10.1136\/annrheumdis-2013-203906 (2015).","journal-title":"Ann. Rheum. Dis."},{"key":"70064_CR16","doi-asserted-by":"publisher","first-page":"257","DOI":"10.1016\/j.semarthrit.2015.05.001","volume":"45","author":"C Roubille","year":"2015","unstructured":"Roubille, C. et al. Impact of disease treatments on the progression of knee osteoarthritis structural changes related to meniscal extrusion: data from the OAI progression cohort. Semin. Arthritis Rheum. 45, 257\u2013267. https:\/\/doi.org\/10.1016\/j.semarthrit.2015.05.001 (2015).","journal-title":"Semin. Arthritis Rheum."},{"key":"70064_CR17","doi-asserted-by":"publisher","first-page":"1560","DOI":"10.1002\/acr.22866","volume":"68","author":"JP Raynauld","year":"2016","unstructured":"Raynauld, J. P. et al. Long-term effects of glucosamine and chondroitin sulfate on the progression of structural changes in knee osteoarthritis: six-year followup data from the osteoarthritis initiative. Arthritis Care Res. (Hoboken) 68, 1560\u20131566. https:\/\/doi.org\/10.1002\/acr.22866 (2016).","journal-title":"Arthritis Care Res. (Hoboken)"},{"key":"70064_CR18","doi-asserted-by":"publisher","first-page":"989","DOI":"10.1093\/rheumatology\/kew504","volume":"56","author":"JP Raynauld","year":"2017","unstructured":"Raynauld, J. P. et al. Bone curvature changes can predict the impact of treatment on cartilage volume loss in knee osteoarthritis: data from a 2-year clinical trial. Rheumatology (Oxford) 56, 989\u2013998. https:\/\/doi.org\/10.1093\/rheumatology\/kew504 (2017).","journal-title":"Rheumatology (Oxford)"},{"key":"70064_CR19","doi-asserted-by":"publisher","first-page":"172","DOI":"10.1186\/s13075-018-1656-2","volume":"20","author":"M Dorais","year":"2018","unstructured":"Dorais, M., Martel-Pelletier, J., Raynauld, J. P., Delorme, P. & Pelletier, J. P. Impact of oral osteoarthritis therapy usage among other risk factors on knee replacement: a nested case\u2013control study using the Osteoarthritis Initiative cohort. Arthritis Res. Ther. 20, 172. https:\/\/doi.org\/10.1186\/s13075-018-1656-2 (2018).","journal-title":"Arthritis Res. Ther."},{"key":"70064_CR20","doi-asserted-by":"publisher","first-page":"597","DOI":"10.1016\/j.joca.2015.11.003","volume":"24","author":"N Hafezi-Nejad","year":"2016","unstructured":"Hafezi-Nejad, N. et al. Long term use of analgesics and risk of osteoarthritis progressions and knee replacement: propensity score matched cohort analysis of data from the Osteoarthritis Initiative. Osteoarthr. Cartil. 24, 597\u2013604. https:\/\/doi.org\/10.1016\/j.joca.2015.11.003 (2016).","journal-title":"Osteoarthr. Cartil."},{"key":"70064_CR21","doi-asserted-by":"publisher","first-page":"724","DOI":"10.1002\/art.38933","volume":"67","author":"KL Lapane","year":"2015","unstructured":"Lapane, K. L. et al. Effects of prescription nonsteroidal antiinflammatory drugs on symptoms and disease progression among patients with knee osteoarthritis. Arthritis Rheumatol. 67, 724\u2013732. https:\/\/doi.org\/10.1002\/art.38933 (2015).","journal-title":"Arthritis Rheumatol."},{"key":"70064_CR22","unstructured":"Parsons, L. S. Performing a 1:N case-control match on propensity score. 2004. Proceedings of the Twenty-Ninth Annual SAS Users Group International Conference (SUGI 29). Montreal, Canada, Paper 165\u2013129. https:\/\/support.sas.com\/resources\/papers\/proceedings\/proceedings\/sugi129\/165-129.pdf."},{"key":"70064_CR23","doi-asserted-by":"publisher","first-page":"2699","DOI":"10.1109\/TBME.2010.2058112","volume":"57","author":"P Dodin","year":"2010","unstructured":"Dodin, P., Pelletier, J. P., Martel-Pelletier, J. & Abram, F. Automatic human knee cartilage segmentation from 3D magnetic resonance images. IEEE Trans. Biomed. Eng. 57, 2699\u20132711. https:\/\/doi.org\/10.1109\/TBME.2010.2058112 (2010).","journal-title":"IEEE Trans. Biomed. Eng."},{"key":"70064_CR24","doi-asserted-by":"publisher","first-page":"51","DOI":"10.5430\/jbgc.v3n1p51","volume":"3","author":"P Dodin","year":"2013","unstructured":"Dodin, P., Abram, F., Pelletier, J.-P. & Martel-Pelletier, J. A fully automated system for quantification of knee bone marrow lesions using MRI and the osteoarthritis initiative cohort. J. Biomed. Graph Comput. 3, 51\u201365. https:\/\/doi.org\/10.5430\/jbgc.v3n1p51 (2013).","journal-title":"J. Biomed. Graph Comput."},{"key":"70064_CR25","doi-asserted-by":"publisher","first-page":"R173","DOI":"10.1186\/ar3133","volume":"12","author":"W Li","year":"2010","unstructured":"Li, W. et al. Fully automated system for the quantification of human osteoarthritic knee joint effusion volume using magnetic resonance imaging. Arthritis Res. Ther. 12, R173. https:\/\/doi.org\/10.1186\/ar3133 (2010).","journal-title":"Arthritis Res. Ther."},{"key":"70064_CR26","doi-asserted-by":"publisher","first-page":"556","DOI":"10.1136\/ard.2004.023796","volume":"64","author":"MJ Berthiaume","year":"2005","unstructured":"Berthiaume, M. J. et al. Meniscal tear and extrusion are strongly associated with progression of symptomatic knee osteoarthritis as assessed by quantitative magnetic resonance imaging. Ann. Rheum. Dis. 64, 556\u2013563. https:\/\/doi.org\/10.1136\/ard.2004.023796 (2005).","journal-title":"Ann. Rheum. Dis."},{"key":"70064_CR27","doi-asserted-by":"publisher","first-page":"855","DOI":"10.1016\/j.joca.2019.01.007","volume":"27","author":"C Zeng","year":"2019","unstructured":"Zeng, C. et al. Intra-articular corticosteroids and the risk of knee osteoarthritis progression: results from the Osteoarthritis Initiative. Osteoarthr. Cartil. 27, 855\u2013862. https:\/\/doi.org\/10.1016\/j.joca.2019.01.007 (2019).","journal-title":"Osteoarthr. Cartil."},{"key":"70064_CR28","doi-asserted-by":"publisher","first-page":"1185","DOI":"10.1001\/jama.2017.11339","volume":"318","author":"TE McAlindon","year":"2017","unstructured":"McAlindon, T. E. & LaValley, M. P. Long-term intra-articular steroid injections and knee cartilage-reply. JAMA 318, 1185\u20131186. https:\/\/doi.org\/10.1001\/jama.2017.11339 (2017).","journal-title":"JAMA"},{"key":"70064_CR29","doi-asserted-by":"publisher","first-page":"1542","DOI":"10.1016\/j.joca.2014.04.016","volume":"22","author":"F Eckstein","year":"2014","unstructured":"Eckstein, F. et al. Trajectory of cartilage loss within 4 years of knee replacement\u2014a nested case\u2013control study from the osteoarthritis initiative. Osteoarthr. Cartil. 22, 1542\u20131549. https:\/\/doi.org\/10.1016\/j.joca.2014.04.016 (2014).","journal-title":"Osteoarthr. Cartil."},{"key":"70064_CR30","doi-asserted-by":"publisher","first-page":"707","DOI":"10.1136\/annrheumdis-2011-201164","volume":"72","author":"F Eckstein","year":"2013","unstructured":"Eckstein, F. et al. Quantitative MRI measures of cartilage predict knee replacement: a case\u2013control study from the Osteoarthritis Initiative. Ann. Rheum. Dis. 72, 707\u2013714. https:\/\/doi.org\/10.1136\/annrheumdis-2011-201164 (2013).","journal-title":"Ann. Rheum. Dis."},{"key":"70064_CR31","doi-asserted-by":"publisher","first-page":"526","DOI":"10.1053\/joca.1999.0256","volume":"7","author":"DR Gale","year":"1999","unstructured":"Gale, D. R. et al. Meniscal subluxation: association with osteoarthritis and joint space narrowing. Osteoarthr. Cartil. 7, 526\u2013532. https:\/\/doi.org\/10.1053\/joca.1999.0256\u00a0(1999).","journal-title":"Osteoarthr. Cartil."},{"key":"70064_CR32","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1038\/sj.bjp.0706736","volume":"148","author":"PJ Barnes","year":"2006","unstructured":"Barnes, P. J. How corticosteroids control inflammation: Quintiles Prize Lecture 2005. Br. J. Pharmacol. 148, 245\u2013254. https:\/\/doi.org\/10.1038\/sj.bjp.0706736 (2006).","journal-title":"Br. J. Pharmacol."},{"key":"70064_CR33","doi-asserted-by":"publisher","first-page":"481","DOI":"10.1016\/j.joca.2016.10.009","volume":"25","author":"RGC Riis","year":"2017","unstructured":"Riis, R. G. C. et al. The effects of intra-articular glucocorticoids and exercise on pain and synovitis assessed on static and dynamic magnetic resonance imaging in knee osteoarthritis: exploratory outcomes from a randomized controlled trial. Osteoarthr. Cartil. 25, 481\u2013491. https:\/\/doi.org\/10.1016\/j.joca.2016.10.009 (2017).","journal-title":"Osteoarthr. Cartil."},{"key":"70064_CR34","doi-asserted-by":"publisher","first-page":"814","DOI":"10.1016\/j.joca.2015.12.010","volume":"24","author":"C Henricsdotter","year":"2016","unstructured":"Henricsdotter, C. et al. Changes in ultrasound assessed markers of inflammation following intra-articular steroid injection combined with exercise in knee osteoarthritis: exploratory outcome from a randomized trial. Osteoarthr. Cartil. 24, 814\u2013821. https:\/\/doi.org\/10.1016\/j.joca.2015.12.010 (2016).","journal-title":"Osteoarthr. Cartil."}],"container-title":["Scientific Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41598-020-70064-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-020-70064-4","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-020-70064-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,12,6]],"date-time":"2022-12-06T17:03:36Z","timestamp":1670346216000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41598-020-70064-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,8,14]]},"references-count":34,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2020,12]]}},"alternative-id":["70064"],"URL":"https:\/\/doi.org\/10.1038\/s41598-020-70064-4","relation":{},"ISSN":["2045-2322"],"issn-type":[{"value":"2045-2322","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,8,14]]},"assertion":[{"value":"21 November 2019","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 July 2020","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 August 2020","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"This initiative was funded in part by the Chair in Osteoarthritis of the University of Montreal (Montreal, Canada) and ArthroLab Inc. (Montreal, Canada). J-P Pelletier is a shareholder in ArthroLab Inc. J-P Raynauld is a consultant for ArthroLab Inc. F Abram and P Paiement are employees of ArthroLab Inc. M Dorais is a consultant for ArthroLab Inc. J Martel-Pelletier is a shareholder in ArthroLab Inc. The other authors have no competing interests to declare. None of the authors are part of the OAI investigative team.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"13789"}}