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Single nucleotide polymorphisms (SNPs) within the <jats:italic>TLR<\/jats:italic> genes may influence host\u2013pathogen interactions and can have an impact on the progression of infectious diseases. The present study aimed to investigate the genotype distribution of <jats:italic>TLR2<\/jats:italic> (2029C\/T, rs121917864; 2258G\/A, rs5743708), <jats:italic>TLR4<\/jats:italic> (896A\/G, rs4986790), and <jats:italic>TLR9<\/jats:italic> (\u2212\u00a01237T\/C, rs5743836; \u2212\u00a01486T\/C, rs187084; 1174G\/A, rs352139; and 2848C\/T, rs352140) polymorphisms in 149 children and adolescents with infectious mononucleosis (IM) and 140 healthy individuals. The potential association of <jats:italic>TLR<\/jats:italic> SNPs with the clinical manifestations of EBV infection was also studied. The presence of <jats:italic>TLR2<\/jats:italic>, <jats:italic>TLR4<\/jats:italic>, and <jats:italic>TLR9<\/jats:italic> SNPs was identified by polymerase chain reaction\u2013restriction fragment length polymorphism (PCR\u2013RFLP). EBV DNA loads were detected by quantitative real-time PCR assay. The <jats:italic>TLR4<\/jats:italic> 896 GG and the <jats:italic>TLR9<\/jats:italic> 1174 GA genotypes were associated with an increased risk of EBV-related IM in examined patients (<jats:italic>p<\/jats:italic>\u2009=\u20090.014 and <jats:italic>p<\/jats:italic>\u2009=\u20090.001, respectively). The heterozygous genotype of the <jats:italic>TLR4<\/jats:italic> 896A\/G SNP was associated with an increased risk of elevated liver enzyme levels and leukocytosis (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05). Our preliminary study revealed that the <jats:italic>TLR4<\/jats:italic> 896A\/G and the <jats:italic>TLR9<\/jats:italic> 1174G\/A polymorphisms seem to be related to the course of acute EBV infection in children and adolescents.<\/jats:p>","DOI":"10.1038\/s41598-020-70129-4","type":"journal-article","created":{"date-parts":[[2020,8,4]],"date-time":"2020-08-04T10:04:15Z","timestamp":1596535455000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["TLR4 896A\/G and TLR9 1174G\/A polymorphisms are associated with the risk of infectious mononucleosis"],"prefix":"10.1038","volume":"10","author":[{"given":"Agnieszka","family":"Jab\u0142o\u0144ska","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miros\u0142awa","family":"Studzi\u0144ska","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leszek","family":"Szenborn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ma\u0142gorzata","family":"Wi\u015bniewska-Ligier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monika","family":"Karlikowska-Skwarnik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomasz","family":"G\u0119sicki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edyta","family":"Paradowska","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2020,8,4]]},"reference":[{"key":"70129_CR1","first-page":"364","volume":"36","author":"I Stock","year":"2013","unstructured":"Stock, I. 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