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Although the rabbit is one of the most important lab animal estrogen receptor alpha (ERA) localization on basic cells, newly discovered cells including telocyte and neuroendocrine cells, vascular compartments and interstitium during pregnancy not been described. At 0\u00a0day pregnancy, the most prominent immunoreactivity was moderate to ERA and observed on the ciliated cells, secretory cells, blood plasma, and interstitium. The smooth muscles and the endothelial cells showed mild immunoreactivity to ERA. Lymphocytes only exhibited strong immunoreactivity to ERA. At 7\u00a0days pregnancy moderate immunoreactivity to ERA observed on ciliated cells, secretory cells, smooth muscles, interstitium, and lymphocytes. Strong immunoreactivity to ERA detected on endothelial cells and blood plasma. At 14\u00a0days of pregnancy, the most prominent immunoreactivity was strong and detected on ciliated cells, smooth muscles, lymphocytes, and interstitium. Moderate immunoreactivity detected on endothelial cells and blood plasma. Secretory cells only exhibited mild immunoreactivity to ERA. At 21\u00a0days of pregnancy, the immunoreactivity to ERA ranged between mild on ciliated cells, smooth muscles, blood plasma and interstitium and negative on secretory cells, endothelial cells and lymphocytes. Our results indicated that the frequency and intensity of ERA immunostaining in the rabbit cervix varied on different structural compartments of the cervix during different pregnancy stages.<\/jats:p>","DOI":"10.1038\/s41598-020-70323-4","type":"journal-article","created":{"date-parts":[[2020,8,12]],"date-time":"2020-08-12T06:06:55Z","timestamp":1597212415000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Distribution of estrogen receptor in the rabbit cervix during pregnancy with special reference to stromal elements: an immunohistochemical study"],"prefix":"10.1038","volume":"10","author":[{"given":"Fatma El-Zahraa A.","family":"Mustafa","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruwaida","family":"Elhanbaly","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2020,8,12]]},"reference":[{"key":"70323_CR1","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/s41598-017-04759-6","volume":"7","author":"GP Wagner","year":"2017","unstructured":"Wagner, G. 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