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To our knowledge, this is the first study performing both direct measure of brain tissue pO<jats:sub>2<\/jats:sub> during acute forced exercise and underlying microvascular response at capillary and non-capillary levels. We observed that cerebral perfusion and oxygenation are enhanced during running at 5\u00a0m\/min compared to rest. At faster running speeds (10 and 15\u00a0m\/min), decreasing trends in arteriolar and capillary flow speed were observed, which could be due to cerebral autoregulation and constriction of arterioles in response to blood pressure increase. However, tissue pO<jats:sub>2<\/jats:sub> was maintained, likely due to an increase in RBC linear density. Higher cerebral oxygenation at exercise levels 5\u201315\u00a0m\/min suggests beneficial effects of exercise in situations where oxygen delivery to the brain is compromised, such as in aging, atherosclerosis and Alzheimer Disease.<\/jats:p>","DOI":"10.1038\/s41598-020-70413-3","type":"journal-article","created":{"date-parts":[[2020,8,7]],"date-time":"2020-08-07T06:03:50Z","timestamp":1596780230000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Cerebral tissue pO2 response to treadmill exercise in awake mice"],"prefix":"10.1038","volume":"10","author":[{"given":"Mohammad","family":"Moeini","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christophe","family":"Cloutier-Tremblay","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuecong","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashok","family":"Kakkar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fr\u00e9d\u00e9ric","family":"Lesage","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2020,8,7]]},"reference":[{"key":"70413_CR1","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1016\/j.pneurobio.2010.06.002","volume":"92","author":"CR Rooks","year":"2010","unstructured":"Rooks, C. 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