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We investigated cold sensitivity in CTS and its effects on surgical outcome. A search of the Swedish National Registry for Hand Surgery (HAKIR) for open carpal tunnel releases (OCTR) from 2010\u20132016 identified 10,746 cases. Symptom severity questionnaires (HQ-8; HAKIR questionnaire 8, eight Likert-scale items scored 0\u2013100, one item on cold sensitivity) and QuickDASH scores before and after surgery were collected. Patient mean age was 56\u2009\u00b1\u2009SD 16\u00a0years, and 7,150\/10,746 (67%) were women. Patients with severe cold sensitivity (defined as cold intolerance symptom severity score\u2009&gt;\u200970; n\u2009=\u2009951), scored significantly higher on QuickDASH at all time points compared to those with mild cold sensitivity (cold intolerance symptom severity scores\u2009\u2264\u200930, n\u2009=\u20091,532); preoperatively 64 [50\u201375] vs. 40 [25\u201355], at three months 32 [14\u201352] vs. 18 [9\u201332] and at 12\u00a0months 25 [7\u201350] vs. 9 [2\u201323]; all p\u2009&lt;\u20090.0001. Severe cold sensitivity predicted higher postoperative QuickDASH scores at three [12.9 points (95% CI 10.2\u201315.6; p\u2009&lt;\u20090.0001)] and at 12\u00a0months [14.8 points (11.3\u201318.4; p\u2009&lt;\u20090.0001)] compared to mild cold sensitivity, and adjustment for a concomitant condition in the hand\/arm, including ulnar nerve compression, did not influence the results. Cold sensitivity improves after OCTR. A higher preoperative degree of cold sensitivity is associated with more preoperative and postoperative disability and symptoms than a lower degree of cold sensitivity, but with the same improvement in QuickDASH score.<\/jats:p>","DOI":"10.1038\/s41598-020-70543-8","type":"journal-article","created":{"date-parts":[[2020,8,10]],"date-time":"2020-08-10T10:03:08Z","timestamp":1597053788000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Occurrence of cold sensitivity in carpal tunnel syndrome and its effects on surgical outcome following open carpal tunnel release"],"prefix":"10.1038","volume":"10","author":[{"given":"Malin","family":"Zimmerman","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erika","family":"Nyman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lars B.","family":"Dahlin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2020,8,10]]},"reference":[{"issue":"3","key":"70543_CR1","doi-asserted-by":"publisher","first-page":"308","DOI":"10.1016\/S0266-7681(97)80392-0","volume":"22","author":"MS Irwin","year":"1997","unstructured":"Irwin, M. S., Gilbert, S. E., Terenghi, G., Smith, R. W. & Green, C. J. Cold intolerance following peripheral nerve injury. Natural history and factors predicting severity of symptoms. J. Hand Surg. Br. 22(3), 308\u2013316 (1997).","journal-title":"J. Hand Surg. Br."},{"issue":"3","key":"70543_CR2","first-page":"231","volume":"5","author":"OB Cesim","year":"2019","unstructured":"Cesim, O. B. & Oksuz, C. More severe cold intolerance is associated with worse sensory function after peripheral nerve repair or decompression. J. Hand Surg. 5(3), 231\u2013236 (2019).","journal-title":"J. Hand Surg."},{"issue":"1","key":"70543_CR3","doi-asserted-by":"publisher","first-page":"148","DOI":"10.1186\/s12955-019-1215-9","volume":"17","author":"I Reitan","year":"2019","unstructured":"Reitan, I., Dahlin, L. B. & Rosberg, H. E. Patient-reported quality of life and hand disability in elderly patients after a traumatic hand injury: a retrospective study. Health Qual. 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