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Na\n                    <jats:sup>+<\/jats:sup>\n                    \/K\n                    <jats:sup>+<\/jats:sup>\n                    -ATPase has been associated with nuclear factor kappa B (NF\u03baB) signalling, a signal associated with lipopolysaccharides (LPSs)-induced immune response in connection with activated Toll-like receptor 4 (TLR4) signalling. However, the contribution of Na\n                    <jats:sup>+<\/jats:sup>\n                    \/K\n                    <jats:sup>+<\/jats:sup>\n                    -ATPase to regulating inflammatory responses remains elusive. We report that mice haploinsufficient for the astrocyte-enriched \u03b1\n                    <jats:sub>2<\/jats:sub>\n                    Na\n                    <jats:sup>+<\/jats:sup>\n                    \/K\n                    <jats:sup>+<\/jats:sup>\n                    -ATPase isoform (\u03b1\n                    <jats:sub>2<\/jats:sub>\n                    <jats:sup>+\/G301R<\/jats:sup>\n                    mice) have a reduced proinflammatory response to LPS, accompanied by a reduced hypothermic reaction compared to wild type litter mates. Following intraperitoneal injection of LPS, gene expressions of\n                    <jats:italic>Tnf-\u03b1<\/jats:italic>\n                    ,\n                    <jats:italic>Il-1\u03b2<\/jats:italic>\n                    , and\n                    <jats:italic>Il-6<\/jats:italic>\n                    was reduced in the hypothalamus and hippocampus from \u03b1\n                    <jats:sub>2<\/jats:sub>\n                    <jats:sup>+\/G301R<\/jats:sup>\n                    mice compared to \u03b1\n                    <jats:sub>2<\/jats:sub>\n                    <jats:sup>+\/+<\/jats:sup>\n                    littermates. The \u03b1\n                    <jats:sub>2<\/jats:sub>\n                    <jats:sup>+\/G301R<\/jats:sup>\n                    mice experienced increased expression of the gene encoding an antioxidant enzyme, NRF2, in hippocampal astrocytes. Our findings indicate that \u03b1\n                    <jats:sub>2<\/jats:sub>\n                    Na\n                    <jats:sup>+<\/jats:sup>\n                    \/K\n                    <jats:sup>+<\/jats:sup>\n                    -ATPase haploinsufficiency negatively modulates LPS-induced immune responses, highlighting a rational pharmacological target for reducing LPS-induced inflammation.\n                  <\/jats:p>","DOI":"10.1038\/s41598-020-71027-5","type":"journal-article","created":{"date-parts":[[2020,8,25]],"date-time":"2020-08-25T06:04:04Z","timestamp":1598335444000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["The \u03b12 Na+\/K+-ATPase isoform mediates LPS-induced neuroinflammation"],"prefix":"10.1038","volume":"10","author":[{"given":"J. A.","family":"Leite","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T. 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