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However, it is not clear that whether AID induces c-Myc\/IgH translocation in double-hit lymphoma (DHL) with c-Myc gene translocation. In this study, the AID in DHL tissues and classical diffuse large b-cell lymphoma (DLBCL) tissues were compared. The results suggested that AID is of important value in predicting DHL, stronger CSR of AID was observed in DHL patients, which exhibited AID overexpression and c-Myc gene translocation of DHL after CSR induction. It is concluded that AID directly induces CSR in DHL and may result in c-Myc gene translocation. Targeting AID may be a good treatment regimen for DHL.<\/jats:p>","DOI":"10.1038\/s41598-020-71058-y","type":"journal-article","created":{"date-parts":[[2020,8,25]],"date-time":"2020-08-25T10:04:04Z","timestamp":1598349844000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Activation-induced cytidine deaminase overexpression in double-hit lymphoma: potential target for novel anticancer therapy"],"prefix":"10.1038","volume":"10","author":[{"given":"Jingcheng","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yifen","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingzhe","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huixian","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"He","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2020,8,25]]},"reference":[{"key":"71058_CR1","doi-asserted-by":"crossref","first-page":"2760","DOI":"10.1182\/blood-2016-11-747022","volume":"129","author":"D Ennishi","year":"2017","unstructured":"Ennishi, D. et al. Genetic profiling of MYC and BCL2 in diffuse large B-cell lymphoma determines cell of origin-specific clinical impact. Blood 129, 2760\u20132770 (2017).","journal-title":"Blood"},{"key":"71058_CR2","doi-asserted-by":"crossref","first-page":"djw257","DOI":"10.1093\/jnci\/djw257","volume":"108","author":"GS Nowakowski","year":"2016","unstructured":"Nowakowski, G. S. et al. Beyond RCHOP: a blueprint for diffuse large B cell lymphoma research. J. Natl. Cancer Inst. 108, djw257 (2016).","journal-title":"J. Natl. Cancer Inst."},{"key":"71058_CR3","doi-asserted-by":"crossref","first-page":"590","DOI":"10.1182\/blood-2017-04-737320","volume":"130","author":"JW Friedberg","year":"2017","unstructured":"Friedberg, J. W. How I treat double-hit lymphoma. 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