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Previous studies related <jats:italic>T. gondii<\/jats:italic> to disorders associated with the dysfunctional dopaminergic system. However, an association between <jats:italic>T. gondii<\/jats:italic> infection and adult attention-deficit\/hyperactivity disorder (ADHD) has not yet been studied. In a sex- and age-matched case\u2013control study, we investigated the seropositivity, serointensity, and avidity of latent <jats:italic>T. gondii<\/jats:italic> infection in adult ADHD patients and examined the influence of those variables on the symptomatology of ADHD. Of 140 participants, 20.0% were seropositive for anti-<jats:italic>T. gondii<\/jats:italic> IgG and 0% for anti-<jats:italic>T. gondii<\/jats:italic> IgM. <jats:italic>T. gondii<\/jats:italic> seropositivity was associated with 2.8-fold increase in the odds of ADHD in a confounder-adjusted multivariable analysis. Age and consumption of raw\/undercooked meat were confirmed as significant predictors of <jats:italic>T. gondii<\/jats:italic> seropositivity. Multiple linear regression analysis of self-rated ADHD-related symptom severity in all participants revealed a significant association with <jats:italic>T. gondii<\/jats:italic> seropositivity, elevated IgG titers (serointensity), and stronger anti-<jats:italic>T. gondii<\/jats:italic> IgG avidity. Overall symptom severity was increased in seropositive ADHD patients compared to seronegative subjects with ADHD. In particular, hyperactivity was significantly associated with serointensity. We conclude that there is a high rate of <jats:italic>T. gondii<\/jats:italic> seropositivity in adults with ADHD. 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