{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T08:35:16Z","timestamp":1788942916691,"version":"build-2803163510"},"reference-count":48,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2020,8,28]],"date-time":"2020-08-28T00:00:00Z","timestamp":1598572800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2020,8,28]],"date-time":"2020-08-28T00:00:00Z","timestamp":1598572800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100001349","name":"National Medical Research Council, Singapore","doi-asserted-by":"crossref","award":["NMRC\/TCR\/011-NUHS\/2014"],"award-info":[{"award-number":["NMRC\/TCR\/011-NUHS\/2014"]}],"id":[{"id":"10.13039\/501100001349","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"abstract":"<jats:title>Abstract<\/jats:title><jats:p>We compared the somatostatin analog radioligand, DOTANOC, with FDG, to determine whether there was increased detection of active or sub-clinical lesions in pulmonary tuberculosis (TB) with DOTANOC. Three groups were recruited: (1) active pulmonary TB; (2) IGRA-positive household TB contacts; (3) pneumonia (non-TB). DOTANOC PET\/MRI followed by FDG PET\/MRI was performed in active TB and pneumonia groups. TB contacts underwent FDG PET\/MRI, then DOTANOC PET\/MRI if abnormalities were detected. Quantitative and qualitative analyses were performed for total lung and individual lesions. Eight active TB participants, three\u00a0TB contacts and three pneumonia patients had paired PET\/MRI scans. In the active TB group, median SUVmax<jats:sub>[FDG]<\/jats:sub> for parenchymal lesions was 7.69 (range 3.00\u201315.88); median SUVmax<jats:sub>[DOTANOC]<\/jats:sub> was 2.59 (1.48\u20136.40). Regions of tracer uptake were fairly similar for both radioligands, albeit more diffusely distributed in the FDG scans. In TB contacts, two PET\/MRIs had parenchymal lesions detected with FDG (SUVmax 5.50 and 1.82), with corresponding DOTANOC uptake &lt;\u20091. FDG and DOTANOC uptake was similar in pneumonia patients (SUVmax<jats:sub>[FDG]<\/jats:sub> 4.17\u20136.18; SUVmax<jats:sub>[DOTANOC]<\/jats:sub> 2.92\u20134.78). DOTANOC can detect pulmonary TB lesions, but FDG is more sensitive for both active and sub-clinical lesions. FDG remains the preferred ligand for clinical studies, although DOTANOC may provide additional value for pathogenesis studies.<\/jats:p>","DOI":"10.1038\/s41598-020-71127-2","type":"journal-article","created":{"date-parts":[[2020,8,28]],"date-time":"2020-08-28T10:09:48Z","timestamp":1598609388000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Comparison of 68Ga-DOTANOC with 18F-FDG using PET\/MRI imaging in patients with pulmonary tuberculosis"],"prefix":"10.1038","volume":"10","author":[{"given":"Claire M.","family":"Naftalin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesca","family":"Leek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James T. P. D.","family":"Hallinan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lih Kin","family":"Khor","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John J.","family":"Totman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yee Tang","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicholas I.","family":"Paton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2020,8,28]]},"reference":[{"key":"71127_CR1","unstructured":"World Health Organisation. Global tuberculosis report 2019. https:\/\/apps.who.int\/iris\/bitstream\/handle\/10665\/329368\/9789241565714-eng.pdf?ua=1 (2019)."},{"key":"71127_CR2","doi-asserted-by":"publisher","first-page":"971","DOI":"10.1097\/mnm.0000000000000743","volume":"38","author":"BA Thomas","year":"2017","unstructured":"Thomas, B. A. et al. A comparison of 18F-FDG PET\/MR with PET\/CT in pulmonary tuberculosis. Nucl. Med. Commun. 38, 971\u2013978. https:\/\/doi.org\/10.1097\/mnm.0000000000000743 (2017).","journal-title":"Nucl. Med. Commun."},{"key":"71127_CR3","doi-asserted-by":"publisher","first-page":"265ra166","DOI":"10.1126\/scitranslmed.3009501","volume":"6","author":"RY Chen","year":"2014","unstructured":"Chen, R. Y. et al. PET\/CT imaging correlates with treatment outcome in patients with multidrug-resistant tuberculosis. Sci. Transl. Med. 6, 265ra166. https:\/\/doi.org\/10.1126\/scitranslmed.3009501 (2014).","journal-title":"Sci. Transl. Med."},{"key":"71127_CR4","doi-asserted-by":"publisher","first-page":"1090","DOI":"10.1038\/nm.4161","volume":"22","author":"H Esmail","year":"2016","unstructured":"Esmail, H. et al. Characterization of progressive HIV-associated tuberculosis using 2-deoxy-2-[18F]fluoro-d-glucose positron emission and computed tomography. Nat. Med. 22, 1090\u20131093. https:\/\/doi.org\/10.1038\/nm.4161 (2016).","journal-title":"Nat. Med."},{"key":"71127_CR5","doi-asserted-by":"publisher","first-page":"1094","DOI":"10.1038\/nm.4177","volume":"22","author":"ST Malherbe","year":"2016","unstructured":"Malherbe, S. T. et al. Persisting positron emission tomography lesion activity and mycobacterium tuberculosis mRNA after tuberculosis cure. Nat. Med. 22, 1094\u20131100. https:\/\/doi.org\/10.1038\/nm.4177 (2016).","journal-title":"Nat. Med."},{"key":"71127_CR6","doi-asserted-by":"publisher","first-page":"2872","DOI":"10.1016\/j.ejrad.2011.09.002","volume":"81","author":"M Soussan","year":"2012","unstructured":"Soussan, M. et al. Patterns of pulmonary tuberculosis on FDG-PET\/CT. Eur. J. Radiol. 81, 2872\u20132876. https:\/\/doi.org\/10.1016\/j.ejrad.2011.09.002 (2012).","journal-title":"Eur. J. Radiol."},{"key":"71127_CR7","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-019-49057-5","author":"Y Ji","year":"2019","unstructured":"Ji, Y., Shao, C., Cui, Y., Shao, G. & Zheng, J. 18F-FDG positron-emission tomography\/computed tomography findings of radiographic lesions suggesting old healed pulmonary tuberculosis and high-risk signs of predicting recurrence: A retrospective study. Sci. Rep. https:\/\/doi.org\/10.1038\/s41598-019-49057-5 (2019).","journal-title":"Sci. Rep."},{"key":"71127_CR8","doi-asserted-by":"publisher","first-page":"287","DOI":"10.1097\/mcp.0000000000000043","volume":"20","author":"M Vorster","year":"2014","unstructured":"Vorster, M., Sathekge, M. M. & Bomanji, J. Advances in imaging of tuberculosis: The role of (1)(8)F-FDG PET and PET\/CT. Curr. Opin. Pulmonary Med. 20, 287\u2013293. https:\/\/doi.org\/10.1097\/mcp.0000000000000043 (2014).","journal-title":"Curr. Opin. Pulmonary Med."},{"key":"71127_CR9","doi-asserted-by":"publisher","first-page":"1770","DOI":"10.1007\/s00259-013-2482-z","volume":"40","author":"H Geijer","year":"2013","unstructured":"Geijer, H. & Breimer, L. H. Somatostatin receptor PET\/CT in neuroendocrine tumours: Update on systematic review and meta-analysis. Eur. J. Nuclear Med. Mol. Imaging 40, 1770\u20131780. https:\/\/doi.org\/10.1007\/s00259-013-2482-z (2013).","journal-title":"Eur. J. Nuclear Med. Mol. Imaging"},{"key":"71127_CR10","first-page":"426","volume":"4","author":"A Mojtahedi","year":"2014","unstructured":"Mojtahedi, A., Thamake, S., Tworowska, I., Ranganathan, D. & Delpassand, E. S. The value of (68)Ga-DOTATATE PET\/CT in diagnosis and management of neuroendocrine tumors compared to current FDA approved imaging modalities: A review of literature. Am. J. Nuclear Med. Molecular Imaging 4, 426\u2013434 (2014).","journal-title":"Am. J. Nuclear Med. Molecular Imaging"},{"key":"71127_CR11","doi-asserted-by":"publisher","first-page":"2112","DOI":"10.1007\/s00259-019-04398-1","volume":"46","author":"D Taieb","year":"2019","unstructured":"Taieb, D. et al. European Association of Nuclear Medicine Practice Guideline\/Society of Nuclear Medicine and Molecular Imaging Procedure Standard 2019 for radionuclide imaging of phaeochromocytoma and paraganglioma. Eur. J. Nuclear Med. Molecular Imaging 46, 2112\u20132137. https:\/\/doi.org\/10.1007\/s00259-019-04398-1 (2019).","journal-title":"Eur. J. Nuclear Med. Molecular Imaging"},{"key":"71127_CR12","doi-asserted-by":"publisher","first-page":"76","DOI":"10.1097\/mnm.0000000000000610","volume":"38","author":"K Sonmezoglu","year":"2017","unstructured":"Sonmezoglu, K. et al. The role of 68Ga-DOTA-TATE PET\/CT scanning in the evaluation of patients with multiple myeloma: Preliminary results. Nucl. Med. Commun. 38, 76\u201383. https:\/\/doi.org\/10.1097\/mnm.0000000000000610 (2017).","journal-title":"Nucl. Med. Commun."},{"key":"71127_CR13","doi-asserted-by":"publisher","first-page":"258","DOI":"10.1016\/j.remn.2015.03.003","volume":"34","author":"A Golemi","year":"2015","unstructured":"Golemi, A. et al. (68)Ga-DOTANOC PET\/CT detection of multiple extracranial localizations in a patient with anaplastic meningioma. Rev. Espanola Med. Nuclear Imagen Molecular 34, 258\u2013260. https:\/\/doi.org\/10.1016\/j.remn.2015.03.003 (2015).","journal-title":"Rev. Espanola Med. Nuclear Imagen Molecular"},{"key":"71127_CR14","doi-asserted-by":"publisher","first-page":"e132","DOI":"10.1097\/rlu.0000000000000447","volume":"40","author":"V Ambrosini","year":"2015","unstructured":"Ambrosini, V. et al. 68Ga DOTANOC PET\/CT detects primary malignant insulinoma. Clin. Nucl. Med. 40, e132-133. https:\/\/doi.org\/10.1097\/rlu.0000000000000447 (2015).","journal-title":"Clin. Nucl. Med."},{"key":"71127_CR15","doi-asserted-by":"publisher","first-page":"715","DOI":"10.1089\/thy.2013.0225","volume":"24","author":"A Versari","year":"2014","unstructured":"Versari, A. et al. Differentiated thyroid cancer: A new perspective with radiolabeled somatostatin analogues for imaging and treatment of patients. Thyroid Off. J. Am. Thyroid Assoc. 24, 715\u2013726. https:\/\/doi.org\/10.1089\/thy.2013.0225 (2014).","journal-title":"Thyroid Off. J. Am. Thyroid Assoc."},{"key":"71127_CR16","doi-asserted-by":"publisher","first-page":"E344","DOI":"10.1152\/ajpendo.00048.2003","volume":"285","author":"VA Dalm","year":"2003","unstructured":"Dalm, V. A. et al. Expression of somatostatin, cortistatin, and somatostatin receptors in human monocytes, macrophages, and dendritic cells. Am. J. Physiol. Endocrinol. Metab. 285, E344-353. https:\/\/doi.org\/10.1152\/ajpendo.00048.2003 (2003).","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"key":"71127_CR17","doi-asserted-by":"publisher","first-page":"845","DOI":"10.1189\/jlb.0606417","volume":"81","author":"C Armani","year":"2007","unstructured":"Armani, C., Catalani, E., Balbarini, A., Bagnoli, P. & Cervia, D. Expression, pharmacology, and functional role of somatostatin receptor subtypes 1 and 2 in human macrophages. J. Leukoc. Biol. 81, 845\u2013855. https:\/\/doi.org\/10.1189\/jlb.0606417 (2007).","journal-title":"J. Leukoc. Biol."},{"key":"71127_CR18","doi-asserted-by":"publisher","first-page":"943","DOI":"10.1038\/ni.1781","volume":"10","author":"DG Russell","year":"2009","unstructured":"Russell, D. G., Cardona, P. J., Kim, M. J., Allain, S. & Altare, F. Foamy macrophages and the progression of the human tuberculosis granuloma. Nat. Immunol. 10, 943\u2013948. https:\/\/doi.org\/10.1038\/ni.1781 (2009).","journal-title":"Nat. Immunol."},{"key":"71127_CR19","doi-asserted-by":"publisher","first-page":"139127","DOI":"10.1155\/2012\/139127","volume":"2012","author":"M Silva Miranda","year":"2012","unstructured":"Silva Miranda, M., Breiman, A., Allain, S., Deknuydt, F. & Altare, F. The tuberculous granuloma: An unsuccessful host defence mechanism providing a safety shelter for the bacteria?. Clin. Dev. Immunol. 2012, 139127. https:\/\/doi.org\/10.1155\/2012\/139127 (2012).","journal-title":"Clin. Dev. Immunol."},{"key":"71127_CR20","doi-asserted-by":"publisher","first-page":"497","DOI":"10.1007\/BF00173035","volume":"21","author":"PM Vanhagen","year":"1994","unstructured":"Vanhagen, P. M. et al. Somatostatin analogue scintigraphy in granulomatous diseases. Eur. J. Nucl. Med. 21, 497\u2013502 (1994).","journal-title":"Eur. J. Nucl. Med."},{"key":"71127_CR21","doi-asserted-by":"publisher","first-page":"630","DOI":"10.1046\/j.1365-2362.1999.00498.x","volume":"29","author":"AM ten Bokum","year":"1999","unstructured":"ten Bokum, A. M. et al. Immunohistochemical localization of somatostatin receptor sst2A in sarcoid granulomas. Eur. J. Clin. Investig. 29, 630\u2013636 (1999).","journal-title":"Eur. J. Clin. Investig."},{"key":"71127_CR22","doi-asserted-by":"publisher","DOI":"10.1007\/s12350-019-01782-0","author":"PE Bravo","year":"2019","unstructured":"Bravo, P. E. et al. Feasibility of somatostatin receptor-targeted imaging for detection of myocardial inflammation: A pilot study. J. Nuclear Cardiol. Off. Publ. Am. Society Nuclear Cardiol. https:\/\/doi.org\/10.1007\/s12350-019-01782-0 (2019).","journal-title":"J. Nuclear Cardiol. Off. Publ. Am. Society Nuclear Cardiol."},{"key":"71127_CR23","doi-asserted-by":"publisher","first-page":"525","DOI":"10.1136\/jclinpath-2019-205913","volume":"72","author":"L Tao","year":"2019","unstructured":"Tao, L. et al. Constant expression of somatostatin receptor 2a in minute pulmonary meningothelial-like nodules. J. Clin. Pathol. 72, 525\u2013528. https:\/\/doi.org\/10.1136\/jclinpath-2019-205913 (2019).","journal-title":"J. Clin. Pathol."},{"key":"71127_CR24","doi-asserted-by":"publisher","first-page":"216","DOI":"10.4103\/ijnm.IJNM_29_19","volume":"34","author":"A Razik","year":"2019","unstructured":"Razik, A., Singh, A. N., Roy, S. G. & Madhusudhan, K. S. Mesenteric tuberculosis masquerading as carcinoid tumor on conventional imaging and DOTANOC positron emission tomography\/computed tomography: Uncommon presentation of a common disease. Indian J. Nuclear Med. IJNM Off. J. Society Nuclear Med. India 34, 216\u2013219. https:\/\/doi.org\/10.4103\/ijnm.IJNM_29_19 (2019).","journal-title":"Indian J. Nuclear Med. IJNM Off. J. Society Nuclear Med. India"},{"key":"71127_CR25","doi-asserted-by":"publisher","first-page":"1262","DOI":"10.1097\/mnm.0000000000000206","volume":"35","author":"H Ahmadihosseini","year":"2014","unstructured":"Ahmadihosseini, H. et al. Diagnostic utility of 99mTc-EDDA-tricine-HYNIC-Tyr3-octreotate SPECT for differentiation of active from inactive pulmonary tuberculosis. Nucl. Med. Commun. 35, 1262\u20131267. https:\/\/doi.org\/10.1097\/mnm.0000000000000206 (2014).","journal-title":"Nucl. Med. Commun."},{"key":"71127_CR26","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1097\/00003072-199407000-00019","volume":"19","author":"E Ozturk","year":"1994","unstructured":"Ozturk, E. et al. The visualization of granulomatous disease with somatostatin receptor scintigraphy. Clin. Nucl. Med. 19, 129\u2013132 (1994).","journal-title":"Clin. Nucl. Med."},{"key":"71127_CR27","doi-asserted-by":"publisher","first-page":"378","DOI":"10.1590\/0100-3984.2016.0076","volume":"50","author":"PHS Monteiro","year":"2017","unstructured":"Monteiro, P. H. S. et al. SPECT\/CT with radiolabeled somatostatin analogues in the evaluation of systemic granulomatous infections. Radiol. Brasileira 50, 378\u2013382. https:\/\/doi.org\/10.1590\/0100-3984.2016.0076 (2017).","journal-title":"Radiol. Brasileira"},{"key":"71127_CR28","doi-asserted-by":"publisher","first-page":"806","DOI":"10.4049\/jimmunol.1700231","volume":"199","author":"JT Mattila","year":"2017","unstructured":"Mattila, J. T. et al. Positron emission tomography imaging of macaques with tuberculosis identifies temporal changes in granuloma glucose metabolism and integrin alpha4beta1-expressing immune cells. J. Immunol. (Baltimore, Md.: 1950) 199, 806\u2013815. https:\/\/doi.org\/10.4049\/jimmunol.1700231 (2017).","journal-title":"J. Immunol. (Baltimore, Md.: 1950)"},{"key":"71127_CR29","doi-asserted-by":"publisher","first-page":"6","DOI":"10.1186\/s13069-016-0043-3","volume":"9","author":"RM DiFazio","year":"2016","unstructured":"DiFazio, R. M. et al. Active transforming growth factor-beta is associated with phenotypic changes in granulomas after drug treatment in pulmonary tuberculosis. Fibrogenesis Tissue Repair 9, 6. https:\/\/doi.org\/10.1186\/s13069-016-0043-3 (2016).","journal-title":"Fibrogenesis Tissue Repair"},{"key":"71127_CR30","doi-asserted-by":"publisher","first-page":"122","DOI":"10.1378\/chest.09-0903","volume":"137","author":"SY Eum","year":"2010","unstructured":"Eum, S. Y. et al. Neutrophils are the predominant infected phagocytic cells in the airways of patients with active pulmonary TB. Chest 137, 122\u2013128. https:\/\/doi.org\/10.1378\/chest.09-0903 (2010).","journal-title":"Chest"},{"key":"71127_CR31","doi-asserted-by":"publisher","first-page":"1370","DOI":"10.1038\/s41385-019-0195-8","volume":"12","author":"HP Gideon","year":"2019","unstructured":"Gideon, H. P., Phuah, J., Junecko, B. A. & Mattila, J. T. Neutrophils express pro- and anti-inflammatory cytokines in granulomas from mycobacterium tuberculosis-infected cynomolgus macaques. Mucosal. Immunol. 12, 1370\u20131381. https:\/\/doi.org\/10.1038\/s41385-019-0195-8 (2019).","journal-title":"Mucosal. Immunol."},{"key":"71127_CR32","doi-asserted-by":"publisher","first-page":"251","DOI":"10.1136\/thx.2007.078006","volume":"63","author":"R Borie","year":"2008","unstructured":"Borie, R. et al. Activation of somatostatin receptors attenuates pulmonary fibrosis. Thorax 63, 251\u2013258. https:\/\/doi.org\/10.1136\/thx.2007.078006 (2008).","journal-title":"Thorax"},{"key":"71127_CR33","first-page":"1281","volume":"47","author":"R Lebtahi","year":"2006","unstructured":"Lebtahi, R. et al. Increased uptake of 111In-octreotide in idiopathic pulmonary fibrosis. J. Nuclear Med. Off. Publ. Society Nuclear Med. 47, 1281\u20131287 (2006).","journal-title":"J. Nuclear Med. Off. Publ. Society Nuclear Med."},{"issue":"Suppl 1","key":"71127_CR34","doi-asserted-by":"publisher","first-page":"S21","DOI":"10.1530\/eje.0.143s021","volume":"143","author":"EG Lichtenauer-Kaligis","year":"2000","unstructured":"Lichtenauer-Kaligis, E. G., van Hagen, P. M., Lamberts, S. W. & Hofland, L. J. Somatostatin receptor subtypes in human immune cells. Eur. J. Endocrinol. 143(Suppl 1), S21-25 (2000).","journal-title":"Eur. J. Endocrinol."},{"key":"71127_CR35","doi-asserted-by":"publisher","first-page":"1127","DOI":"10.1369\/jhc.2009.953919","volume":"57","author":"Z Varecza","year":"2009","unstructured":"Varecza, Z. et al. Expression of the somatostatin receptor subtype 4 in intact and inflamed pulmonary tissues. J. Histochem. Cytochem. Off. J. Histochem. Society 57, 1127\u20131137. https:\/\/doi.org\/10.1369\/jhc.2009.953919 (2009).","journal-title":"J. Histochem. Cytochem. Off. J. Histochem. Society"},{"key":"71127_CR36","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1186\/s12879-019-3705-0","volume":"19","author":"JS Molton","year":"2019","unstructured":"Molton, J. S. et al. Sub-clinical abnormalities detected by PET\/MRI in household tuberculosis contacts. BMC Infect. Dis. 19, 83. https:\/\/doi.org\/10.1186\/s12879-019-3705-0 (2019).","journal-title":"BMC Infect. Dis."},{"key":"71127_CR37","doi-asserted-by":"publisher","first-page":"253","DOI":"10.1089\/108497804323072039","volume":"19","author":"T Martins","year":"2004","unstructured":"Martins, T., Lino, J. S., Ramos, S. & Oliveira, L. 99mTc-depreotide scintigraphy in the evaluation of indeterminate pulmonary lesions: Clinical experience. Cancer Biother. Radiopharm. 19, 253\u2013259. https:\/\/doi.org\/10.1089\/108497804323072039 (2004).","journal-title":"Cancer Biother. Radiopharm."},{"key":"71127_CR38","doi-asserted-by":"publisher","first-page":"295","DOI":"10.1080\/02841850701793777","volume":"49","author":"R Axelsson","year":"2008","unstructured":"Axelsson, R., Herlin, G., Baath, M., Aspelin, P. & Kolbeck, K. G. Role of scintigraphy with technetium-99m depreotide in the diagnosis and management of patients with suspected lung cancer. Acta Radiol. (Stockholm, Sweden: 1987) 49, 295\u2013302. https:\/\/doi.org\/10.1080\/02841850701793777 (2008).","journal-title":"Acta Radiol. (Stockholm, Sweden: 1987)"},{"key":"71127_CR39","doi-asserted-by":"publisher","first-page":"343","DOI":"10.1097\/00003072-199905000-00010","volume":"24","author":"M Castellani","year":"1999","unstructured":"Castellani, M., Reschini, E., Gasparini, M. & Gerundini, P. Indium-111 pentetreotide lung uptake in infectious lung disease. Clin. Nucl. Med. 24, 343\u2013345. https:\/\/doi.org\/10.1097\/00003072-199905000-00010 (1999).","journal-title":"Clin. Nucl. Med."},{"key":"71127_CR40","doi-asserted-by":"publisher","first-page":"1927","DOI":"10.2967\/jnumed.109.066639","volume":"50","author":"I Kayani","year":"2009","unstructured":"Kayani, I. et al. A comparison of 68Ga-DOTATATE and 18F-FDG PET\/CT in pulmonary neuroendocrine tumors. J. Nuclear Med. Off. Publ. Society Nuclear Med. 50, 1927\u20131932. https:\/\/doi.org\/10.2967\/jnumed.109.066639 (2009).","journal-title":"J. Nuclear Med. Off. Publ. Society Nuclear Med."},{"key":"71127_CR41","doi-asserted-by":"publisher","first-page":"1417","DOI":"10.1152\/physrev.00032.2017","volume":"98","author":"LJ Quinton","year":"2018","unstructured":"Quinton, L. J., Walkey, A. J. & Mizgerd, J. P. Integrative physiology of pneumonia. Physiol. Rev. 98, 1417\u20131464. https:\/\/doi.org\/10.1152\/physrev.00032.2017 (2018).","journal-title":"Physiol. Rev."},{"key":"71127_CR42","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1016\/j.carres.2018.11.002","volume":"472","author":"S Pena-Zalbidea","year":"2019","unstructured":"Pena-Zalbidea, S. et al. Chemoenzymatic radiosynthesis of 2-deoxy-2-[(18)F]fluoro-d-trehalose ([(18)F]-2-FDTre): A PET radioprobe for in vivo tracing of trehalose metabolism. Carbohyd. Res. 472, 16\u201322. https:\/\/doi.org\/10.1016\/j.carres.2018.11.002 (2019).","journal-title":"Carbohyd. Res."},{"key":"71127_CR43","doi-asserted-by":"publisher","first-page":"639","DOI":"10.1097\/mnm.0000000000001017","volume":"40","author":"CH Tsao","year":"2019","unstructured":"Tsao, C. H. et al. Micro-PET imaging of [18F]fluoroacetate combined with [18F]FDG to differentiate chronic Mycobacterium tuberculosis infection from an acute bacterial infection in a mouse model: A preliminary study. Nucl. Med. Commun. 40, 639\u2013644. https:\/\/doi.org\/10.1097\/mnm.0000000000001017 (2019).","journal-title":"Nucl. Med. Commun."},{"key":"71127_CR44","doi-asserted-by":"publisher","first-page":"1116","DOI":"10.1016\/j.neuroimage.2006.01.015","volume":"31","author":"PA Yushkevich","year":"2006","unstructured":"Yushkevich, P. A. et al. User-guided 3D active contour segmentation of anatomical structures: Significantly improved efficiency and reliability. NeuroImage 31, 1116\u20131128. https:\/\/doi.org\/10.1016\/j.neuroimage.2006.01.015 (2006).","journal-title":"NeuroImage"},{"key":"71127_CR45","doi-asserted-by":"publisher","first-page":"196","DOI":"10.1109\/tmi.2009.2035616","volume":"29","author":"S Klein","year":"2010","unstructured":"Klein, S., Staring, M., Murphy, K., Viergever, M. A. & Pluim, J. P. elastix: a toolbox for intensity-based medical image registration. IEEE Trans. Med. Imaging 29, 196\u2013205. https:\/\/doi.org\/10.1109\/tmi.2009.2035616 (2010).","journal-title":"IEEE Trans. Med. Imaging"},{"key":"71127_CR46","doi-asserted-by":"publisher","first-page":"50","DOI":"10.3389\/fninf.2013.00050","volume":"7","author":"DP Shamonin","year":"2013","unstructured":"Shamonin, D. P. et al. Fast parallel image registration on CPU and GPU for diagnostic classification of Alzheimer\u2019s disease. Front. Neuroinform. 7, 50. https:\/\/doi.org\/10.3389\/fninf.2013.00050 (2013).","journal-title":"Front. Neuroinform."},{"key":"71127_CR47","doi-asserted-by":"publisher","first-page":"52","DOI":"10.1186\/s13550-016-0207-6","volume":"6","author":"LC Gormsen","year":"2016","unstructured":"Gormsen, L. C. et al. A dual tracer (68)Ga-DOTANOC PET\/CT and (18)F-FDG PET\/CT pilot study for detection of cardiac sarcoidosis. EJNMMI Res. 6, 52. https:\/\/doi.org\/10.1186\/s13550-016-0207-6 (2016).","journal-title":"EJNMMI Res."},{"key":"71127_CR48","doi-asserted-by":"publisher","first-page":"748","DOI":"10.1164\/rccm.201311-1976LE","volume":"189","author":"N Ghesani","year":"2014","unstructured":"Ghesani, N., Patrawalla, A., Lardizabal, A., Salgame, P. & Fennelly, K. P. Increased cellular activity in thoracic lymph nodes in early human latent tuberculosis infection. Am. J. Respir. Crit. Care Med. 189, 748\u2013750. https:\/\/doi.org\/10.1164\/rccm.201311-1976LE (2014).","journal-title":"Am. J. Respir. Crit. Care Med."}],"container-title":["Scientific Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41598-020-71127-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-020-71127-2","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-020-71127-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,12,6]],"date-time":"2022-12-06T18:19:53Z","timestamp":1670350793000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41598-020-71127-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,8,28]]},"references-count":48,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2020,12]]}},"alternative-id":["71127"],"URL":"https:\/\/doi.org\/10.1038\/s41598-020-71127-2","relation":{},"ISSN":["2045-2322"],"issn-type":[{"value":"2045-2322","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,8,28]]},"assertion":[{"value":"30 April 2020","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"5 August 2020","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 August 2020","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"14236"}}