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We aimed to validate the principle and investigate T1 mapping at rest and adenosine stress to differentiate ischemic and infarcted myocardium from controls. Patients with suspected coronary artery disease who underwent CMR were prospectively recruited. Native rest and adenosine stress T1 maps were obtained using standard modified Look-Locker Inversion-Recovery technique. Among 181 patients included, T1 values were measured from three groups. In the control group, 72 patients showed myocardium with a T1 profile of 1,039\u2009\u00b1\u200975\u00a0ms at rest and a significant increase during stress (4.79\u2009\u00b1\u20093.14%, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). While the ischemic (51 patients) and infarcted (58 patients) groups showed elevated resting T1 compared to controls (1,040\u2009\u00b1\u200990\u00a0ms for ischemic; 1,239\u2009\u00b1\u2009121\u00a0ms for infarcted, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001), neither of which presented significant T1 reactivity (1.38\u2009\u00b1\u20093.02% for ischemic; 1.55\u2009\u00b1\u20095.25% for infarcted). We concluded that adenosine stress and rest T1 mapping may be useful to differentiate normal, ischemic and infarcted myocardium.<\/jats:p>","DOI":"10.1038\/s41598-020-71722-3","type":"journal-article","created":{"date-parts":[[2020,9,7]],"date-time":"2020-09-07T10:02:52Z","timestamp":1599472972000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Clinical assessment of adenosine stress and rest cardiac magnetic resonance T1 mapping for detecting ischemic and infarcted myocardium"],"prefix":"10.1038","volume":"10","author":[{"given":"Sirilak","family":"Yimcharoen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuo","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yodying","family":"Kaolawanich","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Prajak","family":"Tanapibunpon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rungroj","family":"Krittayaphong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2020,9,7]]},"reference":[{"key":"71722_CR1","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1016\/S0140-6736(14)61682-2","volume":"385","author":"GBD Mortality","year":"2015","unstructured":"Mortality, G. 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