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Yet most of the existing literature is on inorganic substrates and the underlying effects of the PDA layer coatings on the nucleation and mineralization process and the mineral-substrate interface have not been clearly identified. Here we aimed to investigate the effects of the PDA layer on the nucleation and growth and interfacial morphology of calcium phosphate mineral layer (CaP) from 10\u00d7 simulated body fluid (10\u00d7 SBF) on polymeric substrates. It is found that the nucleation of CaP on PDA-coated surface favors a mixed \u201cislanding\u201d and planar growth mode (Stranski\u2013Krastanov) while the \u201cislanding\u201d mode (Volmer\u2013Weber) was observed on the surface without PDA. This different early nucleation stage of mineralization was found to correlate with a more \u201cbonded\u201d interface between the mineral layer and the PDA-coated substrates, a slight increase in the interfacial strength and a different delamination mode. This study therefore provided new insights on how polydopamine priming layer influenced the mineralization process and the interface between the mineral layer and the substrate.<\/jats:p>","DOI":"10.1038\/s41598-020-71900-3","type":"journal-article","created":{"date-parts":[[2020,9,11]],"date-time":"2020-09-11T10:09:21Z","timestamp":1599818961000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":37,"title":["Effects of polydopamine coatings on nucleation modes of surface mineralization from simulated body fluid"],"prefix":"10.1038","volume":"10","author":[{"given":"Giovannimaria","family":"Murari","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathalie","family":"Bock","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huan","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teresa","family":"Liew","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kate","family":"Fox","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Phong A.","family":"Tran","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2020,9,11]]},"reference":[{"issue":"19","key":"71900_CR1","doi-asserted-by":"publisher","first-page":"1601192","DOI":"10.1002\/admi.201601192","volume":"4","author":"TG Barclay","year":"2017","unstructured":"Barclay, T. 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